Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India
Abstract Background Malaria is a major public health problem in India and accounts for about 88% of malaria burden in South-East Asia. India alone accounted for 2% of total malaria cases globally. Anti-malarial drug resistance is one of the major problems for malaria control and elimination programm...
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ftdoajarticles:oai:doaj.org/article:553f219d277645bfb5ca7a7619651836 2023-05-15T15:16:08+02:00 Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India Sri Krishna Sweta Mishra Prakash Tiwari Anup K. Vishwakarma Sushrikanta Khandai Suyesh Shrivastava Anil K. Verma Shashikant Tiwari Hari Barman Surendra Jhariya Pradeep Tiwari Anup S. Tidgam Brij M. Varun Sunil Singh Naresh Yerane Chintaman R. Tembhurne Prem L. Mandavi Shyam S. Tekam Manas Malik Kali P. Behera Himanshu Jayswar Khemraj Sonwani Mukund S. Diggikar Madan M. Pradhan Sher S. Khasotiya Avdhesh Kumar Neeraj Dhingra Maria Dorina G. Bustos Eva-Maria Christophel Pascal Ringwald Roop Kumari Man M. Shukla Neeru Singh Aparup Das Praveen K. Bharti 2021-05-01T00:00:00Z https://doi.org/10.1186/s12936-021-03762-7 https://doaj.org/article/553f219d277645bfb5ca7a7619651836 EN eng BMC https://doi.org/10.1186/s12936-021-03762-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03762-7 1475-2875 https://doaj.org/article/553f219d277645bfb5ca7a7619651836 Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021) Therapeutic efficacy Artemether-lumefantrine Plasmodium falciparum Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03762-7 2022-12-31T13:10:43Z Abstract Background Malaria is a major public health problem in India and accounts for about 88% of malaria burden in South-East Asia. India alone accounted for 2% of total malaria cases globally. Anti-malarial drug resistance is one of the major problems for malaria control and elimination programme. Artemether-lumefantrine (AL) is the first-line treatment of uncomplicated Plasmodium falciparum in north eastern states of India since 2013 after confirming the resistance against sulfadoxine-pyrimethamine. In the present study, therapeutic efficacy of artemether-lumefantrine and k13 polymorphism was assessed in uncomplicated P. falciparum malaria. Methods This study was conducted at four community health centres located in Koraput district of Odisha, Bastar district of Chhattisgarh, Balaghat district of Madhya Pradesh and Gondia district of Maharashtra state. Patients with uncomplicated P. falciparum malaria were administered with fixed dose combination (6 doses) of artemether-lumefantrine for 3 days and clinical and parasitological response was recorded up to 28 days as per World Health Organization protocol. Nucleotide sequencing of msp1 and msp2 gene was performed to differentiate between recrudescence and reinfection. Amplification and sequencing of k13 propeller gene region covering codon 450–680 was also carried out to identify the polymorphism. Results A total 376 malaria patients who fulfilled the enrolment criteria as well as consented for the study were enrolled. Total 356 patients were followed up successfully up to 28 days. Overall, the adequate clinical and parasitological response was 98.9% and 99.4% with and without PCR correction respectively. No case of early treatment failure was observed. However, four cases (1.1%) of late parasitological failure were found from the Bastar district of Chhattisgarh. Genotyping of msp1 and msp2 confirmed 2 cases each of recrudescence and reinfection, respectively. Mutation analysis of k13 propeller gene showed one non-synonymous mutation Q613H in one isolate from ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
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Therapeutic efficacy Artemether-lumefantrine Plasmodium falciparum Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Therapeutic efficacy Artemether-lumefantrine Plasmodium falciparum Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Sri Krishna Sweta Mishra Prakash Tiwari Anup K. Vishwakarma Sushrikanta Khandai Suyesh Shrivastava Anil K. Verma Shashikant Tiwari Hari Barman Surendra Jhariya Pradeep Tiwari Anup S. Tidgam Brij M. Varun Sunil Singh Naresh Yerane Chintaman R. Tembhurne Prem L. Mandavi Shyam S. Tekam Manas Malik Kali P. Behera Himanshu Jayswar Khemraj Sonwani Mukund S. Diggikar Madan M. Pradhan Sher S. Khasotiya Avdhesh Kumar Neeraj Dhingra Maria Dorina G. Bustos Eva-Maria Christophel Pascal Ringwald Roop Kumari Man M. Shukla Neeru Singh Aparup Das Praveen K. Bharti Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India |
