Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review.
Background Cholera is an acute, diarrheal disease caused by Vibrio cholerae O1 or 139 that is associated with a high global burden. Methods We analyzed the estimated duration of immunity following cholera infection from available published studies. We searched PubMed and Web of Science for studies o...
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ftdoajarticles:oai:doaj.org/article:500a662489354eeba9e469e2c1e9e71b 2023-05-15T15:07:30+02:00 Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. Tiffany Leung Laura Matrajt 2021-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009383 https://doaj.org/article/500a662489354eeba9e469e2c1e9e71b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009383 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009383 https://doaj.org/article/500a662489354eeba9e469e2c1e9e71b PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009383 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009383 2022-12-31T05:07:34Z Background Cholera is an acute, diarrheal disease caused by Vibrio cholerae O1 or 139 that is associated with a high global burden. Methods We analyzed the estimated duration of immunity following cholera infection from available published studies. We searched PubMed and Web of Science for studies of the long-term immunity following cholera infection. We identified 22 eligible studies and categorized them as either observational, challenge, or serological. Results We found strong evidence of protection at 3 years after infection in observational and challenge studies. However, serological studies show that elevated humoral markers of potential correlates of protection returned to baseline within 1 year. Additionally, a subclinical cholera infection may confer lower protection than a clinical one, as suggested by 3 studies that found that, albeit with small sample sizes, most participants with a subclinical infection from an initial challenge with cholera had a symptomatic infection when rechallenged with a homologous biotype. Conclusions This review underscores the need to elucidate potential differences in the protection provided by clinical and subclinical cholera infections. Further, more studies are warranted to bridge the gap between the correlates of protection and cholera immunity. Understanding the duration of natural immunity to cholera can help guide control strategies and policy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 5 e0009383 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tiffany Leung Laura Matrajt Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Cholera is an acute, diarrheal disease caused by Vibrio cholerae O1 or 139 that is associated with a high global burden. Methods We analyzed the estimated duration of immunity following cholera infection from available published studies. We searched PubMed and Web of Science for studies of the long-term immunity following cholera infection. We identified 22 eligible studies and categorized them as either observational, challenge, or serological. Results We found strong evidence of protection at 3 years after infection in observational and challenge studies. However, serological studies show that elevated humoral markers of potential correlates of protection returned to baseline within 1 year. Additionally, a subclinical cholera infection may confer lower protection than a clinical one, as suggested by 3 studies that found that, albeit with small sample sizes, most participants with a subclinical infection from an initial challenge with cholera had a symptomatic infection when rechallenged with a homologous biotype. Conclusions This review underscores the need to elucidate potential differences in the protection provided by clinical and subclinical cholera infections. Further, more studies are warranted to bridge the gap between the correlates of protection and cholera immunity. Understanding the duration of natural immunity to cholera can help guide control strategies and policy. |
format |
Article in Journal/Newspaper |
author |
Tiffany Leung Laura Matrajt |
author_facet |
Tiffany Leung Laura Matrajt |
author_sort |
Tiffany Leung |
title |
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. |
title_short |
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. |
title_full |
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. |
title_fullStr |
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. |
title_full_unstemmed |
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review. |
title_sort |
protection afforded by previous vibrio cholerae infection against subsequent disease and infection: a review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009383 https://doaj.org/article/500a662489354eeba9e469e2c1e9e71b |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009383 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009383 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009383 https://doaj.org/article/500a662489354eeba9e469e2c1e9e71b |
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https://doi.org/10.1371/journal.pntd.0009383 |
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PLOS Neglected Tropical Diseases |
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