Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors.
The mosquito, Aedes aegypti, is highly anthropophilic and transmits debilitating arboviruses within human populations and between humans and non-human primates. Female mosquitoes are attracted to sources of blood by responding to odor plumes that are emitted by their preferred hosts. Acidic volatile...
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ftdoajarticles:oai:doaj.org/article:53ff779ad3e0457b8c2fd919307acf83 2023-07-30T04:01:54+02:00 Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. Garrett Ray Robert M Huff John S Castillo Anthony J Bellantuono Matthew DeGennaro R Jason Pitts 2023-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011402 https://doaj.org/article/53ff779ad3e0457b8c2fd919307acf83 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011402 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011402 https://doaj.org/article/53ff779ad3e0457b8c2fd919307acf83 PLoS Neglected Tropical Diseases, Vol 17, Iss 6, p e0011402 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011402 2023-07-09T00:35:14Z The mosquito, Aedes aegypti, is highly anthropophilic and transmits debilitating arboviruses within human populations and between humans and non-human primates. Female mosquitoes are attracted to sources of blood by responding to odor plumes that are emitted by their preferred hosts. Acidic volatile compounds, including carboxylic acids, represent particularly salient odors driving this attraction. Importantly, carboxylic acids are major constituents of human sweat and volatiles generated by skin microbes. As such, they are likely to impact human host preference, a dominant factor in disease transmission cycles. A more complete understanding of mosquito host attraction will necessitate the elucidation of molecular mechanisms of volatile odor detection that function in peripheral sensory neurons. Recent studies have shown that members of the variant ionotropic glutamate receptor gene family are necessary for physiological and behavioral responses to acidic volatiles in Aedes. In this study, we have identified a subfamily of variant ionotropic receptors that share sequence homology across several important vector species and are likely to be activated by carboxylic acids. Moreover, we demonstrate that selected members of this subfamily are activated by short-chain carboxylic acids in a heterologous cell expression system. Our results are consistent with the hypothesis that members of this receptor class underlie acidic volatile sensitivity in vector mosquitoes and provide a frame of reference for future development of novel mosquito attractant and repellent technologies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 6 e0011402 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Garrett Ray Robert M Huff John S Castillo Anthony J Bellantuono Matthew DeGennaro R Jason Pitts Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The mosquito, Aedes aegypti, is highly anthropophilic and transmits debilitating arboviruses within human populations and between humans and non-human primates. Female mosquitoes are attracted to sources of blood by responding to odor plumes that are emitted by their preferred hosts. Acidic volatile compounds, including carboxylic acids, represent particularly salient odors driving this attraction. Importantly, carboxylic acids are major constituents of human sweat and volatiles generated by skin microbes. As such, they are likely to impact human host preference, a dominant factor in disease transmission cycles. A more complete understanding of mosquito host attraction will necessitate the elucidation of molecular mechanisms of volatile odor detection that function in peripheral sensory neurons. Recent studies have shown that members of the variant ionotropic glutamate receptor gene family are necessary for physiological and behavioral responses to acidic volatiles in Aedes. In this study, we have identified a subfamily of variant ionotropic receptors that share sequence homology across several important vector species and are likely to be activated by carboxylic acids. Moreover, we demonstrate that selected members of this subfamily are activated by short-chain carboxylic acids in a heterologous cell expression system. Our results are consistent with the hypothesis that members of this receptor class underlie acidic volatile sensitivity in vector mosquitoes and provide a frame of reference for future development of novel mosquito attractant and repellent technologies. |
format |
Article in Journal/Newspaper |
author |
Garrett Ray Robert M Huff John S Castillo Anthony J Bellantuono Matthew DeGennaro R Jason Pitts |
author_facet |
Garrett Ray Robert M Huff John S Castillo Anthony J Bellantuono Matthew DeGennaro R Jason Pitts |
author_sort |
Garrett Ray |
title |
Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
title_short |
Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
title_full |
Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
title_fullStr |
Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
title_full_unstemmed |
Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
title_sort |
carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011402 https://doaj.org/article/53ff779ad3e0457b8c2fd919307acf83 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 6, p e0011402 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011402 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011402 https://doaj.org/article/53ff779ad3e0457b8c2fd919307acf83 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011402 |
container_title |
PLOS Neglected Tropical Diseases |
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17 |
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6 |
container_start_page |
e0011402 |
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1772812649453584384 |