topic_facet |
Therapeutic efficacy Artemether-lumefantrine Plasmodium falciparum Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is a major public health problem in India and accounts for about 88% of malaria burden in South-East Asia. India alone accounted for 2% of total malaria cases globally. Anti-malarial drug resistance is one of the major problems for malaria control and elimination programme. Artemether-lumefantrine (AL) is the first-line treatment of uncomplicated Plasmodium falciparum in north eastern states of India since 2013 after confirming the resistance against sulfadoxine-pyrimethamine. In the present study, therapeutic efficacy of artemether-lumefantrine and k13 polymorphism was assessed in uncomplicated P. falciparum malaria. Methods This study was conducted at four community health centres located in Koraput district of Odisha, Bastar district of Chhattisgarh, Balaghat district of Madhya Pradesh and Gondia district of Maharashtra state. Patients with uncomplicated P. falciparum malaria were administered with fixed dose combination (6 doses) of artemether-lumefantrine for 3 days and clinical and parasitological response was recorded up to 28 days as per World Health Organization protocol. Nucleotide sequencing of msp1 and msp2 gene was performed to differentiate between recrudescence and reinfection. Amplification and sequencing of k13 propeller gene region covering codon 450–680 was also carried out to identify the polymorphism. Results A total 376 malaria patients who fulfilled the enrolment criteria as well as consented for the study were enrolled. Total 356 patients were followed up successfully up to 28 days. Overall, the adequate clinical and parasitological response was 98.9% and 99.4% with and without PCR correction respectively. No case of early treatment failure was observed. However, four cases (1.1%) of late parasitological failure were found from the Bastar district of Chhattisgarh. Genotyping of msp1 and msp2 confirmed 2 cases each of recrudescence and reinfection, respectively. Mutation analysis of k13 propeller gene showed one non-synonymous mutation Q613H in one isolate from ... |
format |
Article in Journal/Newspaper |
author |
Sri Krishna Sweta Mishra Prakash Tiwari Anup K. Vishwakarma Sushrikanta Khandai Suyesh Shrivastava Anil K. Verma Shashikant Tiwari Hari Barman Surendra Jhariya Pradeep Tiwari Anup S. Tidgam Brij M. Varun Sunil Singh Naresh Yerane Chintaman R. Tembhurne Prem L. Mandavi Shyam S. Tekam Manas Malik Kali P. Behera Himanshu Jayswar Khemraj Sonwani Mukund S. Diggikar Madan M. Pradhan Sher S. Khasotiya Avdhesh Kumar Neeraj Dhingra Maria Dorina G. Bustos Eva-Maria Christophel Pascal Ringwald Roop Kumari Man M. Shukla Neeru Singh Aparup Das Praveen K. Bharti |
author_facet |
Sri Krishna Sweta Mishra Prakash Tiwari Anup K. Vishwakarma Sushrikanta Khandai Suyesh Shrivastava Anil K. Verma Shashikant Tiwari Hari Barman Surendra Jhariya Pradeep Tiwari Anup S. Tidgam Brij M. Varun Sunil Singh Naresh Yerane Chintaman R. Tembhurne Prem L. Mandavi Shyam S. Tekam Manas Malik Kali P. Behera Himanshu Jayswar Khemraj Sonwani Mukund S. Diggikar Madan M. Pradhan Sher S. Khasotiya Avdhesh Kumar Neeraj Dhingra Maria Dorina G. Bustos Eva-Maria Christophel Pascal Ringwald Roop Kumari Man M. Shukla Neeru Singh Aparup Das Praveen K. Bharti |
author_sort |
Sri Krishna |
title |
Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India |
title_short |
Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India |
title_full |
Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India |
title_fullStr |
Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India |
title_full_unstemmed |
Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India |
title_sort |
therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated plasmodium falciparum malaria in four malaria endemic states of india |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03762-7 https://doaj.org/article/553f219d277645bfb5ca7a7619651836 |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03762-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03762-7 1475-2875 https://doaj.org/article/553f219d277645bfb5ca7a7619651836 |
op_doi |
https://doi.org/10.1186/s12936-021-03762-7 |
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Malaria Journal |
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