Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites.
BACKGROUND: The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable bi...
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ftdoajarticles:oai:doaj.org/article:53604190c0c941b8a390f343d396c103 2023-05-15T15:08:09+02:00 Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. Souleymane Doucoure François Mouchet Sylvie Cornelie Jean Sébastien DeHecq Abdul Hamid Rutee Yelin Roca Annie Walter Jean Pierre Hervé Dorothée Misse François Favier Philippe Gasque Franck Remoue 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001487 https://doaj.org/article/53604190c0c941b8a390f343d396c103 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3283547?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001487 https://doaj.org/article/53604190c0c941b8a390f343d396c103 PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1487 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001487 2022-12-31T01:32:38Z BACKGROUND: The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs. METHODOLOGY/PRINCIPAL FINDINGS: We used ELISA tests to evaluate specific immunoglobulin G (IgG) responses to salivary gland extracts (SGE) in adults exposed to Aedes albopictus in Reunion Island. The percentage of immune responders (88%) and levels of anti-SGE IgG Abs were high in exposed individuals. At an individual level, our results indicate heterogeneity of the exposure to Aedes albopictus bites. In addition, low-level immune cross-reactivity between Aedes albopictus and Aedes aegypti SGEs was observed, mainly in the highest responders. CONCLUSION/SIGNIFICANCE: Ab responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to Aedes albopictus bites. Combined with entomological and epidemiological methods, a "salivary" biomarker of exposure to Aedes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the evaluation of Aedes albopictus control strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 2 e1487 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Souleymane Doucoure François Mouchet Sylvie Cornelie Jean Sébastien DeHecq Abdul Hamid Rutee Yelin Roca Annie Walter Jean Pierre Hervé Dorothée Misse François Favier Philippe Gasque Franck Remoue Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs. METHODOLOGY/PRINCIPAL FINDINGS: We used ELISA tests to evaluate specific immunoglobulin G (IgG) responses to salivary gland extracts (SGE) in adults exposed to Aedes albopictus in Reunion Island. The percentage of immune responders (88%) and levels of anti-SGE IgG Abs were high in exposed individuals. At an individual level, our results indicate heterogeneity of the exposure to Aedes albopictus bites. In addition, low-level immune cross-reactivity between Aedes albopictus and Aedes aegypti SGEs was observed, mainly in the highest responders. CONCLUSION/SIGNIFICANCE: Ab responses to saliva could be used as an immuno-epidemiological tool for evaluating exposure to Aedes albopictus bites. Combined with entomological and epidemiological methods, a "salivary" biomarker of exposure to Aedes albopictus could enhance surveillance of its spread and the risk of arbovirus transmission, and could be used as a direct tool for the evaluation of Aedes albopictus control strategies. |
format |
Article in Journal/Newspaper |
author |
Souleymane Doucoure François Mouchet Sylvie Cornelie Jean Sébastien DeHecq Abdul Hamid Rutee Yelin Roca Annie Walter Jean Pierre Hervé Dorothée Misse François Favier Philippe Gasque Franck Remoue |
author_facet |
Souleymane Doucoure François Mouchet Sylvie Cornelie Jean Sébastien DeHecq Abdul Hamid Rutee Yelin Roca Annie Walter Jean Pierre Hervé Dorothée Misse François Favier Philippe Gasque Franck Remoue |
author_sort |
Souleymane Doucoure |
title |
Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
title_short |
Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
title_full |
Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
title_fullStr |
Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
title_full_unstemmed |
Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
title_sort |
evaluation of the human igg antibody response to aedes albopictus saliva as a new specific biomarker of exposure to vector bites. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001487 https://doaj.org/article/53604190c0c941b8a390f343d396c103 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1487 (2012) |
op_relation |
http://europepmc.org/articles/PMC3283547?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001487 https://doaj.org/article/53604190c0c941b8a390f343d396c103 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001487 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
6 |
container_issue |
2 |
container_start_page |
e1487 |
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1766339566426390528 |