Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort

• Published in: Toxics
• Main Authors: Manhai Long, Maria Wielsøe, Eva Cecilie Bonefeld-Jørgensen
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI AG 2022
• Subjects: persistent organic pollutants; dioxin-like activity; aryl hydrocarbon receptor; Greenlandic Inuit; pregnant women; fetal growth indices; Chemical technology; TP1-1185; greenlandic; inuit
• Online Access: https://doi.org/10.3390/toxics10010026; https://doaj.org/article/54aa9d14aa894b4b995f29c17bfffb3f

Exposure to lipophilic persistent organic pollutants (lipPOPs) elicits a number of species- and tissue-specific toxic responses, many of which involve the aryl hydrocarbon receptor (AhR). This study aims to measure the combined serum dioxin-like activity of lipPOPs in Greenlandic Inuit pregnant women and the associations with fetal growth indices. The combined dioxin-like activity of serum lipPOPs extracts was determined using the AhR reporter gene bioassay and expressed as pico-gram (pg) TCDD equivalent (TEQ) per gram serum lipid [AhR-TEQ (pg/g lipid)]. Significant AhR-TEQ was found in >87% of serum samples with the median level of 86.2 pg TEQ/g lipid. The AhR-TEQ level positively correlated with the marine food intake biomarker n-3/n-6 polyunsaturated fatty acids ratio, while negatively correlated with body mass index and parity. Women giving birth to infants with low birth weight (<2500 g) and length (<50 cm) had higher AhR-TEQ level compared to those with normal weight and length infants. For previous smokers, we found significant inverse associations between maternal AhR-TEQ level and fetal growth indices. In conclusion, exposure of Greenlandic Inuit pregnant women to dioxin-like compounds through traditional marine food can adversely influence the fetal growth via induced AhR activity. Smoking might have modifying effects.