Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review
Anthocyanins (ACN) are water-soluble pigments, belonging to flavonoids, and are present in almost all fruits, and vegetables at varying concentration. About 635 ACN were distinguished based on the position and number of methoxyl and hydroxyl moieties in the basic structure of ACN. Pelargonidin, cyan...
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ftdoajarticles:oai:doaj.org/article:4fe8313035a448178daa8e3ec31dfdc8 2023-05-15T15:07:45+02:00 Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Kumaresan Subasankari Chaiyavat Chaiyasut 2018-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.244137 https://doaj.org/article/4fe8313035a448178daa8e3ec31dfdc8 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=10;spage=471;epage=477;aulast=Sivamaruthi https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.244137 https://doaj.org/article/4fe8313035a448178daa8e3ec31dfdc8 Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 10, Pp 471-477 (2018) anthocyanins flavonoids diabetes cyanidin 3-o-β-d-glucoside insulin sensitivity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.4103/2221-1691.244137 2022-12-31T06:00:09Z Anthocyanins (ACN) are water-soluble pigments, belonging to flavonoids, and are present in almost all fruits, and vegetables at varying concentration. About 635 ACN were distinguished based on the position and number of methoxyl and hydroxyl moieties in the basic structure of ACN. Pelargonidin, cyanidin, delphinidin, malvidin, peonidin, and petunidin are extensively studied anthocyanidins. The absorption, bioavailability, metabolism, pharmacokinetics, molecular mechanism, and analytical techniques of several phytochemicals were described. The biological benefits (antidiabetic, anti-neuro-disorder, anti-cardiovascular diseases, antigastrointestinal diseases, and disorders) of flavonoids and ACN have been reported. Several in vitro, and in vivo reports demonstrated that ACN-rich plant extracts ameliorate the diabetes-associated consequences by reducing the glucose absorption, ROS production, oxidative stress, glomerular angiogenesis, lipid synthesis, and FoxO1 and adipose triglyceride lipase expressions, and improve the insulin secretion, insulin sensitivity, glucose tolerance, glucose uptake, glucose consumption, antioxidant activity. The literature search was made in Scopus, Google Scholar, PubMed using the keywords “anthocyanin” and “diabetes”. The documents were carefully checked for the relevance to the current manuscript and the selection was made without any chronological restriction. The present manuscript summarizes the updated reports on antihyperglycemic properties of ACN. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 8 10 471 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
anthocyanins flavonoids diabetes cyanidin 3-o-β-d-glucoside insulin sensitivity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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anthocyanins flavonoids diabetes cyanidin 3-o-β-d-glucoside insulin sensitivity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Kumaresan Subasankari Chaiyavat Chaiyasut Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review |
topic_facet |
anthocyanins flavonoids diabetes cyanidin 3-o-β-d-glucoside insulin sensitivity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Anthocyanins (ACN) are water-soluble pigments, belonging to flavonoids, and are present in almost all fruits, and vegetables at varying concentration. About 635 ACN were distinguished based on the position and number of methoxyl and hydroxyl moieties in the basic structure of ACN. Pelargonidin, cyanidin, delphinidin, malvidin, peonidin, and petunidin are extensively studied anthocyanidins. The absorption, bioavailability, metabolism, pharmacokinetics, molecular mechanism, and analytical techniques of several phytochemicals were described. The biological benefits (antidiabetic, anti-neuro-disorder, anti-cardiovascular diseases, antigastrointestinal diseases, and disorders) of flavonoids and ACN have been reported. Several in vitro, and in vivo reports demonstrated that ACN-rich plant extracts ameliorate the diabetes-associated consequences by reducing the glucose absorption, ROS production, oxidative stress, glomerular angiogenesis, lipid synthesis, and FoxO1 and adipose triglyceride lipase expressions, and improve the insulin secretion, insulin sensitivity, glucose tolerance, glucose uptake, glucose consumption, antioxidant activity. The literature search was made in Scopus, Google Scholar, PubMed using the keywords “anthocyanin” and “diabetes”. The documents were carefully checked for the relevance to the current manuscript and the selection was made without any chronological restriction. The present manuscript summarizes the updated reports on antihyperglycemic properties of ACN. |
format |
Article in Journal/Newspaper |
author |
Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Kumaresan Subasankari Chaiyavat Chaiyasut |
author_facet |
Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Kumaresan Subasankari Chaiyavat Chaiyasut |
author_sort |
Bhagavathi Sundaram Sivamaruthi |
title |
Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review |
title_short |
Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review |
title_full |
Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review |
title_fullStr |
Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review |
title_full_unstemmed |
Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review |
title_sort |
beneficial effects of anthocyanins against diabetes mellitus associated consequences-a mini review |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/2221-1691.244137 https://doaj.org/article/4fe8313035a448178daa8e3ec31dfdc8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 10, Pp 471-477 (2018) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=10;spage=471;epage=477;aulast=Sivamaruthi https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.244137 https://doaj.org/article/4fe8313035a448178daa8e3ec31dfdc8 |
op_doi |
https://doi.org/10.4103/2221-1691.244137 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
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8 |
container_issue |
10 |
container_start_page |
471 |
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