Remission of adult-onset asthma is rare: a 15-year follow-up study
Background There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. Methods A cohort of 309 adults aged 20–60 years wit...
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ftdoajarticles:oai:doaj.org/article:4f9bbb67c7fc476f9fa1aef91cb71996 2023-05-15T17:44:57+02:00 Remission of adult-onset asthma is rare: a 15-year follow-up study Linnéa Almqvist Eva Rönmark Caroline Stridsman Helena Backman Anne Lindberg Bo Lundbäck Linnéa Hedman 2020-11-01T00:00:00Z https://doi.org/10.1183/23120541.00620-2020 https://doaj.org/article/4f9bbb67c7fc476f9fa1aef91cb71996 EN eng European Respiratory Society http://openres.ersjournals.com/content/6/4/00620-2020.full https://doaj.org/toc/2312-0541 2312-0541 doi:10.1183/23120541.00620-2020 https://doaj.org/article/4f9bbb67c7fc476f9fa1aef91cb71996 ERJ Open Research, Vol 6, Iss 4 (2020) Medicine R article 2020 ftdoajarticles https://doi.org/10.1183/23120541.00620-2020 2022-12-31T06:15:21Z Background There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. Methods A cohort of 309 adults aged 20–60 years with asthma onset during the last 12 months verified by bronchial variability, was recruited between 1995 and 1999 from the general population in northern Sweden. The cohort was followed-up in 2003 (n=250) and between 2012 and 2014 (n=205). Structured interviews and spirometry were performed at recruitment and the follow-ups. Bronchial hyperreactivity (BHR) and skin-prick tests were performed at recruitment and blood samples were collected at the last follow-up. Remission of asthma was defined as no asthma symptoms and no use of asthma medication during the last 12 months. Results Of eight individuals in remission in 2003, five had relapsed between 2012 and 2014 and in total, 23 (11%) were in remission, while 182 had persistent asthma. Those in remission had higher mean forced expiratory volume in 1 s % predicted at recruitment than those with persistent asthma (94.6 versus 88.3, p=0.034), fewer had severe BHR (27.3% versus 50.9%, p=0.037) and they had less body mass index increase (+1.6 versus +3.0, p=0.054). Of those with persistent asthma, 13% had uncontrolled asthma and they had higher levels of blood neutrophils than those with partly controlled or controlled asthma. Conclusion Higher forced expiratory volume in 1 s % predicted and less-severe BHR was associated with remission of adult-onset asthma, but still, the proportion in remission in this 15-year follow-up was low. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles ERJ Open Research 6 4 00620-2020 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Medicine R |
spellingShingle |
Medicine R Linnéa Almqvist Eva Rönmark Caroline Stridsman Helena Backman Anne Lindberg Bo Lundbäck Linnéa Hedman Remission of adult-onset asthma is rare: a 15-year follow-up study |
topic_facet |
Medicine R |
description |
Background There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. Methods A cohort of 309 adults aged 20–60 years with asthma onset during the last 12 months verified by bronchial variability, was recruited between 1995 and 1999 from the general population in northern Sweden. The cohort was followed-up in 2003 (n=250) and between 2012 and 2014 (n=205). Structured interviews and spirometry were performed at recruitment and the follow-ups. Bronchial hyperreactivity (BHR) and skin-prick tests were performed at recruitment and blood samples were collected at the last follow-up. Remission of asthma was defined as no asthma symptoms and no use of asthma medication during the last 12 months. Results Of eight individuals in remission in 2003, five had relapsed between 2012 and 2014 and in total, 23 (11%) were in remission, while 182 had persistent asthma. Those in remission had higher mean forced expiratory volume in 1 s % predicted at recruitment than those with persistent asthma (94.6 versus 88.3, p=0.034), fewer had severe BHR (27.3% versus 50.9%, p=0.037) and they had less body mass index increase (+1.6 versus +3.0, p=0.054). Of those with persistent asthma, 13% had uncontrolled asthma and they had higher levels of blood neutrophils than those with partly controlled or controlled asthma. Conclusion Higher forced expiratory volume in 1 s % predicted and less-severe BHR was associated with remission of adult-onset asthma, but still, the proportion in remission in this 15-year follow-up was low. |
format |
Article in Journal/Newspaper |
author |
Linnéa Almqvist Eva Rönmark Caroline Stridsman Helena Backman Anne Lindberg Bo Lundbäck Linnéa Hedman |
author_facet |
Linnéa Almqvist Eva Rönmark Caroline Stridsman Helena Backman Anne Lindberg Bo Lundbäck Linnéa Hedman |
author_sort |
Linnéa Almqvist |
title |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_short |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_full |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_fullStr |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_full_unstemmed |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_sort |
remission of adult-onset asthma is rare: a 15-year follow-up study |
publisher |
European Respiratory Society |
publishDate |
2020 |
url |
https://doi.org/10.1183/23120541.00620-2020 https://doaj.org/article/4f9bbb67c7fc476f9fa1aef91cb71996 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
ERJ Open Research, Vol 6, Iss 4 (2020) |
op_relation |
http://openres.ersjournals.com/content/6/4/00620-2020.full https://doaj.org/toc/2312-0541 2312-0541 doi:10.1183/23120541.00620-2020 https://doaj.org/article/4f9bbb67c7fc476f9fa1aef91cb71996 |
op_doi |
https://doi.org/10.1183/23120541.00620-2020 |
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ERJ Open Research |
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6 |
container_issue |
4 |
container_start_page |
00620-2020 |
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