Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
Abstract Background The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective...
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ftdoajarticles:oai:doaj.org/article:50169d56ac0342a09761efe539e3bc1d 2023-05-15T15:14:34+02:00 Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity von Seidlein Lorenz Drakeley Chris J Sutherland Colin J Price Ric N Stepniewska Kasia Nosten Francois White Nicholas J 2008-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-249 https://doaj.org/article/50169d56ac0342a09761efe539e3bc1d EN eng BMC http://www.malariajournal.com/content/7/1/249 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-249 1475-2875 https://doaj.org/article/50169d56ac0342a09761efe539e3bc1d Malaria Journal, Vol 7, Iss 1, p 249 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-249 2023-01-08T01:37:56Z Abstract Background The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine-pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 von Seidlein Lorenz Drakeley Chris J Sutherland Colin J Price Ric N Stepniewska Kasia Nosten Francois White Nicholas J Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. Methods Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. Results Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine-pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. Conclusion This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places. |
format |
Article in Journal/Newspaper |
author |
von Seidlein Lorenz Drakeley Chris J Sutherland Colin J Price Ric N Stepniewska Kasia Nosten Francois White Nicholas J |
author_facet |
von Seidlein Lorenz Drakeley Chris J Sutherland Colin J Price Ric N Stepniewska Kasia Nosten Francois White Nicholas J |
author_sort |
von Seidlein Lorenz |
title |
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
title_short |
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
title_full |
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
title_fullStr |
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
title_full_unstemmed |
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
title_sort |
plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-249 https://doaj.org/article/50169d56ac0342a09761efe539e3bc1d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 249 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/249 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-249 1475-2875 https://doaj.org/article/50169d56ac0342a09761efe539e3bc1d |
op_doi |
https://doi.org/10.1186/1475-2875-7-249 |
container_title |
Malaria Journal |
container_volume |
7 |
container_issue |
1 |
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1766345008455090176 |