An economic evaluation of Wolbachia deployments for dengue control in Vietnam.
Introduction Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of...
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ftdoajarticles:oai:doaj.org/article:52f3b1dd33de44b1bc476cdf7d7305a0 2024-09-09T19:27:12+00:00 An economic evaluation of Wolbachia deployments for dengue control in Vietnam. Hugo C Turner Duong Le Quyen Reynold Dias Phan Thi Huong Cameron P Simmons Katherine L Anders 2023-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011356 https://doaj.org/article/52f3b1dd33de44b1bc476cdf7d7305a0 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011356&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011356 https://doaj.org/article/52f3b1dd33de44b1bc476cdf7d7305a0 PLoS Neglected Tropical Diseases, Vol 17, Iss 5, p e0011356 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011356 2024-08-05T17:49:01Z Introduction Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control in Vietnam-targeted at the highest burden urban areas. Methods Ten settings within Vietnam were identified as priority locations for potential future Wolbachia deployments (using a population replacement strategy). The effectiveness of Wolbachia deployments in reducing the incidence of symptomatic dengue cases was assumed to be 75%. We assumed that the intervention would maintain this effectiveness for at least 20 years (but tested this assumption in the sensitivity analysis). A cost-utility analysis and cost-benefit analysis were conducted. Results From the health sector perspective, the Wolbachia intervention was projected to cost US$420 per disability-adjusted life year (DALY) averted. From the societal perspective, the overall cost-effectiveness ratio was negative, i.e. the economic benefits outweighed the costs. These results are contingent on the long-term effectiveness of Wolbachia releases being sustained for 20 years. However, the intervention was still classed as cost-effective across the majority of the settings when assuming only 10 years of benefits. Conclusion Overall, we found that targeting high burden cities with Wolbachia deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains. Article in Journal/Newspaper Arctic Climate change Directory of Open Access Journals: DOAJ Articles Arctic Daly ENVELOPE(63.761,63.761,-67.513,-67.513) PLOS Neglected Tropical Diseases 17 5 e0011356 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hugo C Turner Duong Le Quyen Reynold Dias Phan Thi Huong Cameron P Simmons Katherine L Anders An economic evaluation of Wolbachia deployments for dengue control in Vietnam. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Introduction Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control in Vietnam-targeted at the highest burden urban areas. Methods Ten settings within Vietnam were identified as priority locations for potential future Wolbachia deployments (using a population replacement strategy). The effectiveness of Wolbachia deployments in reducing the incidence of symptomatic dengue cases was assumed to be 75%. We assumed that the intervention would maintain this effectiveness for at least 20 years (but tested this assumption in the sensitivity analysis). A cost-utility analysis and cost-benefit analysis were conducted. Results From the health sector perspective, the Wolbachia intervention was projected to cost US$420 per disability-adjusted life year (DALY) averted. From the societal perspective, the overall cost-effectiveness ratio was negative, i.e. the economic benefits outweighed the costs. These results are contingent on the long-term effectiveness of Wolbachia releases being sustained for 20 years. However, the intervention was still classed as cost-effective across the majority of the settings when assuming only 10 years of benefits. Conclusion Overall, we found that targeting high burden cities with Wolbachia deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains. |
format |
Article in Journal/Newspaper |
author |
Hugo C Turner Duong Le Quyen Reynold Dias Phan Thi Huong Cameron P Simmons Katherine L Anders |
author_facet |
Hugo C Turner Duong Le Quyen Reynold Dias Phan Thi Huong Cameron P Simmons Katherine L Anders |
author_sort |
Hugo C Turner |
title |
An economic evaluation of Wolbachia deployments for dengue control in Vietnam. |
title_short |
An economic evaluation of Wolbachia deployments for dengue control in Vietnam. |
title_full |
An economic evaluation of Wolbachia deployments for dengue control in Vietnam. |
title_fullStr |
An economic evaluation of Wolbachia deployments for dengue control in Vietnam. |
title_full_unstemmed |
An economic evaluation of Wolbachia deployments for dengue control in Vietnam. |
title_sort |
economic evaluation of wolbachia deployments for dengue control in vietnam. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011356 https://doaj.org/article/52f3b1dd33de44b1bc476cdf7d7305a0 |
long_lat |
ENVELOPE(63.761,63.761,-67.513,-67.513) |
geographic |
Arctic Daly |
geographic_facet |
Arctic Daly |
genre |
Arctic Climate change |
genre_facet |
Arctic Climate change |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 5, p e0011356 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011356&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011356 https://doaj.org/article/52f3b1dd33de44b1bc476cdf7d7305a0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011356 |
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PLOS Neglected Tropical Diseases |
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17 |
container_issue |
5 |
container_start_page |
e0011356 |
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