The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats
Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose leve...
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Wolters Kluwer Medknow Publications
2017
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ftdoajarticles:oai:doaj.org/article:52214e5abb8241faa22973c3af5a4cc4 2023-05-15T15:08:56+02:00 The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats Suzanah Abdul Rahman Nur Amalina Ahmad Nadia Hanis Abdul Samat Syazana Zahri Afif Raihan Abdullah Kit-Lam Chan 2017-01-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.07.016 https://doaj.org/article/52214e5abb8241faa22973c3af5a4cc4 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116307924 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.07.016 https://doaj.org/article/52214e5abb8241faa22973c3af5a4cc4 Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 1, Pp 27-31 (2017) Eurycoma longifolia Oestrous cycle Testosterone Oestradiol Progesterone Ovaries Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.07.016 2022-12-31T14:05:33Z Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days. Vaginal smears were monitored daily within the duration and after withdrawal of the treatment before being sacrificed. The body weights of the females were recorded before and after the 5 days treatment. At the end of the experiments, blood samples were collected for determination of testosterone, oestradiol and progesterone levels. Ovaries were removed, weighed and examined for histomorphological changes. Results: The administration of E. longifolia standardized extract did not significantly alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the treatments. This was supported by normal testosterone, oestradiol and progesterone levels as well as normal morphology of the ovaries. Conclusions: The data obtained showed that E. longifolia standardized extract did not exhibit any toxic effect on reproductive activities of female rats suggesting potential use in the management of infertility. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 1 27 31 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Eurycoma longifolia Oestrous cycle Testosterone Oestradiol Progesterone Ovaries Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Eurycoma longifolia Oestrous cycle Testosterone Oestradiol Progesterone Ovaries Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Suzanah Abdul Rahman Nur Amalina Ahmad Nadia Hanis Abdul Samat Syazana Zahri Afif Raihan Abdullah Kit-Lam Chan The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
topic_facet |
Eurycoma longifolia Oestrous cycle Testosterone Oestradiol Progesterone Ovaries Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days. Vaginal smears were monitored daily within the duration and after withdrawal of the treatment before being sacrificed. The body weights of the females were recorded before and after the 5 days treatment. At the end of the experiments, blood samples were collected for determination of testosterone, oestradiol and progesterone levels. Ovaries were removed, weighed and examined for histomorphological changes. Results: The administration of E. longifolia standardized extract did not significantly alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the treatments. This was supported by normal testosterone, oestradiol and progesterone levels as well as normal morphology of the ovaries. Conclusions: The data obtained showed that E. longifolia standardized extract did not exhibit any toxic effect on reproductive activities of female rats suggesting potential use in the management of infertility. |
format |
Article in Journal/Newspaper |
author |
Suzanah Abdul Rahman Nur Amalina Ahmad Nadia Hanis Abdul Samat Syazana Zahri Afif Raihan Abdullah Kit-Lam Chan |
author_facet |
Suzanah Abdul Rahman Nur Amalina Ahmad Nadia Hanis Abdul Samat Syazana Zahri Afif Raihan Abdullah Kit-Lam Chan |
author_sort |
Suzanah Abdul Rahman |
title |
The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
title_short |
The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
title_full |
The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
title_fullStr |
The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
title_full_unstemmed |
The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
title_sort |
potential of standardized quassinoid-rich extract of eurycoma longifolia in the regulation of the oestrous cycle of rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2016.07.016 https://doaj.org/article/52214e5abb8241faa22973c3af5a4cc4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 1, Pp 27-31 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116307924 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.07.016 https://doaj.org/article/52214e5abb8241faa22973c3af5a4cc4 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.07.016 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
1 |
container_start_page |
27 |
op_container_end_page |
31 |
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1766340199252492288 |