Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil
An open trial to evaluate the azithromycin efficacy in cutaneous leishmaniasis patients was carried out in Manaus (AM), where Leishmania (Viannia) guyanensis is the main etiologic agent. Forty-one patients with skin lesions of less than 12 weeks duration, without specific treatment for the last thre...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
2007
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ftdoajarticles:oai:doaj.org/article:51647e2544a142e493304f4b5e1fd2ac 2024-09-09T19:28:25+00:00 Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil Alan César Teixeira Marcilene Gomes Paes Jorge de Oliveira Guerra Aluízio Prata Mario León Silva-Vergara 2007-08-01T00:00:00Z https://doi.org/10.1590/S0036-46652007000400008 https://doaj.org/article/51647e2544a142e493304f4b5e1fd2ac EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000400008 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652007000400008 0036-4665 1678-9946 https://doaj.org/article/51647e2544a142e493304f4b5e1fd2ac Revista do Instituto de Medicina Tropical de São Paulo, Vol 49, Iss 4, Pp 235-238 (2007) Azithromycin Cutaneous leishmaniasis Antimony Leishmania (Viannia) guyanensis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1590/S0036-46652007000400008 2024-08-05T17:49:30Z An open trial to evaluate the azithromycin efficacy in cutaneous leishmaniasis patients was carried out in Manaus (AM), where Leishmania (Viannia) guyanensis is the main etiologic agent. Forty-one patients with skin lesions of less than 12 weeks duration, without specific treatment for the last three months and a positive imprint to Leishmania sp. were included. From these, 31 (75.6%) were male with median age of 30.2. All of them received a daily-single oral dose of 500 mg of azithromycin for ten days. At 25th day, 16 (39%) presented therapeutic failure and received intramuscular pentavalent antimonial, four were considered lost, 21, that had improved or were inaltered received another ten-day series of azithromycin and were monthly followed, but nine (21.9%) of them presented a poor clinical response and switched to intramuscular pentavalent antimonial on day 55. Of the 12 remaining cases evaluated on day 55, despite of clinical improvement, three asked for antimony therapy and 9 (21.9%) continued the follow-up but, only three were cured on 55th, 85th and 115th days, and six did not come back for final evaluation. The intention-treatment overall response rate was 22% and whole cure was seen in three (7.3%) of cases. Thus, azithromycin showed a low efficacy to treat cutaneous leishmaniasis in Manaus. Para avaliar a eficácia da azitromicina na leishmaniose cutânea, foi realizado ensaio clínico em Manaus, Amazonas, onde o agente etiológico predominante é a Leishmania (Viannia) guyanensis. Incluídos 41 pacientes com lesões de menos de 12 semanas, sem história de tratamento específico nos últimos três meses e com esfregaço positivo para Leishmania sp. Destes, 31 (75,6%) eram masculinos, idade média 30,2 anos. Todos receberam azitromicina 500 mg em dose única oral, diária, por 10 dias. No dia 25º, 16 (39%) pioraram e receberam antimonial pentavalente via intramuscular por 20 dias e, 21 (61%) que apresentaram melhora da lesão ou esta permanecia inalterada no 25º dia, receberam outro ciclo de 10 dias de azitromicina e ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 49 4 235 238 |
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English |
topic |
Azithromycin Cutaneous leishmaniasis Antimony Leishmania (Viannia) guyanensis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Azithromycin Cutaneous leishmaniasis Antimony Leishmania (Viannia) guyanensis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Alan César Teixeira Marcilene Gomes Paes Jorge de Oliveira Guerra Aluízio Prata Mario León Silva-Vergara Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil |
topic_facet |
Azithromycin Cutaneous leishmaniasis Antimony Leishmania (Viannia) guyanensis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
An open trial to evaluate the azithromycin efficacy in cutaneous leishmaniasis patients was carried out in Manaus (AM), where Leishmania (Viannia) guyanensis is the main etiologic agent. Forty-one patients with skin lesions of less than 12 weeks duration, without specific treatment for the last three months and a positive imprint to Leishmania sp. were included. From these, 31 (75.6%) were male with median age of 30.2. All of them received a daily-single oral dose of 500 mg of azithromycin for ten days. At 25th day, 16 (39%) presented therapeutic failure and received intramuscular pentavalent antimonial, four were considered lost, 21, that had improved or were inaltered received another ten-day series of azithromycin and were monthly followed, but nine (21.9%) of them presented a poor clinical response and switched to intramuscular pentavalent antimonial on day 55. Of the 12 remaining cases evaluated on day 55, despite of clinical improvement, three asked for antimony therapy and 9 (21.9%) continued the follow-up but, only three were cured on 55th, 85th and 115th days, and six did not come back for final evaluation. The intention-treatment overall response rate was 22% and whole cure was seen in three (7.3%) of cases. Thus, azithromycin showed a low efficacy to treat cutaneous leishmaniasis in Manaus. Para avaliar a eficácia da azitromicina na leishmaniose cutânea, foi realizado ensaio clínico em Manaus, Amazonas, onde o agente etiológico predominante é a Leishmania (Viannia) guyanensis. Incluídos 41 pacientes com lesões de menos de 12 semanas, sem história de tratamento específico nos últimos três meses e com esfregaço positivo para Leishmania sp. Destes, 31 (75,6%) eram masculinos, idade média 30,2 anos. Todos receberam azitromicina 500 mg em dose única oral, diária, por 10 dias. No dia 25º, 16 (39%) pioraram e receberam antimonial pentavalente via intramuscular por 20 dias e, 21 (61%) que apresentaram melhora da lesão ou esta permanecia inalterada no 25º dia, receberam outro ciclo de 10 dias de azitromicina e ... |
format |
Article in Journal/Newspaper |
author |
Alan César Teixeira Marcilene Gomes Paes Jorge de Oliveira Guerra Aluízio Prata Mario León Silva-Vergara |
author_facet |
Alan César Teixeira Marcilene Gomes Paes Jorge de Oliveira Guerra Aluízio Prata Mario León Silva-Vergara |
author_sort |
Alan César Teixeira |
title |
Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil |
title_short |
Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil |
title_full |
Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil |
title_fullStr |
Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil |
title_full_unstemmed |
Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Azitromicina para tratamento de leishmaniose cutânea em Manaus, AM, Brasil |
title_sort |
low efficacy of azithromycin to treat cutaneous leishmaniasis in manaus, am, brazil azitromicina para tratamento de leishmaniose cutânea em manaus, am, brasil |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2007 |
url |
https://doi.org/10.1590/S0036-46652007000400008 https://doaj.org/article/51647e2544a142e493304f4b5e1fd2ac |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 49, Iss 4, Pp 235-238 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000400008 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652007000400008 0036-4665 1678-9946 https://doaj.org/article/51647e2544a142e493304f4b5e1fd2ac |
op_doi |
https://doi.org/10.1590/S0036-46652007000400008 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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49 |
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