Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats
Objective: To explore the effects of a nano-formulation of curcumin (phytosomal curcumin) on the clinical and pathological symptoms of collagen-induced arthritis (CIA) in rats. Methods: Forty male Wistar rats were immunized with an emulsion containing bovine type II collagen and incomplete Freund...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2022
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ftdoajarticles:oai:doaj.org/article:535d211ed5aa49dd9f1317bd47d10023 2023-05-15T15:05:40+02:00 Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats Mahnaz Ramezani Nahid Zainodini Reza Nosratabadi Yaser Yousefpoor Zahra Taghipour Mitra Abbasifard Mohammad Reza Rahmani 2022-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.360562 https://doaj.org/article/535d211ed5aa49dd9f1317bd47d10023 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=11;spage=466;epage=474;aulast=Ramezani https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.360562 https://doaj.org/article/535d211ed5aa49dd9f1317bd47d10023 Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 11, Pp 466-474 (2022) phytosomal curcumin rheumatoid arthritis collagen th17 treg anti-inflammation curcuma longa Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.4103/2221-1691.360562 2022-12-30T19:34:48Z Objective: To explore the effects of a nano-formulation of curcumin (phytosomal curcumin) on the clinical and pathological symptoms of collagen-induced arthritis (CIA) in rats. Methods: Forty male Wistar rats were immunized with an emulsion containing bovine type II collagen and incomplete Freund's adjuvant and then administered phytosomal curcumin post-immunization. Clinical symptoms and histological analysis of the synovial tissues were performed. The effect of phytosomal curcumin on Th17 and Treg parameters was also evaluated. Results: Phytosomal curcumin reduced the clinical severity and paw swelling in CIA-induced rats, which was accompanied by a reduction in the number of inflammatory cell infiltration in the synovial tissue. Additionally, treatment with phytosomal curcumin significantly inhibited CIA-associated mediators as well as increased the anti-inflammatory mediators in comparison to the control groups. Conclusions: Phytosomal curcumin could improve CIA autoimmune responses and can be considered a potential candidate for the treatment of rheumatoid arthritis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 12 11 466 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
phytosomal curcumin rheumatoid arthritis collagen th17 treg anti-inflammation curcuma longa Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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phytosomal curcumin rheumatoid arthritis collagen th17 treg anti-inflammation curcuma longa Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Mahnaz Ramezani Nahid Zainodini Reza Nosratabadi Yaser Yousefpoor Zahra Taghipour Mitra Abbasifard Mohammad Reza Rahmani Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats |
topic_facet |
phytosomal curcumin rheumatoid arthritis collagen th17 treg anti-inflammation curcuma longa Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To explore the effects of a nano-formulation of curcumin (phytosomal curcumin) on the clinical and pathological symptoms of collagen-induced arthritis (CIA) in rats. Methods: Forty male Wistar rats were immunized with an emulsion containing bovine type II collagen and incomplete Freund's adjuvant and then administered phytosomal curcumin post-immunization. Clinical symptoms and histological analysis of the synovial tissues were performed. The effect of phytosomal curcumin on Th17 and Treg parameters was also evaluated. Results: Phytosomal curcumin reduced the clinical severity and paw swelling in CIA-induced rats, which was accompanied by a reduction in the number of inflammatory cell infiltration in the synovial tissue. Additionally, treatment with phytosomal curcumin significantly inhibited CIA-associated mediators as well as increased the anti-inflammatory mediators in comparison to the control groups. Conclusions: Phytosomal curcumin could improve CIA autoimmune responses and can be considered a potential candidate for the treatment of rheumatoid arthritis. |
format |
Article in Journal/Newspaper |
author |
Mahnaz Ramezani Nahid Zainodini Reza Nosratabadi Yaser Yousefpoor Zahra Taghipour Mitra Abbasifard Mohammad Reza Rahmani |
author_facet |
Mahnaz Ramezani Nahid Zainodini Reza Nosratabadi Yaser Yousefpoor Zahra Taghipour Mitra Abbasifard Mohammad Reza Rahmani |
author_sort |
Mahnaz Ramezani |
title |
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats |
title_short |
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats |
title_full |
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats |
title_fullStr |
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats |
title_full_unstemmed |
Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats |
title_sort |
phytosomal curcumin alleviates collagen-induced arthritis by downregulating th17 and upregulating treg cell responses in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/2221-1691.360562 https://doaj.org/article/535d211ed5aa49dd9f1317bd47d10023 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 11, Pp 466-474 (2022) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=11;spage=466;epage=474;aulast=Ramezani https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.360562 https://doaj.org/article/535d211ed5aa49dd9f1317bd47d10023 |
op_doi |
https://doi.org/10.4103/2221-1691.360562 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
12 |
container_issue |
11 |
container_start_page |
466 |
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1766337323415371776 |