Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats
Objective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/k...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Wolters Kluwer Medknow Publications
2018
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Online Access: | https://doi.org/10.4103/1995-7645.242310 https://doaj.org/article/5327d2dc3aeb4af6adb52d4f37bb993e |
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ftdoajarticles:oai:doaj.org/article:5327d2dc3aeb4af6adb52d4f37bb993e 2023-05-15T15:05:33+02:00 Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.242310 https://doaj.org/article/5327d2dc3aeb4af6adb52d4f37bb993e EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=9;spage=518;epage=525;aulast=Mishra https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.242310 https://doaj.org/article/5327d2dc3aeb4af6adb52d4f37bb993e Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 9, Pp 518-525 (2018) antituberculosis drugs hepatic injury pergularia daemia antioxidant activity Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.242310 2022-12-31T14:21:47Z Objective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/kg, p.o.) were conjointly administered for 8 weeks and various biochemical, histoarchitectural, ultrastructural studies were performed. Results: Administration of ATDs significantly increased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, cholesterol, bilirubin and decreased glucose and albumin level. Increased lipid peroxidation and reduction in glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure. Administration of P. daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent manner. Histological and ultra-structural observations substantiated biochemical findings. Conclusions: P. daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 9 518 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
antituberculosis drugs hepatic injury pergularia daemia antioxidant activity Arctic medicine. Tropical medicine RC955-962 |
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antituberculosis drugs hepatic injury pergularia daemia antioxidant activity Arctic medicine. Tropical medicine RC955-962 Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
topic_facet |
antituberculosis drugs hepatic injury pergularia daemia antioxidant activity Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/kg, p.o.) were conjointly administered for 8 weeks and various biochemical, histoarchitectural, ultrastructural studies were performed. Results: Administration of ATDs significantly increased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, cholesterol, bilirubin and decreased glucose and albumin level. Increased lipid peroxidation and reduction in glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure. Administration of P. daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent manner. Histological and ultra-structural observations substantiated biochemical findings. Conclusions: P. daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies. |
format |
Article in Journal/Newspaper |
author |
Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria |
author_facet |
Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria |
author_sort |
Gita Mishra |
title |
Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
title_short |
Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
title_full |
Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
title_fullStr |
Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
title_full_unstemmed |
Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
title_sort |
ameliorative effect of pergularia daemia (forssk.) chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.242310 https://doaj.org/article/5327d2dc3aeb4af6adb52d4f37bb993e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 9, Pp 518-525 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=9;spage=518;epage=525;aulast=Mishra https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.242310 https://doaj.org/article/5327d2dc3aeb4af6adb52d4f37bb993e |
op_doi |
https://doi.org/10.4103/1995-7645.242310 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
9 |
container_start_page |
518 |
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1766337228889391104 |