HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI
The aim of the present work was the study of children's health in the Northern areas of the Zabaykalsky Krai. The study was conducted on the territory of Tungokochenskiy, Tungiro-Olekmenskiy and Kalarskiy areas. A random sample of 1339 children and adolescents of indigenous population and newco...
Main Authors: | , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | Russian |
Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2013
|
Subjects: | |
Online Access: | https://doaj.org/article/556a323ea0384d6a838e3e98f68f9085 |
id |
ftdoajarticles:oai:doaj.org/article:556a323ea0384d6a838e3e98f68f9085 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:556a323ea0384d6a838e3e98f68f9085 2024-09-09T19:39:33+00:00 HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI G. I. Bisharova N. I. Zubina E. E. Gergesova O. E. Bartuhina T. A. Chuprova 2013-07-01T00:00:00Z https://doaj.org/article/556a323ea0384d6a838e3e98f68f9085 RU rus Scientific Сentre for Family Health and Human Reproduction Problems https://www.actabiomedica.ru/jour/article/view/1610 https://doaj.org/toc/2541-9420 https://doaj.org/toc/2587-9596 2541-9420 2587-9596 https://doaj.org/article/556a323ea0384d6a838e3e98f68f9085 Acta Biomedica Scientifica, Vol 0, Iss 4, Pp 93-98 (2013) native and alien population evenks gene polymorphism Science Q article 2013 ftdoajarticles 2024-08-05T17:49:16Z The aim of the present work was the study of children's health in the Northern areas of the Zabaykalsky Krai. The study was conducted on the territory of Tungokochenskiy, Tungiro-Olekmenskiy and Kalarskiy areas. A random sample of 1339 children and adolescents of indigenous population and newcomers to the Northern regions was examined, including 254 Evenks. Conducted examinations of employees of Regional Children Consultation and Diagnostic Center; functional diagnostics, ultrasound diagnostics; laboratory diagnostics: determination of urinary iodine ионоселективным method, ELISA screening helminthes, evaluation of the humoral immunity, evaluation of hormonal status, study GSTP1 polymorphism of genes (Ile105Val), TNF-alpha (G308A), IL-10 (G1082A) and IL-4 (C589T) using PCR-Rv children of indigenous peoples of the Northern regions of the Zabaykalsky Krai (Evenk). On the basis of the analysis of the results of field work the following results were received: pathological affection of the child population was 2542 %, Evenk children 4791 %; the main ranking place among somatic pathology among children, the alien population of the Northern regions, corresponds to those of the children of Slavic group. Besides, the fact that the rate of pathological prevalence among Evenk children in 2 times higher, than among children of the alien population, creates quite a different picture of the distribution of nosological forms. We identified the features of the distribution of polymorphic variants of genes GSTP1 (Ile105Val), TNF-alpha (G308A), IL-10 (G1082A) and IL-4 (C589T) Evenks, which, in our opinion, warrant, together with factors of the external environment, a pattern of morbidity among children of the indigenous residents of Northern Transbaikalia. The data we have on overall morbidity and pathological prevalence of children in studied areas of Transbaikalia correspond with the results of molecular-genetic research. Article in Journal/Newspaper Evenk Evenks Directory of Open Access Journals: DOAJ Articles |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
native and alien population evenks gene polymorphism Science Q |
spellingShingle |
native and alien population evenks gene polymorphism Science Q G. I. Bisharova N. I. Zubina E. E. Gergesova O. E. Bartuhina T. A. Chuprova HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI |
topic_facet |
native and alien population evenks gene polymorphism Science Q |
description |
The aim of the present work was the study of children's health in the Northern areas of the Zabaykalsky Krai. The study was conducted on the territory of Tungokochenskiy, Tungiro-Olekmenskiy and Kalarskiy areas. A random sample of 1339 children and adolescents of indigenous population and newcomers to the Northern regions was examined, including 254 Evenks. Conducted examinations of employees of Regional Children Consultation and Diagnostic Center; functional diagnostics, ultrasound diagnostics; laboratory diagnostics: determination of urinary iodine ионоселективным method, ELISA screening helminthes, evaluation of the humoral immunity, evaluation of hormonal status, study GSTP1 polymorphism of genes (Ile105Val), TNF-alpha (G308A), IL-10 (G1082A) and IL-4 (C589T) using PCR-Rv children of indigenous peoples of the Northern regions of the Zabaykalsky Krai (Evenk). On the basis of the analysis of the results of field work the following results were received: pathological affection of the child population was 2542 %, Evenk children 4791 %; the main ranking place among somatic pathology among children, the alien population of the Northern regions, corresponds to those of the children of Slavic group. Besides, the fact that the rate of pathological prevalence among Evenk children in 2 times higher, than among children of the alien population, creates quite a different picture of the distribution of nosological forms. We identified the features of the distribution of polymorphic variants of genes GSTP1 (Ile105Val), TNF-alpha (G308A), IL-10 (G1082A) and IL-4 (C589T) Evenks, which, in our opinion, warrant, together with factors of the external environment, a pattern of morbidity among children of the indigenous residents of Northern Transbaikalia. The data we have on overall morbidity and pathological prevalence of children in studied areas of Transbaikalia correspond with the results of molecular-genetic research. |
format |
Article in Journal/Newspaper |
author |
G. I. Bisharova N. I. Zubina E. E. Gergesova O. E. Bartuhina T. A. Chuprova |
author_facet |
G. I. Bisharova N. I. Zubina E. E. Gergesova O. E. Bartuhina T. A. Chuprova |
author_sort |
G. I. Bisharova |
title |
HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI |
title_short |
HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI |
title_full |
HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI |
title_fullStr |
HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI |
title_full_unstemmed |
HEALTH STATUS AND SOME GENES POLYMORPHISM IN CHILDREN OF NORTHERN AREAS OF THE ZABAYKALSKY KRAI |
title_sort |
health status and some genes polymorphism in children of northern areas of the zabaykalsky krai |
publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
publishDate |
2013 |
url |
https://doaj.org/article/556a323ea0384d6a838e3e98f68f9085 |
genre |
Evenk Evenks |
genre_facet |
Evenk Evenks |
op_source |
Acta Biomedica Scientifica, Vol 0, Iss 4, Pp 93-98 (2013) |
op_relation |
https://www.actabiomedica.ru/jour/article/view/1610 https://doaj.org/toc/2541-9420 https://doaj.org/toc/2587-9596 2541-9420 2587-9596 https://doaj.org/article/556a323ea0384d6a838e3e98f68f9085 |
_version_ |
1809908669164290048 |