Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Braz...
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Online Access: | https://doi.org/10.1590/0037-8682-0225-2018 https://doaj.org/article/5049e292d00a4825adf8d3933a42d3c8 |
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ftdoajarticles:oai:doaj.org/article:5049e292d00a4825adf8d3933a42d3c8 2023-05-15T15:01:22+02:00 Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene Francesca Chapadense Ricardo Luiz Dantas Machado Ana Maria Revorêdo da Silva Ventura André Áreas Renato Beilner Machado Giselle Rachid Viana Mariano Gustavo Zalis Ana Maria de Castro Pedro Cravo 2019-02-01T00:00:00Z https://doi.org/10.1590/0037-8682-0225-2018 https://doaj.org/article/5049e292d00a4825adf8d3933a42d3c8 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100614&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0225-2018 https://doaj.org/article/5049e292d00a4825adf8d3933a42d3c8 Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) Malaria Plasmodium falciparum Artemisinin Resistance Kelch 13 Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1590/0037-8682-0225-2018 2022-12-31T03:21:28Z Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. CONCLUSIONS: Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 52 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium falciparum Artemisinin Resistance Kelch 13 Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Malaria Plasmodium falciparum Artemisinin Resistance Kelch 13 Arctic medicine. Tropical medicine RC955-962 Francesca Chapadense Ricardo Luiz Dantas Machado Ana Maria Revorêdo da Silva Ventura André Áreas Renato Beilner Machado Giselle Rachid Viana Mariano Gustavo Zalis Ana Maria de Castro Pedro Cravo Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
topic_facet |
Malaria Plasmodium falciparum Artemisinin Resistance Kelch 13 Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. CONCLUSIONS: Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy. |
format |
Article in Journal/Newspaper |
author |
Francesca Chapadense Ricardo Luiz Dantas Machado Ana Maria Revorêdo da Silva Ventura André Áreas Renato Beilner Machado Giselle Rachid Viana Mariano Gustavo Zalis Ana Maria de Castro Pedro Cravo |
author_facet |
Francesca Chapadense Ricardo Luiz Dantas Machado Ana Maria Revorêdo da Silva Ventura André Áreas Renato Beilner Machado Giselle Rachid Viana Mariano Gustavo Zalis Ana Maria de Castro Pedro Cravo |
author_sort |
Francesca Chapadense |
title |
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
title_short |
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
title_full |
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
title_fullStr |
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
title_full_unstemmed |
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
title_sort |
plasmodium falciparum malarial parasites from brazil lack artemisinin resistance-associated mutations in the kelch13 gene |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2019 |
url |
https://doi.org/10.1590/0037-8682-0225-2018 https://doaj.org/article/5049e292d00a4825adf8d3933a42d3c8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100614&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0225-2018 https://doaj.org/article/5049e292d00a4825adf8d3933a42d3c8 |
op_doi |
https://doi.org/10.1590/0037-8682-0225-2018 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
52 |
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