ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM
SUMMARY Regarding public health in Brazil, a new scenario emerged with the establishment of universal rotavirus (RV) vaccination programs. Herein, the data from the five years of surveillance (2007-2012) of G- and P-type RV strains isolated from individuals with acute gastroenteritis in Brazil are r...
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ftdoajarticles:oai:doaj.org/article:54d08122872e43ecbedb8d555b08ecc3 2024-09-09T19:26:46+00:00 ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM Adriana LUCHS Audrey CILLI Simone Guadagnucci MORILLO Rita de Cássia Compagnoli CARMONA Maria do Carmo Sampaio Tavares TIMENETSKY 2015-08-01T00:00:00Z https://doi.org/10.1590/S0036-46652015000400006 https://doaj.org/article/54d08122872e43ecbedb8d555b08ecc3 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000400305&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652015000400006 https://doaj.org/article/54d08122872e43ecbedb8d555b08ecc3 Revista do Instituto de Medicina Tropical de São Paulo, Vol 57, Iss 4, Pp 305-313 (2015) Rotavirus Genotypes Surveillance Vaccine Gastroenteritis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2015 ftdoajarticles https://doi.org/10.1590/S0036-46652015000400006 2024-08-05T17:49:31Z SUMMARY Regarding public health in Brazil, a new scenario emerged with the establishment of universal rotavirus (RV) vaccination programs. Herein, the data from the five years of surveillance (2007-2012) of G- and P-type RV strains isolated from individuals with acute gastroenteritis in Brazil are reported. A total of 6,196 fecal specimens were investigated by ELISA and RT-PCR. RVs were detected in 19.1% (1,181/6,196). The peak of RV incidence moved from June-August to September. RV was detected less frequently (19.5%) among children ≤ 5 years than in older children and adolescents (6-18 years) (40.6%). Genotype distribution showed a different profile for each year: G2P[4] strains were most prevalent during 2007-2010, G9P[8] in 2011, and G12P[8] in 2012. Mixed infections (G1+G2P[4], G2+G3P[4]+P[8], G2+G12P[8]), unusual combinations (G1P[4], G2P[6]), and rare strains (G3P[3]) were also identified throughout the study period. Widespread vaccination may alter the RV seasonal pattern. The finding of RV disease affecting older children and adolescents after vaccine implementation has been reported worldwide. G2P[4] emergence most likely follows a global trend seemingly unrelated to vaccination, and G12, apparently, is emerging in the Brazilian population. The rapidly changing RV genotype patterns detected during this study illustrate a dynamic population of co-circulating wildtype RVs in Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 57 4 305 313 |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Rotavirus Genotypes Surveillance Vaccine Gastroenteritis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Rotavirus Genotypes Surveillance Vaccine Gastroenteritis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Adriana LUCHS Audrey CILLI Simone Guadagnucci MORILLO Rita de Cássia Compagnoli CARMONA Maria do Carmo Sampaio Tavares TIMENETSKY ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM |
topic_facet |
Rotavirus Genotypes Surveillance Vaccine Gastroenteritis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
SUMMARY Regarding public health in Brazil, a new scenario emerged with the establishment of universal rotavirus (RV) vaccination programs. Herein, the data from the five years of surveillance (2007-2012) of G- and P-type RV strains isolated from individuals with acute gastroenteritis in Brazil are reported. A total of 6,196 fecal specimens were investigated by ELISA and RT-PCR. RVs were detected in 19.1% (1,181/6,196). The peak of RV incidence moved from June-August to September. RV was detected less frequently (19.5%) among children ≤ 5 years than in older children and adolescents (6-18 years) (40.6%). Genotype distribution showed a different profile for each year: G2P[4] strains were most prevalent during 2007-2010, G9P[8] in 2011, and G12P[8] in 2012. Mixed infections (G1+G2P[4], G2+G3P[4]+P[8], G2+G12P[8]), unusual combinations (G1P[4], G2P[6]), and rare strains (G3P[3]) were also identified throughout the study period. Widespread vaccination may alter the RV seasonal pattern. The finding of RV disease affecting older children and adolescents after vaccine implementation has been reported worldwide. G2P[4] emergence most likely follows a global trend seemingly unrelated to vaccination, and G12, apparently, is emerging in the Brazilian population. The rapidly changing RV genotype patterns detected during this study illustrate a dynamic population of co-circulating wildtype RVs in Brazil. |
format |
Article in Journal/Newspaper |
author |
Adriana LUCHS Audrey CILLI Simone Guadagnucci MORILLO Rita de Cássia Compagnoli CARMONA Maria do Carmo Sampaio Tavares TIMENETSKY |
author_facet |
Adriana LUCHS Audrey CILLI Simone Guadagnucci MORILLO Rita de Cássia Compagnoli CARMONA Maria do Carmo Sampaio Tavares TIMENETSKY |
author_sort |
Adriana LUCHS |
title |
ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM |
title_short |
ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM |
title_full |
ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM |
title_fullStr |
ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM |
title_full_unstemmed |
ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM |
title_sort |
rotavirus genotypes circulating in brazil, 2007-2012: implications for the vaccine program |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2015 |
url |
https://doi.org/10.1590/S0036-46652015000400006 https://doaj.org/article/54d08122872e43ecbedb8d555b08ecc3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 57, Iss 4, Pp 305-313 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000400305&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652015000400006 https://doaj.org/article/54d08122872e43ecbedb8d555b08ecc3 |
op_doi |
https://doi.org/10.1590/S0036-46652015000400006 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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57 |
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4 |
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305 |
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