Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers
ABSTRACT Background: The 2019 coronavirus (COVID-19) has precipitated a significant public health crisis. Our study aimed to evaluate the prevalence and risk factors associated with adverse reactions to the inactivated CoronaVac vaccine. Methods: The study involved voluntary health workers who recei...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Online Access: | https://doi.org/10.1590/0037-8682-0152-2023 https://doaj.org/article/51daca78f480491b9603a02478da98c7 |
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ftdoajarticles:oai:doaj.org/article:51daca78f480491b9603a02478da98c7 2023-10-29T02:34:36+01:00 Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers Beray Gelmez Taş İlknur Demir Muhammed Basanmay Güzin Zeren Öztürk Bestegül Çoruh Akyol Merve Hicret Tektaş Hacı Mustafa Özdemir 2023-09-01T00:00:00Z https://doi.org/10.1590/0037-8682-0152-2023 https://doaj.org/article/51daca78f480491b9603a02478da98c7 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100327&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0152-2023 https://doaj.org/article/51daca78f480491b9603a02478da98c7 Revista da Sociedade Brasileira de Medicina Tropical, Vol 56 (2023) COVID-19 vaccines Adverse reactions CoronaVac vaccine Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1590/0037-8682-0152-2023 2023-10-01T00:40:33Z ABSTRACT Background: The 2019 coronavirus (COVID-19) has precipitated a significant public health crisis. Our study aimed to evaluate the prevalence and risk factors associated with adverse reactions to the inactivated CoronaVac vaccine. Methods: The study involved voluntary health workers who received CoronaVac vaccine. We documented the sociodemographic information of 2,019 participants who volunteered for our study. Of these, 1,964 and 1,702 participants were interviewed by phone 1 month after the first and second dose, respectively, during which they were queried about any adverse reactions. Results: Within the first week after the first dose, adverse reactions were observed in 856 (43.3%) participants, with 133 (6.7%) experiencing them during the second week, and 96 (4.9%) people at the end of the first month. For the second dose, 276 individuals (16.2%) reported adverse reactions. The prevalence of both local and systemic adverse events ranged from 9.5-11.2% overall. Fatigue was the most common adverse reaction overall, while pain at the injection site was the most frequent local adverse reaction. Conclusions: The evaluation of both systemic and local side effects revealed no significant adverse reactions to the inactivated CoronaVac vaccine (Sinovac Life Sciences, Beijing, China). Our study found that the incidence of systemic and local adverse responses to the CoronaVac vaccination was lower than the rates reported in studies involving the recombinant adenovirus type-5, BNT162b1, and ChAdOx1nCoV-19 COVID-19 vaccines, all of which underwent the World Health Organization LULUC/PQ evaluation process. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Revista da Sociedade Brasileira de Medicina Tropical 56 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
COVID-19 vaccines Adverse reactions CoronaVac vaccine Arctic medicine. Tropical medicine RC955-962 |
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COVID-19 vaccines Adverse reactions CoronaVac vaccine Arctic medicine. Tropical medicine RC955-962 Beray Gelmez Taş İlknur Demir Muhammed Basanmay Güzin Zeren Öztürk Bestegül Çoruh Akyol Merve Hicret Tektaş Hacı Mustafa Özdemir Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers |
topic_facet |
COVID-19 vaccines Adverse reactions CoronaVac vaccine Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT Background: The 2019 coronavirus (COVID-19) has precipitated a significant public health crisis. Our study aimed to evaluate the prevalence and risk factors associated with adverse reactions to the inactivated CoronaVac vaccine. Methods: The study involved voluntary health workers who received CoronaVac vaccine. We documented the sociodemographic information of 2,019 participants who volunteered for our study. Of these, 1,964 and 1,702 participants were interviewed by phone 1 month after the first and second dose, respectively, during which they were queried about any adverse reactions. Results: Within the first week after the first dose, adverse reactions were observed in 856 (43.3%) participants, with 133 (6.7%) experiencing them during the second week, and 96 (4.9%) people at the end of the first month. For the second dose, 276 individuals (16.2%) reported adverse reactions. The prevalence of both local and systemic adverse events ranged from 9.5-11.2% overall. Fatigue was the most common adverse reaction overall, while pain at the injection site was the most frequent local adverse reaction. Conclusions: The evaluation of both systemic and local side effects revealed no significant adverse reactions to the inactivated CoronaVac vaccine (Sinovac Life Sciences, Beijing, China). Our study found that the incidence of systemic and local adverse responses to the CoronaVac vaccination was lower than the rates reported in studies involving the recombinant adenovirus type-5, BNT162b1, and ChAdOx1nCoV-19 COVID-19 vaccines, all of which underwent the World Health Organization LULUC/PQ evaluation process. |
format |
Article in Journal/Newspaper |
author |
Beray Gelmez Taş İlknur Demir Muhammed Basanmay Güzin Zeren Öztürk Bestegül Çoruh Akyol Merve Hicret Tektaş Hacı Mustafa Özdemir |
author_facet |
Beray Gelmez Taş İlknur Demir Muhammed Basanmay Güzin Zeren Öztürk Bestegül Çoruh Akyol Merve Hicret Tektaş Hacı Mustafa Özdemir |
author_sort |
Beray Gelmez Taş |
title |
Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers |
title_short |
Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers |
title_full |
Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers |
title_fullStr |
Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers |
title_full_unstemmed |
Frequency And Factors Associated With Adverse Reactions After Administration of Inactivated COVID-19 Vaccine Among Health Workers |
title_sort |
frequency and factors associated with adverse reactions after administration of inactivated covid-19 vaccine among health workers |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2023 |
url |
https://doi.org/10.1590/0037-8682-0152-2023 https://doaj.org/article/51daca78f480491b9603a02478da98c7 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 56 (2023) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100327&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0152-2023 https://doaj.org/article/51daca78f480491b9603a02478da98c7 |
op_doi |
https://doi.org/10.1590/0037-8682-0152-2023 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
56 |
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1781057256042790912 |