Health-related quality of life in patients with hepatitis C virus infection in Brazil
OBJECTIVE: To quantify the health-related quality of life (HRQoL) burden of hepatitis C virus (HCV) infection among a broad sample of adults in Brazil, particularly among those 40 years of age and older. METHODS: This was a retrospective observational study of data from the 2011 Brazil National Heal...
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ftdoajarticles:oai:doaj.org/article:54f5caf2323041c48c76bc6362ffa516 2023-05-15T15:15:22+02:00 Health-related quality of life in patients with hepatitis C virus infection in Brazil Antoine C. El Khoury Jeffrey Vietri Girish Prajapati 2014-03-01T00:00:00Z https://doaj.org/article/54f5caf2323041c48c76bc6362ffa516 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892014000300006&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/54f5caf2323041c48c76bc6362ffa516 Revista Panamericana de Salud Pública, Vol 35, Iss 3, Pp 200-206 (2014) Hepatitis C calidad de vida Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles 2022-12-31T11:39:02Z OBJECTIVE: To quantify the health-related quality of life (HRQoL) burden of hepatitis C virus (HCV) infection among a broad sample of adults in Brazil, particularly among those 40 years of age and older. METHODS: This was a retrospective observational study of data from the 2011 Brazil National Health and Wellness Survey, a large (n = 12 000) cross-sectional survey that includes information on medical conditions and health outcomes, including the Medical Outcomes Study Short-form 12 health questionnaire, version 2 (SF-12v2). Respondents who reported a physician diagnosis of HCV infection were compared with those who reported never experiencing HCV on the Mental (MCS) and Physical (PCS) Component Summary scores and SF-6D health utility scores. Unadjusted comparisons were conducted with chi-square tests for categorical variables and t-tests for continuous variables. Regression was used to adjust outcomes for potential confounds. Subgroup analyses were conducted on those 40 years of age and older. RESULTS: Unadjusted comparisons between respondents infected with HCV (n = 100) and controls (n = 11 694) revealed similar MCS and PCS scores, but HCV patients had lower SF-6D utility scores (0.70 vs. 0.73, P < 0.05). Regressions adjusting for demographic and health characteristics provided similar results to unadjusted comparisons. Subgroup analyses of respondents 40 years of age and older revealed decrements in both MCS (45.95 vs. 49.72, P < 0.05) and SF-6D (0.71 vs. 0.76, P < 0.05). PCS scores were comparable in HCV patients and controls. CONCLUSIONS: HCV infection in Brazil causes significant HRQoL burden, especially among the older population. Prevention measures to curtail the spread of the virus in Brazil should provide societal benefits in terms of quality of life, in addition to preventing morbidity and mortality from chronic infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English Spanish Portuguese |
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Hepatitis C calidad de vida Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Hepatitis C calidad de vida Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Antoine C. El Khoury Jeffrey Vietri Girish Prajapati Health-related quality of life in patients with hepatitis C virus infection in Brazil |
topic_facet |
Hepatitis C calidad de vida Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To quantify the health-related quality of life (HRQoL) burden of hepatitis C virus (HCV) infection among a broad sample of adults in Brazil, particularly among those 40 years of age and older. METHODS: This was a retrospective observational study of data from the 2011 Brazil National Health and Wellness Survey, a large (n = 12 000) cross-sectional survey that includes information on medical conditions and health outcomes, including the Medical Outcomes Study Short-form 12 health questionnaire, version 2 (SF-12v2). Respondents who reported a physician diagnosis of HCV infection were compared with those who reported never experiencing HCV on the Mental (MCS) and Physical (PCS) Component Summary scores and SF-6D health utility scores. Unadjusted comparisons were conducted with chi-square tests for categorical variables and t-tests for continuous variables. Regression was used to adjust outcomes for potential confounds. Subgroup analyses were conducted on those 40 years of age and older. RESULTS: Unadjusted comparisons between respondents infected with HCV (n = 100) and controls (n = 11 694) revealed similar MCS and PCS scores, but HCV patients had lower SF-6D utility scores (0.70 vs. 0.73, P < 0.05). Regressions adjusting for demographic and health characteristics provided similar results to unadjusted comparisons. Subgroup analyses of respondents 40 years of age and older revealed decrements in both MCS (45.95 vs. 49.72, P < 0.05) and SF-6D (0.71 vs. 0.76, P < 0.05). PCS scores were comparable in HCV patients and controls. CONCLUSIONS: HCV infection in Brazil causes significant HRQoL burden, especially among the older population. Prevention measures to curtail the spread of the virus in Brazil should provide societal benefits in terms of quality of life, in addition to preventing morbidity and mortality from chronic infection. |
format |
Article in Journal/Newspaper |
author |
Antoine C. El Khoury Jeffrey Vietri Girish Prajapati |
author_facet |
Antoine C. El Khoury Jeffrey Vietri Girish Prajapati |
author_sort |
Antoine C. El Khoury |
title |
Health-related quality of life in patients with hepatitis C virus infection in Brazil |
title_short |
Health-related quality of life in patients with hepatitis C virus infection in Brazil |
title_full |
Health-related quality of life in patients with hepatitis C virus infection in Brazil |
title_fullStr |
Health-related quality of life in patients with hepatitis C virus infection in Brazil |
title_full_unstemmed |
Health-related quality of life in patients with hepatitis C virus infection in Brazil |
title_sort |
health-related quality of life in patients with hepatitis c virus infection in brazil |
publisher |
Pan American Health Organization |
publishDate |
2014 |
url |
https://doaj.org/article/54f5caf2323041c48c76bc6362ffa516 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 35, Iss 3, Pp 200-206 (2014) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892014000300006&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/54f5caf2323041c48c76bc6362ffa516 |
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1766345735411859456 |