MiRNA-146a polymorphism increases the odds of malaria in pregnancy
Abstract Background Plasmodium falciparum infection during pregnancy is a major cause of poor maternal health, adverse foetal outcome and infant mortality in sub-Saharan Africa. Genetic disposition is involved in susceptibility to malaria in pregnancy and its manifestation. MicroRNAs (miRNAs) influe...
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ftdoajarticles:oai:doaj.org/article:549e8afd942a43c2a5077bf063979c41 2023-05-15T15:16:26+02:00 MiRNA-146a polymorphism increases the odds of malaria in pregnancy Welmoed van Loon Prabhanjan P. Gai Lutz Hamann George Bedu-Addo Frank P. Mockenhaupt 2019-01-01T00:00:00Z https://doi.org/10.1186/s12936-019-2643-z https://doaj.org/article/549e8afd942a43c2a5077bf063979c41 EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2643-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2643-z 1475-2875 https://doaj.org/article/549e8afd942a43c2a5077bf063979c41 Malaria Journal, Vol 18, Iss 1, Pp 1-7 (2019) Malaria Pregnancy Plasmodium falciparum MiRNA-146a Polymorphism Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2643-z 2022-12-30T23:57:31Z Abstract Background Plasmodium falciparum infection during pregnancy is a major cause of poor maternal health, adverse foetal outcome and infant mortality in sub-Saharan Africa. Genetic disposition is involved in susceptibility to malaria in pregnancy and its manifestation. MicroRNAs (miRNAs) influence gene regulation including that of innate immune responses. A miRNA-146a rs2910164 G > C single nucleotide polymorphism (SNP) has been associated with increased risks of several diseases, but no data as to malaria are available. Methods The association between miRNA-146a rs2910164 and P. falciparum infection among 509 Ghanaian women attending antenatal care (ANC) and 296 delivering Ghanaian primiparae was investigated. Malaria parasites were diagnosed by microscopy and PCR. Leukocyte-associated hemozoin in placental samples was recorded as well. Proportions were compared between groups by Fisher’s exact test, and logistic regression models were used to adjust for possible confounders. Results By PCR, P. falciparum infection was detected in 63% and 67% of ANC attendees and delivering primiparae, respectively. In both groups, two in three women were either heterozygous or homozygous for miRNA-146a rs2910164. Among ANC attendees, homozygosity conferred increased odds of infection (adjusted odds ratio (aOR), 2.3; 95% CI, 1.3–4.0), which was pronounced among primigravidae (aOR, 5.8; 95% CI, 1.6–26) but only marginal in multigravidae. Likewise, homozygosity for miRNA-146a rs2910164 in primiparae increased the odds of past or present placental P. falciparum infection almost six-fold (aOR, 5.9; 95% CI, 2.1–18). Conclusions These results indicate that SNP rs2910164 G > C is associated with increased odds for P. falciparum infection in first-time pregnant women who are considered to lack sufficient acquired immune responses against pregnancy-specific strains of P. falciparum. These findings suggest that miRNA-146a is involved in protective malarial immunity, and specifically in the innate component. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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ftdoajarticles |
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English |
topic |
Malaria Pregnancy Plasmodium falciparum MiRNA-146a Polymorphism Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Pregnancy Plasmodium falciparum MiRNA-146a Polymorphism Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Welmoed van Loon Prabhanjan P. Gai Lutz Hamann George Bedu-Addo Frank P. Mockenhaupt MiRNA-146a polymorphism increases the odds of malaria in pregnancy |
topic_facet |
Malaria Pregnancy Plasmodium falciparum MiRNA-146a Polymorphism Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Plasmodium falciparum infection during pregnancy is a major cause of poor maternal health, adverse foetal outcome and infant mortality in sub-Saharan Africa. Genetic disposition is involved in susceptibility to malaria in pregnancy and its manifestation. MicroRNAs (miRNAs) influence gene regulation including that of innate immune responses. A miRNA-146a rs2910164 G > C single nucleotide polymorphism (SNP) has been associated with increased risks of several diseases, but no data as to malaria are available. Methods The association between miRNA-146a rs2910164 and P. falciparum infection among 509 Ghanaian women attending antenatal care (ANC) and 296 delivering Ghanaian primiparae was investigated. Malaria parasites were diagnosed by microscopy and PCR. Leukocyte-associated hemozoin in placental samples was recorded as well. Proportions were compared between groups by Fisher’s exact test, and logistic regression models were used to adjust for possible confounders. Results By PCR, P. falciparum infection was detected in 63% and 67% of ANC attendees and delivering primiparae, respectively. In both groups, two in three women were either heterozygous or homozygous for miRNA-146a rs2910164. Among ANC attendees, homozygosity conferred increased odds of infection (adjusted odds ratio (aOR), 2.3; 95% CI, 1.3–4.0), which was pronounced among primigravidae (aOR, 5.8; 95% CI, 1.6–26) but only marginal in multigravidae. Likewise, homozygosity for miRNA-146a rs2910164 in primiparae increased the odds of past or present placental P. falciparum infection almost six-fold (aOR, 5.9; 95% CI, 2.1–18). Conclusions These results indicate that SNP rs2910164 G > C is associated with increased odds for P. falciparum infection in first-time pregnant women who are considered to lack sufficient acquired immune responses against pregnancy-specific strains of P. falciparum. These findings suggest that miRNA-146a is involved in protective malarial immunity, and specifically in the innate component. |
format |
Article in Journal/Newspaper |
author |
Welmoed van Loon Prabhanjan P. Gai Lutz Hamann George Bedu-Addo Frank P. Mockenhaupt |
author_facet |
Welmoed van Loon Prabhanjan P. Gai Lutz Hamann George Bedu-Addo Frank P. Mockenhaupt |
author_sort |
Welmoed van Loon |
title |
MiRNA-146a polymorphism increases the odds of malaria in pregnancy |
title_short |
MiRNA-146a polymorphism increases the odds of malaria in pregnancy |
title_full |
MiRNA-146a polymorphism increases the odds of malaria in pregnancy |
title_fullStr |
MiRNA-146a polymorphism increases the odds of malaria in pregnancy |
title_full_unstemmed |
MiRNA-146a polymorphism increases the odds of malaria in pregnancy |
title_sort |
mirna-146a polymorphism increases the odds of malaria in pregnancy |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2643-z https://doaj.org/article/549e8afd942a43c2a5077bf063979c41 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-7 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2643-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2643-z 1475-2875 https://doaj.org/article/549e8afd942a43c2a5077bf063979c41 |
op_doi |
https://doi.org/10.1186/s12936-019-2643-z |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
_version_ |
1766346727284015104 |