PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia
Background: The pathogenetic mechanisms of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) are closely related. Currently, multiple studies have demonstrated a link between the PNPLA3 148M variant and the development and progression of NAFLD, including liver fibrosis. The aim of...
Main Authors: | , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
International Medical Research and Development Corporation
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/5441dcd84bb640d7bae062f5635205b1 |
id |
ftdoajarticles:oai:doaj.org/article:5441dcd84bb640d7bae062f5635205b1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5441dcd84bb640d7bae062f5635205b1 2023-05-15T18:44:57+02:00 PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia Khariton A. Kurtanov Nadezhda I. Pavlova Aleksandra T. Diakonova Lyubovy A. Sydykova Sardana V. Markova Vladimir V. Dodokhov 2020-12-01T00:00:00Z https://doaj.org/article/5441dcd84bb640d7bae062f5635205b1 EN eng International Medical Research and Development Corporation http://ijbm.org/articles/i40/ijbm_10(4)_oa21.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 2158-0510 2158-0529 https://doaj.org/article/5441dcd84bb640d7bae062f5635205b1 International Journal of Biomedicine, Vol 10, Iss 4, Pp 438-441 (2020) type 2 diabetes non-alcoholic fatty liver disease pnpla3 rs738409 i148m Medicine R article 2020 ftdoajarticles 2022-12-31T08:16:55Z Background: The pathogenetic mechanisms of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) are closely related. Currently, multiple studies have demonstrated a link between the PNPLA3 148M variant and the development and progression of NAFLD, including liver fibrosis. The aim of our research was to study the distribution of alleles and genotypes of the PNPLA3 rs738409 SNP in Russians and Yakuts living in Yakutia, as well as to search for associations of the PNPLA3 rs738409 SNP in patients with T2D and non-alcoholic fatty liver disease / non-alcoholic steatohepatitis. Methods and Results: The study included 179 patients (28 Russians and 151 Yakuts) with T2D and concomitant liver diseases of non-infectious origin. The comparison group consisted of 147 healthy volunteers of Russian ethnicity and 246 healthy volunteers of Yakut ethnicity. The PNPLA3 738409 SNP was analyzed by PCR-RFLP reaction. The results found a significant difference between the frequencies of the PNPLA3 rs738409 genotypes and alleles in Russians and Yakuts, both among healthy volunteers and in T2D patients with liver diseases. The frequency of the G allele occurrence in the group of healthy Yakuts was significantly higher (OR- 3.313; 95% CI: 2.444-4.499; P<0.001) than in the group of healthy Russians. No significant differences were found for the PNPLA3 rs738409 genotype and allele frequencies among a healthy sample and a sample of T2D patients with non-alcoholic fatty liver disease / non-alcoholic steatohepatitis, both in the Russian and Yakut populations. Article in Journal/Newspaper Yakutia Yakuts Directory of Open Access Journals: DOAJ Articles |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
type 2 diabetes non-alcoholic fatty liver disease pnpla3 rs738409 i148m Medicine R |
spellingShingle |
type 2 diabetes non-alcoholic fatty liver disease pnpla3 rs738409 i148m Medicine R Khariton A. Kurtanov Nadezhda I. Pavlova Aleksandra T. Diakonova Lyubovy A. Sydykova Sardana V. Markova Vladimir V. Dodokhov PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia |
topic_facet |
type 2 diabetes non-alcoholic fatty liver disease pnpla3 rs738409 i148m Medicine R |
description |
Background: The pathogenetic mechanisms of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) are closely related. Currently, multiple studies have demonstrated a link between the PNPLA3 148M variant and the development and progression of NAFLD, including liver fibrosis. The aim of our research was to study the distribution of alleles and genotypes of the PNPLA3 rs738409 SNP in Russians and Yakuts living in Yakutia, as well as to search for associations of the PNPLA3 rs738409 SNP in patients with T2D and non-alcoholic fatty liver disease / non-alcoholic steatohepatitis. Methods and Results: The study included 179 patients (28 Russians and 151 Yakuts) with T2D and concomitant liver diseases of non-infectious origin. The comparison group consisted of 147 healthy volunteers of Russian ethnicity and 246 healthy volunteers of Yakut ethnicity. The PNPLA3 738409 SNP was analyzed by PCR-RFLP reaction. The results found a significant difference between the frequencies of the PNPLA3 rs738409 genotypes and alleles in Russians and Yakuts, both among healthy volunteers and in T2D patients with liver diseases. The frequency of the G allele occurrence in the group of healthy Yakuts was significantly higher (OR- 3.313; 95% CI: 2.444-4.499; P<0.001) than in the group of healthy Russians. No significant differences were found for the PNPLA3 rs738409 genotype and allele frequencies among a healthy sample and a sample of T2D patients with non-alcoholic fatty liver disease / non-alcoholic steatohepatitis, both in the Russian and Yakut populations. |
format |
Article in Journal/Newspaper |
author |
Khariton A. Kurtanov Nadezhda I. Pavlova Aleksandra T. Diakonova Lyubovy A. Sydykova Sardana V. Markova Vladimir V. Dodokhov |
author_facet |
Khariton A. Kurtanov Nadezhda I. Pavlova Aleksandra T. Diakonova Lyubovy A. Sydykova Sardana V. Markova Vladimir V. Dodokhov |
author_sort |
Khariton A. Kurtanov |
title |
PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia |
title_short |
PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia |
title_full |
PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia |
title_fullStr |
PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia |
title_full_unstemmed |
PNPLA3 rs738409 polymorphism in Patients with Type 2 Diabetes and Concomitant Liver Pathology in Yakutia |
title_sort |
pnpla3 rs738409 polymorphism in patients with type 2 diabetes and concomitant liver pathology in yakutia |
publisher |
International Medical Research and Development Corporation |
publishDate |
2020 |
url |
https://doaj.org/article/5441dcd84bb640d7bae062f5635205b1 |
genre |
Yakutia Yakuts |
genre_facet |
Yakutia Yakuts |
op_source |
International Journal of Biomedicine, Vol 10, Iss 4, Pp 438-441 (2020) |
op_relation |
http://ijbm.org/articles/i40/ijbm_10(4)_oa21.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 2158-0510 2158-0529 https://doaj.org/article/5441dcd84bb640d7bae062f5635205b1 |
_version_ |
1766235840073170944 |