Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia
Hepatobiliary alterations found in an autopsy case of massive Biliary Ascariasis, are reported on histological grounds. Severe cholangitis was the main finding, but other changes were also detected, such as pyloric and intestinal metaplasia, hyperplasia of the epithelial lining, with intraductal pap...
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Universidade de São Paulo (USP)
1990
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ftdoajarticles:oai:doaj.org/article:5550528b918d422f8ed40739e55c38cd 2024-09-09T19:27:30+00:00 Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia Luiz Carlos da Costa Gayotto Regina Maria Leitão Muszkat Irene Vieira Souza 1990-04-01T00:00:00Z https://doi.org/10.1590/S0036-46651990000200005 https://doaj.org/article/5550528b918d422f8ed40739e55c38cd EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651990000200005 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651990000200005 0036-4665 1678-9946 https://doaj.org/article/5550528b918d422f8ed40739e55c38cd Revista do Instituto de Medicina Tropical de São Paulo, Vol 32, Iss 2, Pp 91-95 (1990) Ascariasis Recurrent Pyogenic Cholangitis Bile Ducts Helminthic Infection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1990 ftdoajarticles https://doi.org/10.1590/S0036-46651990000200005 2024-08-05T17:49:30Z Hepatobiliary alterations found in an autopsy case of massive Biliary Ascariasis, are reported on histological grounds. Severe cholangitis was the main finding, but other changes were also detected, such as pyloric and intestinal metaplasia, hyperplasia of the epithelial lining, with intraductal papillomas and adenomatous proliferation. Remnants of the worm were observed tightly adhered to the epithelium, forming microscopic intrahepatic calculi. Mucopolysaccharides, especially acid, showed to be strongly positive on the luminal border, and in proliferated glands around the ducts. The authors discuss the similarity between such findings and Oriental Cholangiohepatitis, and suggest that inflammation and the presence of the parasitic remnants are responsible for the hyperplastic and metaplastic changes, similarly with what occurs in chlonorchiasis, fascioliasis and schistosomiasis. Os autores apresentam os aspectos histopatológicos encontrados no fígado de um caso de autópsia de Ascaridíase Biliar maciça. A intensa colangite foi o aspecto predominante, mas outras lesões também foram encontradas, tais como metaplasia pilórica e intestinal, hiperplasia epitelial com papilomas intraductais, e por vezes padrão adenomatoso. Restos do helminto foram encontrados fortemente aderidos ao epitélio, sendo intensa a positividade de mucopolissacárides, principalmente ácidos, na borda luminal do epitélio ductal e em glândulas proliferadas ao redor dos ductos. Os autores discutem a semelhança da Ascaridíase Biliar com a Colangio Hepatite Oriental, e sugerem que o processo inflamatório e a presença de restos do verme são responsáveis pelas alterações hiperplásicas e metaplásicas, analogamente ao que ocorre na clonorquíase, fasciolíase e esquistossomose. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 32 2 91 95 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Ascariasis Recurrent Pyogenic Cholangitis Bile Ducts Helminthic Infection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Ascariasis Recurrent Pyogenic Cholangitis Bile Ducts Helminthic Infection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Luiz Carlos da Costa Gayotto Regina Maria Leitão Muszkat Irene Vieira Souza Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
topic_facet |
Ascariasis Recurrent Pyogenic Cholangitis Bile Ducts Helminthic Infection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Hepatobiliary alterations found in an autopsy case of massive Biliary Ascariasis, are reported on histological grounds. Severe cholangitis was the main finding, but other changes were also detected, such as pyloric and intestinal metaplasia, hyperplasia of the epithelial lining, with intraductal papillomas and adenomatous proliferation. Remnants of the worm were observed tightly adhered to the epithelium, forming microscopic intrahepatic calculi. Mucopolysaccharides, especially acid, showed to be strongly positive on the luminal border, and in proliferated glands around the ducts. The authors discuss the similarity between such findings and Oriental Cholangiohepatitis, and suggest that inflammation and the presence of the parasitic remnants are responsible for the hyperplastic and metaplastic changes, similarly with what occurs in chlonorchiasis, fascioliasis and schistosomiasis. Os autores apresentam os aspectos histopatológicos encontrados no fígado de um caso de autópsia de Ascaridíase Biliar maciça. A intensa colangite foi o aspecto predominante, mas outras lesões também foram encontradas, tais como metaplasia pilórica e intestinal, hiperplasia epitelial com papilomas intraductais, e por vezes padrão adenomatoso. Restos do helminto foram encontrados fortemente aderidos ao epitélio, sendo intensa a positividade de mucopolissacárides, principalmente ácidos, na borda luminal do epitélio ductal e em glândulas proliferadas ao redor dos ductos. Os autores discutem a semelhança da Ascaridíase Biliar com a Colangio Hepatite Oriental, e sugerem que o processo inflamatório e a presença de restos do verme são responsáveis pelas alterações hiperplásicas e metaplásicas, analogamente ao que ocorre na clonorquíase, fasciolíase e esquistossomose. |
format |
Article in Journal/Newspaper |
author |
Luiz Carlos da Costa Gayotto Regina Maria Leitão Muszkat Irene Vieira Souza |
author_facet |
Luiz Carlos da Costa Gayotto Regina Maria Leitão Muszkat Irene Vieira Souza |
author_sort |
Luiz Carlos da Costa Gayotto |
title |
Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
title_short |
Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
title_full |
Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
title_fullStr |
Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
title_full_unstemmed |
Hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case Lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
title_sort |
hepatobiliary alterations in massive biliary ascariasis: histopathological aspects of an autopsy case lesões hepatobiliares em ascaridíase biliar maciça: aspectos histopatológicos em um caso de autópsia |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1990 |
url |
https://doi.org/10.1590/S0036-46651990000200005 https://doaj.org/article/5550528b918d422f8ed40739e55c38cd |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 32, Iss 2, Pp 91-95 (1990) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651990000200005 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651990000200005 0036-4665 1678-9946 https://doaj.org/article/5550528b918d422f8ed40739e55c38cd |
op_doi |
https://doi.org/10.1590/S0036-46651990000200005 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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32 |
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2 |
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91 |
op_container_end_page |
95 |
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