Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial.
Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health efforts have the potential to significantly improve disease ou...
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ftdoajarticles:oai:doaj.org/article:5506cc0bc013428bbe5d15454b248cec 2023-05-15T15:11:49+02:00 Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. Sandor Klis Adelita Ranchor Richard O Phillips Kabiru M Abass Wilson Tuah Susanne Loth Kristien Velding Tjip S van der Werf Ymkje Stienstra 2014-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002964 https://doaj.org/article/5506cc0bc013428bbe5d15454b248cec EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4091870?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002964 https://doaj.org/article/5506cc0bc013428bbe5d15454b248cec PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2964 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002964 2022-12-31T01:33:07Z Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health efforts have the potential to significantly improve disease outcome.To study the Quality of Life (QoL) of former Buruli Ulcer patients who, in the context of a randomized controlled trial, reported early with small lesions (cross-sectional diameter <10 cm), and received a full course of antibiotic treatment.127 Participants of the BURULICO drug trial in Ghana were revisited. All former patients aged 16 or older completed the Dermatology Life Quality Index (DLQI) and the abbreviated World Health Organization Quality of Life scale (WHOQOL-BREF). The WHOQOL-BREF was also administered to 82 matched healthy controls. Those younger than 16 completed the Childrens' Dermatology Life Quality Index (CDLQI) only.The median (Inter Quartile Range) score on the DLQI was 0 (0-4), indicating good QoL. 85% of former patients indicated no effect, or only a small effect of the disease on their current life. Former patients also indicated good QoL on the physical and psychological domains of the WHOQOL-BREF, and scored significantly higher than healthy controls on these domains. There was a weak correlation between the DLQI and scar size (ρ = 0.32; p<0.001).BU patients who report early with small lesions and receive 8 weeks of antimicrobial therapy have a good QoL at long-term follow-up. These findings contrast with the debilitating sequelae often reported in BU, and highlight the importance of early case detection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 7 e2964 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sandor Klis Adelita Ranchor Richard O Phillips Kabiru M Abass Wilson Tuah Susanne Loth Kristien Velding Tjip S van der Werf Ymkje Stienstra Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health efforts have the potential to significantly improve disease outcome.To study the Quality of Life (QoL) of former Buruli Ulcer patients who, in the context of a randomized controlled trial, reported early with small lesions (cross-sectional diameter <10 cm), and received a full course of antibiotic treatment.127 Participants of the BURULICO drug trial in Ghana were revisited. All former patients aged 16 or older completed the Dermatology Life Quality Index (DLQI) and the abbreviated World Health Organization Quality of Life scale (WHOQOL-BREF). The WHOQOL-BREF was also administered to 82 matched healthy controls. Those younger than 16 completed the Childrens' Dermatology Life Quality Index (CDLQI) only.The median (Inter Quartile Range) score on the DLQI was 0 (0-4), indicating good QoL. 85% of former patients indicated no effect, or only a small effect of the disease on their current life. Former patients also indicated good QoL on the physical and psychological domains of the WHOQOL-BREF, and scored significantly higher than healthy controls on these domains. There was a weak correlation between the DLQI and scar size (ρ = 0.32; p<0.001).BU patients who report early with small lesions and receive 8 weeks of antimicrobial therapy have a good QoL at long-term follow-up. These findings contrast with the debilitating sequelae often reported in BU, and highlight the importance of early case detection. |
format |
Article in Journal/Newspaper |
author |
Sandor Klis Adelita Ranchor Richard O Phillips Kabiru M Abass Wilson Tuah Susanne Loth Kristien Velding Tjip S van der Werf Ymkje Stienstra |
author_facet |
Sandor Klis Adelita Ranchor Richard O Phillips Kabiru M Abass Wilson Tuah Susanne Loth Kristien Velding Tjip S van der Werf Ymkje Stienstra |
author_sort |
Sandor Klis |
title |
Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. |
title_short |
Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. |
title_full |
Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. |
title_fullStr |
Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. |
title_full_unstemmed |
Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. |
title_sort |
good quality of life in former buruli ulcer patients with small lesions: long-term follow-up of the burulico trial. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002964 https://doaj.org/article/5506cc0bc013428bbe5d15454b248cec |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2964 (2014) |
op_relation |
http://europepmc.org/articles/PMC4091870?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002964 https://doaj.org/article/5506cc0bc013428bbe5d15454b248cec |
op_doi |
https://doi.org/10.1371/journal.pntd.0002964 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
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7 |
container_start_page |
e2964 |
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