Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots
One of the important treatment landscape widely used for the various disease’s management is phytotherapy, or treatment with herbal medicines. Phytotherapy is used as an independent type of treatment in most cases, and in combination with other drugs as additional treatment. The pain and inflammatio...
Published in: | Farmatsevtychnyi zhurnal |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | Ukrainian |
Published: |
The State Expert Center of the Ministry of Health of Ukraine
2021
|
Subjects: | |
Online Access: | https://doi.org/10.32352/0367-3057.4.21.09 https://doaj.org/article/52eb9a021f924e019a0a334fe3bf2fd5 |
id |
ftdoajarticles:oai:doaj.org/article:52eb9a021f924e019a0a334fe3bf2fd5 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:52eb9a021f924e019a0a334fe3bf2fd5 2023-05-15T18:08:55+02:00 Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots L. Maloshtan K. Artemova O. Shatalova 2021-08-01T00:00:00Z https://doi.org/10.32352/0367-3057.4.21.09 https://doaj.org/article/52eb9a021f924e019a0a334fe3bf2fd5 UK ukr The State Expert Center of the Ministry of Health of Ukraine https://pharmj.org.ua/index.php/journal/article/view/1242/1143 https://doaj.org/toc/0367-3057 https://doaj.org/toc/2617-9628 doi:10.32352/0367-3057.4.21.09 0367-3057 2617-9628 https://doaj.org/article/52eb9a021f924e019a0a334fe3bf2fd5 Фармацевтичний журнал, Vol 4, Pp 103-110 (2021) sakhalin willow shoots dry extract analgesic activity anti-inflammatory activity Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 article 2021 ftdoajarticles https://doi.org/10.32352/0367-3057.4.21.09 2022-12-31T09:18:19Z One of the important treatment landscape widely used for the various disease’s management is phytotherapy, or treatment with herbal medicines. Phytotherapy is used as an independent type of treatment in most cases, and in combination with other drugs as additional treatment. The pain and inflammation control continue as long as there is humanity itself. With old experience of traditional medicine know that Salicaceae have a pronounced anti-inflammatory and analgesic effects. The pharmacological study of the dry extract from Sakhalin willow shoots – the study of analgesic and anti-inflammatory activities in different pharmacological models – was the aim of this work. The analgesic and anti-inflammatory activity of the standardized dry extract from Sakhalin willow shoots (DESWS) was experimentally researched. The study of pharmacological activities of DESWS was carried out at the Educational and Scientific Institute of Applied Pharmacy of the National University of Pharmacy (Kharkov). The effect of DESWS on the course of the inflammatory process was studied in a model of carrageenan edema. Analgesic activity was studied in a model of thermal irritation in white male rats. The study of anti-inflammatory activity in rats on a model of carrageenan edema showed that an effective dose of the studied extract was 30 mg/kg. The greatest reduction in paw edema in rats on the model of carrageenan edema in the first hour of the experiment was observed in the group of animals treated with DESWS at a dose of 30 mg/kg. The anti-inflammatory activity of DESWS was 53.74%, but it was slightly inferior than in the reference drug Diclofenac. It was found that DESWS also shows pronounced analgesic properties at a dose of 30 mg/kg during the first and second hours of the experiment in the model of the limb’s thermal irritation «Hot Plate» in rats. After 120 minutes of experiment the studied activity didn’t change significantly and remained at the level 62.6%. The analgesic effect of DESWS was inferior to antinociceptive activity of ... Article in Journal/Newspaper Sakhalin Directory of Open Access Journals: DOAJ Articles Farmatsevtychnyi zhurnal 4 103 110 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Ukrainian |
topic |
sakhalin willow shoots dry extract analgesic activity anti-inflammatory activity Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 |
spellingShingle |
sakhalin willow shoots dry extract analgesic activity anti-inflammatory activity Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 L. Maloshtan K. Artemova O. Shatalova Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
topic_facet |
sakhalin willow shoots dry extract analgesic activity anti-inflammatory activity Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 |
description |
One of the important treatment landscape widely used for the various disease’s management is phytotherapy, or treatment with herbal medicines. Phytotherapy is used as an independent type of treatment in most cases, and in combination with other drugs as additional treatment. The pain and inflammation control continue as long as there is humanity itself. With old experience of traditional medicine know that Salicaceae have a pronounced anti-inflammatory and analgesic effects. The pharmacological study of the dry extract from Sakhalin willow shoots – the study of analgesic and anti-inflammatory activities in different pharmacological models – was the aim of this work. The analgesic and anti-inflammatory activity of the standardized dry extract from Sakhalin willow shoots (DESWS) was experimentally researched. The study of pharmacological activities of DESWS was carried out at the Educational and Scientific Institute of Applied Pharmacy of the National University of Pharmacy (Kharkov). The effect of DESWS on the course of the inflammatory process was studied in a model of carrageenan edema. Analgesic activity was studied in a model of thermal irritation in white male rats. The study of anti-inflammatory activity in rats on a model of carrageenan edema showed that an effective dose of the studied extract was 30 mg/kg. The greatest reduction in paw edema in rats on the model of carrageenan edema in the first hour of the experiment was observed in the group of animals treated with DESWS at a dose of 30 mg/kg. The anti-inflammatory activity of DESWS was 53.74%, but it was slightly inferior than in the reference drug Diclofenac. It was found that DESWS also shows pronounced analgesic properties at a dose of 30 mg/kg during the first and second hours of the experiment in the model of the limb’s thermal irritation «Hot Plate» in rats. After 120 minutes of experiment the studied activity didn’t change significantly and remained at the level 62.6%. The analgesic effect of DESWS was inferior to antinociceptive activity of ... |
format |
Article in Journal/Newspaper |
author |
L. Maloshtan K. Artemova O. Shatalova |
author_facet |
L. Maloshtan K. Artemova O. Shatalova |
author_sort |
L. Maloshtan |
title |
Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
title_short |
Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
title_full |
Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
title_fullStr |
Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
title_full_unstemmed |
Study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
title_sort |
study of analgesic and anti-inflammatory activity of dry extract from sakhalin willow shoots |
publisher |
The State Expert Center of the Ministry of Health of Ukraine |
publishDate |
2021 |
url |
https://doi.org/10.32352/0367-3057.4.21.09 https://doaj.org/article/52eb9a021f924e019a0a334fe3bf2fd5 |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_source |
Фармацевтичний журнал, Vol 4, Pp 103-110 (2021) |
op_relation |
https://pharmj.org.ua/index.php/journal/article/view/1242/1143 https://doaj.org/toc/0367-3057 https://doaj.org/toc/2617-9628 doi:10.32352/0367-3057.4.21.09 0367-3057 2617-9628 https://doaj.org/article/52eb9a021f924e019a0a334fe3bf2fd5 |
op_doi |
https://doi.org/10.32352/0367-3057.4.21.09 |
container_title |
Farmatsevtychnyi zhurnal |
container_issue |
4 |
container_start_page |
103 |
op_container_end_page |
110 |
_version_ |
1766181287656161280 |