Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia
Introduction. Metabolic bone disease of premature infants is a rare complication characterized by a lower mineral content in bone tissue. Objective. To establish the incidence of metabolic bone disease in premature infants and to determine associated risk factors. Materials and method. We conducted...
Published in: | Biomédica |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English Spanish |
Published: |
Instituto Nacional de Salud
2024
|
Subjects: | |
Online Access: | https://doi.org/10.7705/biomedica.6926 https://doaj.org/article/5051962949764e05bbf9864efa73e9c2 |
id |
ftdoajarticles:oai:doaj.org/article:5051962949764e05bbf9864efa73e9c2 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5051962949764e05bbf9864efa73e9c2 2024-09-09T19:27:28+00:00 Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia Erika Ruiz Diego Ernesto Piamonte Deisy Tatiana Gómez Luis Alfonso Díaz Luis Alfonso Pérez 2024-03-01T00:00:00Z https://doi.org/10.7705/biomedica.6926 https://doaj.org/article/5051962949764e05bbf9864efa73e9c2 EN ES eng spa Instituto Nacional de Salud https://revistabiomedica.org/index.php/biomedica/article/view/6926 https://doaj.org/toc/0120-4157 https://doaj.org/toc/2590-7379 0120-4157 2590-7379 doi:10.7705/biomedica.6926 https://doaj.org/article/5051962949764e05bbf9864efa73e9c2 Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss 1, Pp 35-44 (2024) bone diseases metabolic infant premature alkaline phosphatase phosphorus vitamin d Medicine R Arctic medicine. Tropical medicine RC955-962 article 2024 ftdoajarticles https://doi.org/10.7705/biomedica.6926 2024-08-05T17:49:33Z Introduction. Metabolic bone disease of premature infants is a rare complication characterized by a lower mineral content in bone tissue. Objective. To establish the incidence of metabolic bone disease in premature infants and to determine associated risk factors. Materials and method. We conducted a descriptive prospective cohort study for one year in all newborns under 32 gestational weeks, or 1,500 g, at the Hospital Universitario de Santander to determine the incidence of metabolic bone disease. We collected demographic data and prenatal histories of the selected patients, and later, we measured serum alkaline phosphatase and serum phosphorus at the third week of birth, having as reference values for diagnosis less than 5.6 mg/dl for the first one and more than 500 UI/L for the second one. We applied statistical tools for data analysis, such as average proportions, dispersion, distribution and association measures, and binomial regression. Results. From a total of 58 patients, 7 had a diagnosis of metabolic bone disease, with an incidence of 12%. The weight was reported as an independent variable for the development of the disease, being significant in children under 1,160 g, as well as prolonged parenteral nutrition for more than 24 days. When performing the multivariate analysis, low weight and short time of parenteral nutrition appeared as risk factors; in the same way, maternal age below 22 years is associated with a higher relative risk, even more than a newborn weight inferior to 1,160 g. Conclusion. Establishing an early intervention in patients with metabolic bone disease enhancing risk factors, such as low weight and prolonged parenteral nutrition, is critical to prevent severe complications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 44 1 35 44 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
bone diseases metabolic infant premature alkaline phosphatase phosphorus vitamin d Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
bone diseases metabolic infant premature alkaline phosphatase phosphorus vitamin d Medicine R Arctic medicine. Tropical medicine RC955-962 Erika Ruiz Diego Ernesto Piamonte Deisy Tatiana Gómez Luis Alfonso Díaz Luis Alfonso Pérez Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia |
topic_facet |
bone diseases metabolic infant premature alkaline phosphatase phosphorus vitamin d Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction. Metabolic bone disease of premature infants is a rare complication characterized by a lower mineral content in bone tissue. Objective. To establish the incidence of metabolic bone disease in premature infants and to determine associated risk factors. Materials and method. We conducted a descriptive prospective cohort study for one year in all newborns under 32 gestational weeks, or 1,500 g, at the Hospital Universitario de Santander to determine the incidence of metabolic bone disease. We collected demographic data and prenatal histories of the selected patients, and later, we measured serum alkaline phosphatase and serum phosphorus at the third week of birth, having as reference values for diagnosis less than 5.6 mg/dl for the first one and more than 500 UI/L for the second one. We applied statistical tools for data analysis, such as average proportions, dispersion, distribution and association measures, and binomial regression. Results. From a total of 58 patients, 7 had a diagnosis of metabolic bone disease, with an incidence of 12%. The weight was reported as an independent variable for the development of the disease, being significant in children under 1,160 g, as well as prolonged parenteral nutrition for more than 24 days. When performing the multivariate analysis, low weight and short time of parenteral nutrition appeared as risk factors; in the same way, maternal age below 22 years is associated with a higher relative risk, even more than a newborn weight inferior to 1,160 g. Conclusion. Establishing an early intervention in patients with metabolic bone disease enhancing risk factors, such as low weight and prolonged parenteral nutrition, is critical to prevent severe complications. |
format |
Article in Journal/Newspaper |
author |
Erika Ruiz Diego Ernesto Piamonte Deisy Tatiana Gómez Luis Alfonso Díaz Luis Alfonso Pérez |
author_facet |
Erika Ruiz Diego Ernesto Piamonte Deisy Tatiana Gómez Luis Alfonso Díaz Luis Alfonso Pérez |
author_sort |
Erika Ruiz |
title |
Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia |
title_short |
Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia |
title_full |
Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia |
title_fullStr |
Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia |
title_full_unstemmed |
Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia |
title_sort |
incidence of metabolic bone disease in neonates under 32 gestational weeks at the hospital universitario de santander in colombia |
publisher |
Instituto Nacional de Salud |
publishDate |
2024 |
url |
https://doi.org/10.7705/biomedica.6926 https://doaj.org/article/5051962949764e05bbf9864efa73e9c2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss 1, Pp 35-44 (2024) |
op_relation |
https://revistabiomedica.org/index.php/biomedica/article/view/6926 https://doaj.org/toc/0120-4157 https://doaj.org/toc/2590-7379 0120-4157 2590-7379 doi:10.7705/biomedica.6926 https://doaj.org/article/5051962949764e05bbf9864efa73e9c2 |
op_doi |
https://doi.org/10.7705/biomedica.6926 |
container_title |
Biomédica |
container_volume |
44 |
container_issue |
1 |
container_start_page |
35 |
op_container_end_page |
44 |
_version_ |
1809896900000743424 |