The impact of ABO and RhD blood types on Babesia microti infection.
Background Babesiosis is an emerging infectious disease caused by intraerythrocytic Babesia parasites that can cause severe disease and death. While blood type is known to affect the mortality of Plasmodium falciparum malaria patients, associations between red blood cell (RBC) antigens and Babesia m...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0011060 https://doaj.org/article/50776631fdb445cebf303ad81cf8ca6e |
id |
ftdoajarticles:oai:doaj.org/article:50776631fdb445cebf303ad81cf8ca6e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:50776631fdb445cebf303ad81cf8ca6e 2023-05-15T15:17:39+02:00 The impact of ABO and RhD blood types on Babesia microti infection. Ryan Philip Jajosky Jane O'Bryan Anne Spichler-Moffarah Philip G Jajosky Peter J Krause Laura Tonnetti 2023-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011060 https://doaj.org/article/50776631fdb445cebf303ad81cf8ca6e EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011060 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011060 https://doaj.org/article/50776631fdb445cebf303ad81cf8ca6e PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011060 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011060 2023-03-05T01:33:15Z Background Babesiosis is an emerging infectious disease caused by intraerythrocytic Babesia parasites that can cause severe disease and death. While blood type is known to affect the mortality of Plasmodium falciparum malaria patients, associations between red blood cell (RBC) antigens and Babesia microti infection and disease severity are lacking. Methods We evaluated RhD and ABO blood types of Babesia-infected (18S rRNA reactive) blood donors in 10 endemic states in the Northeastern and northern Midwestern United States. We also assessed possible associations between RhD and ABO blood types and disease severity among hospitalized babesiosis patients in Connecticut. Results A total of 768 Babesia-infected blood donors were analyzed, of which 750 (97.7%) had detectable B. microti-specific antibodies. B. microti-infected blood donors were more likely to be RhD- (OR of 1.22, p-value 0.024) than RhD+ donors. Hospitalized RhD- babesiosis patients were more likely than RhD+ patients to have high peak parasitemia (p-value 0.017), which is a marker for disease severity. No differences in RhD+ blood type were noted between residents of the Northeast (OR of 0.82, p-value 0.033) and the Midwest (OR of 0.74, p-value 0.23). Overall, ABO blood type was not associated with blood donor B. microti infection, however, B. microti-infected donors in Maine and New Jersey were more likely to be blood type B compared to non-type B (OR 2.49 [p = 0.008] and 2.07 [p = 0.009], respectively), while infected donors from Pennsylvania were less likely to be type B compared to non-type B (OR 0.32 [p = 0.02]). Conclusions People expressing RhD antigen may have a decreased risk of B. microti infection and babesiosis severity. The association of B antigen with B. microti infection is less clear because the antigen appeared to be less prevalent in infected Pennsylvania blood donors but more prevalent in Maine and New Jersey infected donors. Future studies should quantify associations between B. microti genotypes, RBC antigens, and the frequency ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 1 e0011060 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ryan Philip Jajosky Jane O'Bryan Anne Spichler-Moffarah Philip G Jajosky Peter J Krause Laura Tonnetti The impact of ABO and RhD blood types on Babesia microti infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Babesiosis is an emerging infectious disease caused by intraerythrocytic Babesia parasites that can cause severe disease and death. While blood type is known to affect the mortality of Plasmodium falciparum malaria patients, associations between red blood cell (RBC) antigens and Babesia microti infection and disease severity are lacking. Methods We evaluated RhD and ABO blood types of Babesia-infected (18S rRNA reactive) blood donors in 10 endemic states in the Northeastern and northern Midwestern United States. We also assessed possible associations between RhD and ABO blood types and disease severity among hospitalized babesiosis patients in Connecticut. Results A total of 768 Babesia-infected blood donors were analyzed, of which 750 (97.7%) had detectable B. microti-specific antibodies. B. microti-infected blood donors were more likely to be RhD- (OR of 1.22, p-value 0.024) than RhD+ donors. Hospitalized RhD- babesiosis patients were more likely than RhD+ patients to have high peak parasitemia (p-value 0.017), which is a marker for disease severity. No differences in RhD+ blood type were noted between residents of the Northeast (OR of 0.82, p-value 0.033) and the Midwest (OR of 0.74, p-value 0.23). Overall, ABO blood type was not associated with blood donor B. microti infection, however, B. microti-infected donors in Maine and New Jersey were more likely to be blood type B compared to non-type B (OR 2.49 [p = 0.008] and 2.07 [p = 0.009], respectively), while infected donors from Pennsylvania were less likely to be type B compared to non-type B (OR 0.32 [p = 0.02]). Conclusions People expressing RhD antigen may have a decreased risk of B. microti infection and babesiosis severity. The association of B antigen with B. microti infection is less clear because the antigen appeared to be less prevalent in infected Pennsylvania blood donors but more prevalent in Maine and New Jersey infected donors. Future studies should quantify associations between B. microti genotypes, RBC antigens, and the frequency ... |
format |
Article in Journal/Newspaper |
author |
Ryan Philip Jajosky Jane O'Bryan Anne Spichler-Moffarah Philip G Jajosky Peter J Krause Laura Tonnetti |
author_facet |
Ryan Philip Jajosky Jane O'Bryan Anne Spichler-Moffarah Philip G Jajosky Peter J Krause Laura Tonnetti |
author_sort |
Ryan Philip Jajosky |
title |
The impact of ABO and RhD blood types on Babesia microti infection. |
title_short |
The impact of ABO and RhD blood types on Babesia microti infection. |
title_full |
The impact of ABO and RhD blood types on Babesia microti infection. |
title_fullStr |
The impact of ABO and RhD blood types on Babesia microti infection. |
title_full_unstemmed |
The impact of ABO and RhD blood types on Babesia microti infection. |
title_sort |
impact of abo and rhd blood types on babesia microti infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011060 https://doaj.org/article/50776631fdb445cebf303ad81cf8ca6e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011060 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011060 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011060 https://doaj.org/article/50776631fdb445cebf303ad81cf8ca6e |
op_doi |
https://doi.org/10.1371/journal.pntd.0011060 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
1 |
container_start_page |
e0011060 |
_version_ |
1766347904061014016 |