Fatty acids linked to cardiovascular mortality are associated with risk factors
Background: Although saturated fatty acids (FAs) have been linked to cardiovascular mortality, it is not clear whether this outcome is attributable solely to their effects on low-density lipoprotein cholesterol (LDL-C) or whether other risk factors are also associated with FAs. The Western Alaskan N...
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2015
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Online Access: | https://doi.org/10.3402/ijch.v74.28055 https://doaj.org/article/52b11076cdad4576abfd933a79e45c93 |
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ftdoajarticles:oai:doaj.org/article:52b11076cdad4576abfd933a79e45c93 2023-05-15T15:16:07+02:00 Fatty acids linked to cardiovascular mortality are associated with risk factors Sven O. E. Ebbesson Venkata S. Voruganti Paul B. Higgins Richard R. Fabsitz Lars O. Ebbesson Sandra Laston William S. Harris John Kennish Benjamin D. Umans Hong Wang Richard B. Devereux Peter M. Okin Neil J. Weissman Jean W. MacCluer Jason G. Umans Barbara V. Howard 2015-08-01T00:00:00Z https://doi.org/10.3402/ijch.v74.28055 https://doaj.org/article/52b11076cdad4576abfd933a79e45c93 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/28055/pdf_24 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v74.28055 https://doaj.org/article/52b11076cdad4576abfd933a79e45c93 International Journal of Circumpolar Health, Vol 74, Iss 0, Pp 1-11 (2015) Alaska Natives cardiovascular risk factors dietary fat consumption fatty acids fish oil consumption Inuit saturated fatty acids Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.3402/ijch.v74.28055 2022-12-30T22:25:54Z Background: Although saturated fatty acids (FAs) have been linked to cardiovascular mortality, it is not clear whether this outcome is attributable solely to their effects on low-density lipoprotein cholesterol (LDL-C) or whether other risk factors are also associated with FAs. The Western Alaskan Native population, with its rapidly changing lifestyles, shift in diet from unsaturated to saturated fatty acids and dramatic increase in cardiovascular disease (CVD), presents an opportunity to elucidate any associations between specific FAs and known CVD risk factors. Objective: We tested the hypothesis that the specific FAs previously identified as related to CVD mortality are also associated with individual CVD risk factors. Methods: In this community-based, cross-sectional study, relative proportions of FAs in plasma and red blood cell membranes were compared with CVD risk factors in a sample of 758 men and women aged ≥35 years. Linear regression analyses were used to analyze relations between specific FAs and CVD risk factors (LDL-C, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, systolic blood pressure, diastolic blood pressure, heart rate, body mass index, fasting glucose and fasting insulin, 2-hour glucose and 2-hour insulin). Results: The specific saturated FAs previously identified as related to CVD mortality, the palmitic and myristic acids, were adversely associated with most CVD risk factors, whereas unsaturated linoleic acid (18:2n-6) and the marine n-3 FAs were not associated or were beneficially associated with CVD risk factors. Conclusions: The results suggest that CVD risk factors are more extensively affected by individual FAs than hitherto recognized, and that risk for CVD, MI and stroke can be reduced by reducing the intake of palmitate, myristic acid and simple carbohydrates and improved by greater intake of linoleic acid and marine n-3 FAs. Article in Journal/Newspaper Arctic Circumpolar Health International Journal of Circumpolar Health inuit Alaska Directory of Open Access Journals: DOAJ Articles Arctic International Journal of Circumpolar Health 74 1 28055 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Alaska Natives cardiovascular risk factors dietary fat consumption fatty acids fish oil consumption Inuit saturated fatty acids Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Alaska Natives cardiovascular risk factors dietary fat consumption fatty acids fish oil consumption Inuit saturated fatty acids Arctic medicine. Tropical medicine RC955-962 Sven O. E. Ebbesson Venkata S. Voruganti Paul B. Higgins Richard R. Fabsitz Lars O. Ebbesson Sandra Laston William S. Harris John Kennish Benjamin D. Umans Hong Wang Richard B. Devereux Peter M. Okin Neil J. Weissman Jean W. MacCluer Jason G. Umans Barbara V. Howard Fatty acids linked to cardiovascular mortality are associated with risk factors |
