Freqüência do parasitismo encefálico em camundongos experimentalmente inoculados com diferentes cepas de Trypanosoma cruzi

• Main Authors: C. F. S. Amaral, W. L. Tafuri, Z. Brener
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1975
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doaj.org/article/524d131085d549f4b70d71ddba26927b

Em grupos de camunáongos inoculados com as cepas FL, MR, Berenice e Y, a freqüência de parasitismo encefálico avaliada através do encontro de parasitas em cortes semi-seriados variou entre 1.6-22%, ao passo que nos animais inoculados com cepa PNM essa percentagem alcançou 20.5%. Os autores sugerem que esses resultados se devam a diferentes tropismos do parasita e discutem a importância do estudo de modelos experimentais para a investigação de lesões encefálicas causadas por T. cruzi. The frequency of encephalic parasitism in mice experimentally inoculated with different T. cruzi strains has been studied by examining semi-serial histological sections. Parasites have been found in 1.6-2.2% of the examined sections from animais inoculated with ctrains FL, MR, Y, Berenice, and in 20.5% of those inozulated with PNM strain. Those results have been suggested to be caused by different tropism of the parasite to the central nervous system. The importance of experimental models suitable to be used in the study of encephalic lesions in Chagas disease has been discussed.