Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients.
Backgrounds Approximately, half of the population in the world including tropical and sub-tropical climates region is at risk of dengue. Being an endemic country, Bangladesh has experienced the largest dengue epidemic in 2019. The present study aimed at evaluating the clinical and laboratory profile...
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ftdoajarticles:oai:doaj.org/article:5050741b9f904378bae0bdc4cbc4a1b0 2023-05-15T15:15:40+02:00 Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. Abdur Rafi Ashrafun Nahar Mousumi Reejvi Ahmed Rezwanul Haque Chowdhury Abdul Wadood Golam Hossain 2020-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008567 https://doaj.org/article/5050741b9f904378bae0bdc4cbc4a1b0 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008567 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008567 https://doaj.org/article/5050741b9f904378bae0bdc4cbc4a1b0 PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008567 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008567 2022-12-31T09:00:55Z Backgrounds Approximately, half of the population in the world including tropical and sub-tropical climates region is at risk of dengue. Being an endemic country, Bangladesh has experienced the largest dengue epidemic in 2019. The present study aimed at evaluating the clinical and laboratory profile of dengue patients in northern Bangladesh during the epidemic. Methods This cross-sectional study included 319 serologically confirmed dengue patients admitted in Shaheed Ziaur Rahman Medical College Hospital in Bogra district. It is one of the main tertiary care hospitals in northern Bangladesh. Data were collected from July to September 2019. Patients' clinical and laboratory data were extracted from clinical records. Patients were classified into two classes according to the WHO 2009 dengue classification such as (i) non-severe dengue and (ii) severe dengue. Chi-square test and independent t-test were used in this study. Results Of the 319 patients, 94.1% had non-severe dengue and the remaining 5.9% had severe dengue (severe plasma leakage 68.4%, severe organ involvement 68.4%, and severe clinical bleeding 10.5%). Most of the patients were suffering from primary dengue infection. The most common clinical presentation was fever followed by headache and myalgia. Vomiting and abdominal pain were the most prevalent warning signs. The common hematological findings on admission were leukopenia (63.3%), thrombocytopenia (30.4%) and increased hematocrit (26.6%). Raised serum ALT or AST was observed in 14.1% cases whereas raised serum creatinine was observed in 6.6% cases. Signs of plasma leakage (pleural effusion, respiratory distress, and ascites, rise of hematocrit >20% during hospital stay) and hepatic or renal involvement (serum ALT >42UI/L or serum creatinine >1.2 mg/dL) on admission were mostly associated with severe dengue. Conclusion The study provides clinical evidence on presentation as well as hematological and biochemical profile of dengue patients in northern Bangladesh that should be implicated in ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 10 e0008567 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Abdur Rafi Ashrafun Nahar Mousumi Reejvi Ahmed Rezwanul Haque Chowdhury Abdul Wadood Golam Hossain Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Backgrounds Approximately, half of the population in the world including tropical and sub-tropical climates region is at risk of dengue. Being an endemic country, Bangladesh has experienced the largest dengue epidemic in 2019. The present study aimed at evaluating the clinical and laboratory profile of dengue patients in northern Bangladesh during the epidemic. Methods This cross-sectional study included 319 serologically confirmed dengue patients admitted in Shaheed Ziaur Rahman Medical College Hospital in Bogra district. It is one of the main tertiary care hospitals in northern Bangladesh. Data were collected from July to September 2019. Patients' clinical and laboratory data were extracted from clinical records. Patients were classified into two classes according to the WHO 2009 dengue classification such as (i) non-severe dengue and (ii) severe dengue. Chi-square test and independent t-test were used in this study. Results Of the 319 patients, 94.1% had non-severe dengue and the remaining 5.9% had severe dengue (severe plasma leakage 68.4%, severe organ involvement 68.4%, and severe clinical bleeding 10.5%). Most of the patients were suffering from primary dengue infection. The most common clinical presentation was fever followed by headache and myalgia. Vomiting and abdominal pain were the most prevalent warning signs. The common hematological findings on admission were leukopenia (63.3%), thrombocytopenia (30.4%) and increased hematocrit (26.6%). Raised serum ALT or AST was observed in 14.1% cases whereas raised serum creatinine was observed in 6.6% cases. Signs of plasma leakage (pleural effusion, respiratory distress, and ascites, rise of hematocrit >20% during hospital stay) and hepatic or renal involvement (serum ALT >42UI/L or serum creatinine >1.2 mg/dL) on admission were mostly associated with severe dengue. Conclusion The study provides clinical evidence on presentation as well as hematological and biochemical profile of dengue patients in northern Bangladesh that should be implicated in ... |
format |
Article in Journal/Newspaper |
author |
Abdur Rafi Ashrafun Nahar Mousumi Reejvi Ahmed Rezwanul Haque Chowdhury Abdul Wadood Golam Hossain |
author_facet |
Abdur Rafi Ashrafun Nahar Mousumi Reejvi Ahmed Rezwanul Haque Chowdhury Abdul Wadood Golam Hossain |
author_sort |
Abdur Rafi |
title |
Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. |
title_short |
Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. |
title_full |
Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. |
title_fullStr |
Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. |
title_full_unstemmed |
Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. |
title_sort |
dengue epidemic in a non-endemic zone of bangladesh: clinical and laboratory profiles of patients. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008567 https://doaj.org/article/5050741b9f904378bae0bdc4cbc4a1b0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008567 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008567 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008567 https://doaj.org/article/5050741b9f904378bae0bdc4cbc4a1b0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008567 |
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PLOS Neglected Tropical Diseases |
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14 |
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10 |
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e0008567 |
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