topic_facet |
Alaska Natives cardiovascular risk factors dietary fat consumption fatty acids fish oil consumption Inuit saturated fatty acids Arctic medicine. Tropical medicine RC955-962 |
description |
Background: Although saturated fatty acids (FAs) have been linked to cardiovascular mortality, it is not clear whether this outcome is attributable solely to their effects on low-density lipoprotein cholesterol (LDL-C) or whether other risk factors are also associated with FAs. The Western Alaskan Native population, with its rapidly changing lifestyles, shift in diet from unsaturated to saturated fatty acids and dramatic increase in cardiovascular disease (CVD), presents an opportunity to elucidate any associations between specific FAs and known CVD risk factors. Objective: We tested the hypothesis that the specific FAs previously identified as related to CVD mortality are also associated with individual CVD risk factors. Methods: In this community-based, cross-sectional study, relative proportions of FAs in plasma and red blood cell membranes were compared with CVD risk factors in a sample of 758 men and women aged ≥35 years. Linear regression analyses were used to analyze relations between specific FAs and CVD risk factors (LDL-C, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, systolic blood pressure, diastolic blood pressure, heart rate, body mass index, fasting glucose and fasting insulin, 2-hour glucose and 2-hour insulin). Results: The specific saturated FAs previously identified as related to CVD mortality, the palmitic and myristic acids, were adversely associated with most CVD risk factors, whereas unsaturated linoleic acid (18:2n-6) and the marine n-3 FAs were not associated or were beneficially associated with CVD risk factors. Conclusions: The results suggest that CVD risk factors are more extensively affected by individual FAs than hitherto recognized, and that risk for CVD, MI and stroke can be reduced by reducing the intake of palmitate, myristic acid and simple carbohydrates and improved by greater intake of linoleic acid and marine n-3 FAs. |
format |
Article in Journal/Newspaper |
author |
Sven O. E. Ebbesson Venkata S. Voruganti Paul B. Higgins Richard R. Fabsitz Lars O. Ebbesson Sandra Laston William S. Harris John Kennish Benjamin D. Umans Hong Wang Richard B. Devereux Peter M. Okin Neil J. Weissman Jean W. MacCluer Jason G. Umans Barbara V. Howard |
author_facet |
Sven O. E. Ebbesson Venkata S. Voruganti Paul B. Higgins Richard R. Fabsitz Lars O. Ebbesson Sandra Laston William S. Harris John Kennish Benjamin D. Umans Hong Wang Richard B. Devereux Peter M. Okin Neil J. Weissman Jean W. MacCluer Jason G. Umans Barbara V. Howard |
author_sort |
Sven O. E. Ebbesson |
title |
Fatty acids linked to cardiovascular mortality are associated with risk factors |
title_short |
Fatty acids linked to cardiovascular mortality are associated with risk factors |
title_full |
Fatty acids linked to cardiovascular mortality are associated with risk factors |
title_fullStr |
Fatty acids linked to cardiovascular mortality are associated with risk factors |
title_full_unstemmed |
Fatty acids linked to cardiovascular mortality are associated with risk factors |
title_sort |
fatty acids linked to cardiovascular mortality are associated with risk factors |
publisher |
Taylor & Francis Group |
publishDate |
2015 |
url |
https://doi.org/10.3402/ijch.v74.28055 https://doaj.org/article/52b11076cdad4576abfd933a79e45c93 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Alaska |
genre_facet |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Alaska |
op_source |
International Journal of Circumpolar Health, Vol 74, Iss 0, Pp 1-11 (2015) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/28055/pdf_24 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v74.28055 https://doaj.org/article/52b11076cdad4576abfd933a79e45c93 |
op_doi |
https://doi.org/10.3402/ijch.v74.28055 |
container_title |
International Journal of Circumpolar Health |
container_volume |
74 |
container_issue |
1 |
container_start_page |
28055 |
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1766346419531153408 |