The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus
The thymus is a primary lymphoid organ that plays a pivotal role in the adaptive immune system. The immunobiology of the thymus in fish is considered to be similar to that of mammals, but it is actually poorly characterized in several cultured teleost species. In particular, while investigations in...
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ftdoajarticles:oai:doaj.org/article:53b453ab645a48138d8aedf64afea916 2023-10-01T03:59:19+02:00 The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus Paolo Ronza Diego Robledo Ana Paula Losada Roberto Bermúdez Belén G. Pardo Paulino Martínez María Isabel Quiroga 2020-08-01T00:00:00Z https://doi.org/10.3390/biology9080221 https://doaj.org/article/53b453ab645a48138d8aedf64afea916 EN eng MDPI AG https://www.mdpi.com/2079-7737/9/8/221 https://doaj.org/toc/2079-7737 doi:10.3390/biology9080221 2079-7737 https://doaj.org/article/53b453ab645a48138d8aedf64afea916 Biology, Vol 9, Iss 221, p 221 (2020) fish T lymphocytes infection malnutrition inflammation aquaculture Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.3390/biology9080221 2023-09-03T00:38:48Z The thymus is a primary lymphoid organ that plays a pivotal role in the adaptive immune system. The immunobiology of the thymus in fish is considered to be similar to that of mammals, but it is actually poorly characterized in several cultured teleost species. In particular, while investigations in human and veterinary medicine have highlighted that the thymus can be affected by different pathological conditions, little is known about its response during disease in fish. To better understand the role of the thymus under physiological and pathological conditions, we conducted a study in turbot ( Scophthalmus maximus ), a commercially valuable flatfish species, combining transcriptomic and histopathological analyses. The myxozoan parasite Enteromyxum scophthalmi , which represents a major challenge to turbot production, was used as a model of infection. The thymus tissues of healthy fish showed overrepresented functions related to its immunological role in T-cell development and maturation. Large differences were observed between the transcriptomes of control and severely infected fish. Evidence of inflammatory response, apoptosis modulation, and declined thymic function associated with loss of cellularity was revealed by both genomic and morphopathological analyses. This study presents the first description of the turbot thymus transcriptome and provides novel insights into the role of this organ in teleosts’ immune responses. Article in Journal/Newspaper Scophthalmus maximus Turbot Directory of Open Access Journals: DOAJ Articles Biology 9 8 221 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
fish T lymphocytes infection malnutrition inflammation aquaculture Biology (General) QH301-705.5 |
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fish T lymphocytes infection malnutrition inflammation aquaculture Biology (General) QH301-705.5 Paolo Ronza Diego Robledo Ana Paula Losada Roberto Bermúdez Belén G. Pardo Paulino Martínez María Isabel Quiroga The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus |
topic_facet |
fish T lymphocytes infection malnutrition inflammation aquaculture Biology (General) QH301-705.5 |
description |
The thymus is a primary lymphoid organ that plays a pivotal role in the adaptive immune system. The immunobiology of the thymus in fish is considered to be similar to that of mammals, but it is actually poorly characterized in several cultured teleost species. In particular, while investigations in human and veterinary medicine have highlighted that the thymus can be affected by different pathological conditions, little is known about its response during disease in fish. To better understand the role of the thymus under physiological and pathological conditions, we conducted a study in turbot ( Scophthalmus maximus ), a commercially valuable flatfish species, combining transcriptomic and histopathological analyses. The myxozoan parasite Enteromyxum scophthalmi , which represents a major challenge to turbot production, was used as a model of infection. The thymus tissues of healthy fish showed overrepresented functions related to its immunological role in T-cell development and maturation. Large differences were observed between the transcriptomes of control and severely infected fish. Evidence of inflammatory response, apoptosis modulation, and declined thymic function associated with loss of cellularity was revealed by both genomic and morphopathological analyses. This study presents the first description of the turbot thymus transcriptome and provides novel insights into the role of this organ in teleosts’ immune responses. |
format |
Article in Journal/Newspaper |
author |
Paolo Ronza Diego Robledo Ana Paula Losada Roberto Bermúdez Belén G. Pardo Paulino Martínez María Isabel Quiroga |
author_facet |
Paolo Ronza Diego Robledo Ana Paula Losada Roberto Bermúdez Belén G. Pardo Paulino Martínez María Isabel Quiroga |
author_sort |
Paolo Ronza |
title |
The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus |
title_short |
The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus |
title_full |
The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus |
title_fullStr |
The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus |
title_full_unstemmed |
The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus |
title_sort |
teleost thymus in health and disease: new insights from transcriptomic and histopathological analyses of turbot, scophthalmus maximus |
publisher |
MDPI AG |
publishDate |
2020 |
url |
https://doi.org/10.3390/biology9080221 https://doaj.org/article/53b453ab645a48138d8aedf64afea916 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Biology, Vol 9, Iss 221, p 221 (2020) |
op_relation |
https://www.mdpi.com/2079-7737/9/8/221 https://doaj.org/toc/2079-7737 doi:10.3390/biology9080221 2079-7737 https://doaj.org/article/53b453ab645a48138d8aedf64afea916 |
op_doi |
https://doi.org/10.3390/biology9080221 |
container_title |
Biology |
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9 |
container_issue |
8 |
container_start_page |
221 |
_version_ |
1778533231649357824 |