Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat
Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis (R. officinalis) in ethanol-induced gastric ulcer model in vivo. Methods: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induc...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.apjtb.2015.09.027 https://doaj.org/article/535fa543551d4cd3a9bc73274587d684 |
id |
ftdoajarticles:oai:doaj.org/article:535fa543551d4cd3a9bc73274587d684 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:535fa543551d4cd3a9bc73274587d684 2023-05-15T15:09:50+02:00 Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo José Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista Marcos José Salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira 2016-08-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.09.027 https://doaj.org/article/535fa543551d4cd3a9bc73274587d684 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116000083 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.027 https://doaj.org/article/535fa543551d4cd3a9bc73274587d684 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 8, Pp 677-681 (2016) Rosmarinus officinalis L Antioxidant activity Gastric ulcer Antioxidant enzymes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.09.027 2022-12-31T07:15:23Z Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis (R. officinalis) in ethanol-induced gastric ulcer model in vivo. Methods: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were measured. Results: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of (140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis (50 mg/kg, p.o.), a significant inhibition of mucosal injury of (21.2 ± 7.1) mm2 (84% inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes (superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition, lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole (28.5%), camphor (27.7%) and alpha-pinene (21.3%). Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 8 677 681 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Rosmarinus officinalis L Antioxidant activity Gastric ulcer Antioxidant enzymes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Rosmarinus officinalis L Antioxidant activity Gastric ulcer Antioxidant enzymes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo José Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista Marcos José Salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
topic_facet |
Rosmarinus officinalis L Antioxidant activity Gastric ulcer Antioxidant enzymes Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis (R. officinalis) in ethanol-induced gastric ulcer model in vivo. Methods: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were measured. Results: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of (140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis (50 mg/kg, p.o.), a significant inhibition of mucosal injury of (21.2 ± 7.1) mm2 (84% inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes (superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition, lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole (28.5%), camphor (27.7%) and alpha-pinene (21.3%). Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis. |
format |
Article in Journal/Newspaper |
author |
Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo José Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista Marcos José Salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira |
author_facet |
Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo José Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista Marcos José Salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira |
author_sort |
Christiane Takayama |
title |
Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
title_short |
Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
title_full |
Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
title_fullStr |
Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
title_full_unstemmed |
Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
title_sort |
chemical composition of rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.09.027 https://doaj.org/article/535fa543551d4cd3a9bc73274587d684 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 8, Pp 677-681 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116000083 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.027 https://doaj.org/article/535fa543551d4cd3a9bc73274587d684 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.09.027 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
8 |
container_start_page |
677 |
op_container_end_page |
681 |
_version_ |
1766340944884400128 |