Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review.
Background Zika virus (ZIKV) has spread to five of the six World Health Organization (WHO) regions. Given the substantial number of asymptomatic infections and clinical presentations resembling those of other arboviruses, estimating the true burden of ZIKV infections is both challenging and essentia...
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ftdoajarticles:oai:doaj.org/article:51d2c5f5348f4cd28ba3f6756e08004e 2024-09-09T19:28:07+00:00 Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. Paola Mariela Saba Villarroel Rodolphe Hamel Nuttamonpat Gumpangseth Sakda Yainoy Phanit Koomhin Dorothée Missé Sineewanlaya Wichit 2024-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011842 https://doaj.org/article/51d2c5f5348f4cd28ba3f6756e08004e EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011842&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011842 https://doaj.org/article/51d2c5f5348f4cd28ba3f6756e08004e PLoS Neglected Tropical Diseases, Vol 18, Iss 4, p e0011842 (2024) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2024 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011842 2024-08-05T17:49:23Z Background Zika virus (ZIKV) has spread to five of the six World Health Organization (WHO) regions. Given the substantial number of asymptomatic infections and clinical presentations resembling those of other arboviruses, estimating the true burden of ZIKV infections is both challenging and essential. Therefore, we conducted a systematic review and meta-analysis of seroprevalence studies of ZIKV IgG in asymptomatic population to estimate its global impact and distribution. Methodology/principal findings We conducted extensive searches and compiled a collection of articles published from Jan/01/2000, to Jul/31/2023, from Embase, Pubmed, SciELO, and Scopus databases. The random effects model was used to pool prevalences, reported with their 95% confidence interval (CI), a tool to assess the risk of study bias in prevalence studies, and the I2 method for heterogeneity (PROSPERO registration No. CRD42023442227). Eighty-four studies from 49 countries/territories, with a diversity of study designs and serological tests were included. The global seroprevalence of ZIKV was 21.0% (95%CI 16.1%-26.4%). Evidence of IgG antibodies was identified in all WHO regions, except for Europe. Seroprevalence correlated with the epidemics in the Americas (39.9%, 95%CI:30.0-49.9), and in some Western Pacific countries (15.6%, 95%CI:8.2-24.9), as well as with recent and past circulation in Southeast Asia (22.8%, 95%CI:16.5-29.7), particularly in Thailand. Additionally, sustained low circulation was observed in Africa (8.4%, 95%CI:4.8-12.9), except for Gabon (43.7%), and Burkina Faso (22.8%). Although no autochthonous transmission was identified in the Eastern Mediterranean, a seroprevalence of 16.0% was recorded. Conclusions/significance The study highlights the high heterogeneity and gaps in the distribution of seroprevalence. The implementation of standardized protocols and the development of tests with high specificity are essential for ensuring a valid comparison between studies. Equally crucial are vector surveillance and control ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific PLOS Neglected Tropical Diseases 18 4 e0011842 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Paola Mariela Saba Villarroel Rodolphe Hamel Nuttamonpat Gumpangseth Sakda Yainoy Phanit Koomhin Dorothée Missé Sineewanlaya Wichit Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Zika virus (ZIKV) has spread to five of the six World Health Organization (WHO) regions. Given the substantial number of asymptomatic infections and clinical presentations resembling those of other arboviruses, estimating the true burden of ZIKV infections is both challenging and essential. Therefore, we conducted a systematic review and meta-analysis of seroprevalence studies of ZIKV IgG in asymptomatic population to estimate its global impact and distribution. Methodology/principal findings We conducted extensive searches and compiled a collection of articles published from Jan/01/2000, to Jul/31/2023, from Embase, Pubmed, SciELO, and Scopus databases. The random effects model was used to pool prevalences, reported with their 95% confidence interval (CI), a tool to assess the risk of study bias in prevalence studies, and the I2 method for heterogeneity (PROSPERO registration No. CRD42023442227). Eighty-four studies from 49 countries/territories, with a diversity of study designs and serological tests were included. The global seroprevalence of ZIKV was 21.0% (95%CI 16.1%-26.4%). Evidence of IgG antibodies was identified in all WHO regions, except for Europe. Seroprevalence correlated with the epidemics in the Americas (39.9%, 95%CI:30.0-49.9), and in some Western Pacific countries (15.6%, 95%CI:8.2-24.9), as well as with recent and past circulation in Southeast Asia (22.8%, 95%CI:16.5-29.7), particularly in Thailand. Additionally, sustained low circulation was observed in Africa (8.4%, 95%CI:4.8-12.9), except for Gabon (43.7%), and Burkina Faso (22.8%). Although no autochthonous transmission was identified in the Eastern Mediterranean, a seroprevalence of 16.0% was recorded. Conclusions/significance The study highlights the high heterogeneity and gaps in the distribution of seroprevalence. The implementation of standardized protocols and the development of tests with high specificity are essential for ensuring a valid comparison between studies. Equally crucial are vector surveillance and control ... |
format |
Article in Journal/Newspaper |
author |
Paola Mariela Saba Villarroel Rodolphe Hamel Nuttamonpat Gumpangseth Sakda Yainoy Phanit Koomhin Dorothée Missé Sineewanlaya Wichit |
author_facet |
Paola Mariela Saba Villarroel Rodolphe Hamel Nuttamonpat Gumpangseth Sakda Yainoy Phanit Koomhin Dorothée Missé Sineewanlaya Wichit |
author_sort |
Paola Mariela Saba Villarroel |
title |
Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. |
title_short |
Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. |
title_full |
Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. |
title_fullStr |
Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. |
title_full_unstemmed |
Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review. |
title_sort |
global seroprevalence of zika virus in asymptomatic individuals: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2024 |
url |
https://doi.org/10.1371/journal.pntd.0011842 https://doaj.org/article/51d2c5f5348f4cd28ba3f6756e08004e |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 18, Iss 4, p e0011842 (2024) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011842&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011842 https://doaj.org/article/51d2c5f5348f4cd28ba3f6756e08004e |
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https://doi.org/10.1371/journal.pntd.0011842 |
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PLOS Neglected Tropical Diseases |
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18 |
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4 |
container_start_page |
e0011842 |
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1809897396213121024 |