Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C
Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to de...
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ftdoajarticles:oai:doaj.org/article:5305be42f40e4f309413b9220b7e8fed 2023-05-15T15:01:36+02:00 Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C Aline Aki Tanikawa Rejane Maria Tommasini Grotto Giovanni Faria Silva Adriana Camargo Ferrasi Valéria Cristina Rodrigues Sarnighausen Maria Inês de Moura Campos Pardini https://doi.org/10.1590/0037-8682-0302-2016 https://doaj.org/article/5305be42f40e4f309413b9220b7e8fed EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100113&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0302-2016 https://doaj.org/article/5305be42f40e4f309413b9220b7e8fed Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 113-116 Hepatic fibrosis PDGF TGFB Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0302-2016 2022-12-31T02:59:03Z Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. RESULTS: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. CONCLUSIONS: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 1 113 116 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Hepatic fibrosis PDGF TGFB Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Hepatic fibrosis PDGF TGFB Arctic medicine. Tropical medicine RC955-962 Aline Aki Tanikawa Rejane Maria Tommasini Grotto Giovanni Faria Silva Adriana Camargo Ferrasi Valéria Cristina Rodrigues Sarnighausen Maria Inês de Moura Campos Pardini Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
topic_facet |
Hepatic fibrosis PDGF TGFB Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. RESULTS: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. CONCLUSIONS: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis. |
format |
Article in Journal/Newspaper |
author |
Aline Aki Tanikawa Rejane Maria Tommasini Grotto Giovanni Faria Silva Adriana Camargo Ferrasi Valéria Cristina Rodrigues Sarnighausen Maria Inês de Moura Campos Pardini |
author_facet |
Aline Aki Tanikawa Rejane Maria Tommasini Grotto Giovanni Faria Silva Adriana Camargo Ferrasi Valéria Cristina Rodrigues Sarnighausen Maria Inês de Moura Campos Pardini |
author_sort |
Aline Aki Tanikawa |
title |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
title_short |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
title_full |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
title_fullStr |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
title_full_unstemmed |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
title_sort |
platelet-derived growth factor a mrna in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis c |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0302-2016 https://doaj.org/article/5305be42f40e4f309413b9220b7e8fed |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 113-116 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100113&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0302-2016 https://doaj.org/article/5305be42f40e4f309413b9220b7e8fed |
op_doi |
https://doi.org/10.1590/0037-8682-0302-2016 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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50 |
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113 |
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116 |
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