Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type
Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOX...
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ftdoajarticles:oai:doaj.org/article:53dce96626c3400a9aa6b612253ca93c 2023-05-15T15:06:26+02:00 Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type Yulieth Cristina Bermúdez Burbano Angie Vanessa Caicedo Paz Cristhian Camilo Rivera Caldon Juan Sebastián Rodríguez Constain Gloria Inés Ávila Gonzáles Julio César Klínger Hernández Nancy Marin-Agudelo Rosa Amalia Dueñas-Cuellar Victoria Eugenia Niño Castaño https://doi.org/10.1590/0037-8682-0101-2019 https://doaj.org/article/53dce96626c3400a9aa6b612253ca93c EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100325&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0101-2019 https://doaj.org/article/53dce96626c3400a9aa6b612253ca93c Revista da Sociedade Brasileira de Medicina Tropical, Vol 52 Tropical Spastic Paraparesis HTLV-1 virus Regulatory T cells Regulatory B cells Interferon-γ Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0101-2019 2022-12-30T23:24:28Z Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. METHODS: The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. RESULTS: Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. CONCLUSIONS: The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 52 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Tropical Spastic Paraparesis HTLV-1 virus Regulatory T cells Regulatory B cells Interferon-γ Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Tropical Spastic Paraparesis HTLV-1 virus Regulatory T cells Regulatory B cells Interferon-γ Arctic medicine. Tropical medicine RC955-962 Yulieth Cristina Bermúdez Burbano Angie Vanessa Caicedo Paz Cristhian Camilo Rivera Caldon Juan Sebastián Rodríguez Constain Gloria Inés Ávila Gonzáles Julio César Klínger Hernández Nancy Marin-Agudelo Rosa Amalia Dueñas-Cuellar Victoria Eugenia Niño Castaño Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
topic_facet |
Tropical Spastic Paraparesis HTLV-1 virus Regulatory T cells Regulatory B cells Interferon-γ Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. METHODS: The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. RESULTS: Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. CONCLUSIONS: The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM. |
format |
Article in Journal/Newspaper |
author |
Yulieth Cristina Bermúdez Burbano Angie Vanessa Caicedo Paz Cristhian Camilo Rivera Caldon Juan Sebastián Rodríguez Constain Gloria Inés Ávila Gonzáles Julio César Klínger Hernández Nancy Marin-Agudelo Rosa Amalia Dueñas-Cuellar Victoria Eugenia Niño Castaño |
author_facet |
Yulieth Cristina Bermúdez Burbano Angie Vanessa Caicedo Paz Cristhian Camilo Rivera Caldon Juan Sebastián Rodríguez Constain Gloria Inés Ávila Gonzáles Julio César Klínger Hernández Nancy Marin-Agudelo Rosa Amalia Dueñas-Cuellar Victoria Eugenia Niño Castaño |
author_sort |
Yulieth Cristina Bermúdez Burbano |
title |
Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
title_short |
Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
title_full |
Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
title_fullStr |
Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
title_full_unstemmed |
Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
title_sort |
low frequency of regulatory b-cells and increased cd4+ and cd8+ interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human t-cell lymphotropic virus type |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0101-2019 https://doaj.org/article/53dce96626c3400a9aa6b612253ca93c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 52 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100325&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0101-2019 https://doaj.org/article/53dce96626c3400a9aa6b612253ca93c |
op_doi |
https://doi.org/10.1590/0037-8682-0101-2019 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
52 |
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