Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus)
Deratisation is one of the basic anti-epidemic measures, directed to protect the health of humans and animals. Nowadays, anticoagulants are still the most commonly used rodenticides. In recent years, the problem of development of resistant synanthropic rodents to these agents is becoming more seriou...
Published in: | Trakia Journal of Science |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Trakia University
2018
|
Subjects: | |
Online Access: | https://doi.org/10.15547/tjs.2018.01.005 https://doaj.org/article/538bda76abcd4a35a14bf8df866739ab |
id |
ftdoajarticles:oai:doaj.org/article:538bda76abcd4a35a14bf8df866739ab |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:538bda76abcd4a35a14bf8df866739ab 2023-05-15T18:05:04+02:00 Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) G. Zhelev K. Koev Vl. Petrov 2018-03-01T00:00:00Z https://doi.org/10.15547/tjs.2018.01.005 https://doaj.org/article/538bda76abcd4a35a14bf8df866739ab EN eng Trakia University http://tru.uni-sz.bg/tsj/N%201,%20Vol.16,%202018/G.Zhelev%20(1).pdf https://doaj.org/toc/1312-1723 https://doaj.org/toc/1313-3551 doi:10.15547/tjs.2018.01.005 1312-1723 1313-3551 https://doaj.org/article/538bda76abcd4a35a14bf8df866739ab Trakia Journal of Sciences, Vol 16, Iss 1, Pp 22-26 (2018) indomethacin rodenticide anticoagulant resistance deratisation Science (General) Q1-390 article 2018 ftdoajarticles https://doi.org/10.15547/tjs.2018.01.005 2022-12-30T21:47:54Z Deratisation is one of the basic anti-epidemic measures, directed to protect the health of humans and animals. Nowadays, anticoagulants are still the most commonly used rodenticides. In recent years, the problem of development of resistant synanthropic rodents to these agents is becoming more serious. This is the reason for increasing interest in discovering alternative methods for controlling the resistant populations. It is known that some non-steroidal anti-inflammatory drugs (NSAIDs) act as synergists and significantly increase the toxicity of anticoagulant rodenticides, but convincing information on their effectiveness in anticoagulant-resistant rodents is still missing. The aim of the present research is to contribute to solve this problem, by studying the effectiveness of 0.025% indomethacin baits, administered alone and combined with warfarin, in warfarin-resistant wild synanthropic rodents. In the conducted laboratory food tests 36 roof rats (Rattus rattus) and 60 house mice (Mus musculus) were included. A very high toxicity of indomethacin baits in resistant rodents, leading up to 100% mortality, occurring between 24 to 48 hours post acceptance were found. NSAIDs mechanism of action, clinical signs and pathological findings in the intoxicated rodents are discussed. Based on the laboratory conducted tests and scientific data analysis, we conclude that 0.025% indomethacin baits have high effectiveness in anticoagulant-resistant synanthropic rodents and could be used as an alternative method for control of resistant populations. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles Trakia Journal of Science 16 1 22 26 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
indomethacin rodenticide anticoagulant resistance deratisation Science (General) Q1-390 |
spellingShingle |
indomethacin rodenticide anticoagulant resistance deratisation Science (General) Q1-390 G. Zhelev K. Koev Vl. Petrov Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) |
topic_facet |
indomethacin rodenticide anticoagulant resistance deratisation Science (General) Q1-390 |
description |
Deratisation is one of the basic anti-epidemic measures, directed to protect the health of humans and animals. Nowadays, anticoagulants are still the most commonly used rodenticides. In recent years, the problem of development of resistant synanthropic rodents to these agents is becoming more serious. This is the reason for increasing interest in discovering alternative methods for controlling the resistant populations. It is known that some non-steroidal anti-inflammatory drugs (NSAIDs) act as synergists and significantly increase the toxicity of anticoagulant rodenticides, but convincing information on their effectiveness in anticoagulant-resistant rodents is still missing. The aim of the present research is to contribute to solve this problem, by studying the effectiveness of 0.025% indomethacin baits, administered alone and combined with warfarin, in warfarin-resistant wild synanthropic rodents. In the conducted laboratory food tests 36 roof rats (Rattus rattus) and 60 house mice (Mus musculus) were included. A very high toxicity of indomethacin baits in resistant rodents, leading up to 100% mortality, occurring between 24 to 48 hours post acceptance were found. NSAIDs mechanism of action, clinical signs and pathological findings in the intoxicated rodents are discussed. Based on the laboratory conducted tests and scientific data analysis, we conclude that 0.025% indomethacin baits have high effectiveness in anticoagulant-resistant synanthropic rodents and could be used as an alternative method for control of resistant populations. |
format |
Article in Journal/Newspaper |
author |
G. Zhelev K. Koev Vl. Petrov |
author_facet |
G. Zhelev K. Koev Vl. Petrov |
author_sort |
G. Zhelev |
title |
Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) |
title_short |
Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) |
title_full |
Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) |
title_fullStr |
Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) |
title_full_unstemmed |
Rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (Rattus Rattus) and house mice (Mus Musculus) |
title_sort |
rodenticidal effectiveness of indomethacin baits in warfarin-resistant roof rats (rattus rattus) and house mice (mus musculus) |
publisher |
Trakia University |
publishDate |
2018 |
url |
https://doi.org/10.15547/tjs.2018.01.005 https://doaj.org/article/538bda76abcd4a35a14bf8df866739ab |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Trakia Journal of Sciences, Vol 16, Iss 1, Pp 22-26 (2018) |
op_relation |
http://tru.uni-sz.bg/tsj/N%201,%20Vol.16,%202018/G.Zhelev%20(1).pdf https://doaj.org/toc/1312-1723 https://doaj.org/toc/1313-3551 doi:10.15547/tjs.2018.01.005 1312-1723 1313-3551 https://doaj.org/article/538bda76abcd4a35a14bf8df866739ab |
op_doi |
https://doi.org/10.15547/tjs.2018.01.005 |
container_title |
Trakia Journal of Science |
container_volume |
16 |
container_issue |
1 |
container_start_page |
22 |
op_container_end_page |
26 |
_version_ |
1766176501359706112 |