The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study.
Background Congenital TORCH (Toxoplasma gondii (T. gondii), rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV)) infections are associated with a variety of adverse prenatal and neonatal events, including miscarriage, malformations and developmental abnormalities, and they rema...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0010861 https://doaj.org/article/4f79fc9b606c48cf84d817e84652567d |
id |
ftdoajarticles:oai:doaj.org/article:4f79fc9b606c48cf84d817e84652567d |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:4f79fc9b606c48cf84d817e84652567d 2023-05-15T15:12:17+02:00 The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. Linlin Zhang Xinyu Wang Mengjia Liu Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie 2022-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010861 https://doaj.org/article/4f79fc9b606c48cf84d817e84652567d EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010861 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010861 https://doaj.org/article/4f79fc9b606c48cf84d817e84652567d PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010861 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010861 2022-12-30T19:39:34Z Background Congenital TORCH (Toxoplasma gondii (T. gondii), rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV)) infections are associated with a variety of adverse prenatal and neonatal events, including miscarriage, malformations and developmental abnormalities, and they remain an issue that cannot be neglected in China. However, the current research focuses more on the general screening of TORCH in women of childbearing age, and the medical information of children hospitalized due to congenital and perinatal TORCH infections has not been described in detail. This study summarized and analyzed the epidemiological characteristics, clinical manifestations, length of stay (LOS), and the disease burden of hospitalized children diagnosed with congenital TORCH infections in 27 children's hospitals in China. Methodology Based on the face sheet of discharge medical records (FSMRs) of hospitalized children in 27 tertiary children's hospitals collected in the Futang Research Center of Pediatric Development and aggregated into FUTang Update medical REcords (FUTURE), we summarized and analyzed the epidemiological characteristics, clinical manifestations, LOS, the disease burden (in US dollars, USD) and potential risk factors for hospitalized children diagnosed with congenital toxoplasmosis, congenital rubella syndrome, congenital cytomegalovirus infection, and congenital HSV in 27 children's hospitals in China from 2015 to 2020. Results One hundred seventy-three patients aged 0-<1 year were hospitalized for congenital TORCH infections. Among infections with TORCH, hospitalization with congenital toxoplasmosis was the least common, with only five cases were reported (2.89%), while the LOS was the highest. The proportion of patients with congenital rubella syndrome (CRS) was 15.61%, and 86% of children hospitalized with CRS had cardiovascular malformations, and the economic burden was the highest. Congenital CMV infection cases accounted for the largest proportion (76.30%). Overall, 5.20% of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 10 e0010861 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Linlin Zhang Xinyu Wang Mengjia Liu Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Congenital TORCH (Toxoplasma gondii (T. gondii), rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV)) infections are associated with a variety of adverse prenatal and neonatal events, including miscarriage, malformations and developmental abnormalities, and they remain an issue that cannot be neglected in China. However, the current research focuses more on the general screening of TORCH in women of childbearing age, and the medical information of children hospitalized due to congenital and perinatal TORCH infections has not been described in detail. This study summarized and analyzed the epidemiological characteristics, clinical manifestations, length of stay (LOS), and the disease burden of hospitalized children diagnosed with congenital TORCH infections in 27 children's hospitals in China. Methodology Based on the face sheet of discharge medical records (FSMRs) of hospitalized children in 27 tertiary children's hospitals collected in the Futang Research Center of Pediatric Development and aggregated into FUTang Update medical REcords (FUTURE), we summarized and analyzed the epidemiological characteristics, clinical manifestations, LOS, the disease burden (in US dollars, USD) and potential risk factors for hospitalized children diagnosed with congenital toxoplasmosis, congenital rubella syndrome, congenital cytomegalovirus infection, and congenital HSV in 27 children's hospitals in China from 2015 to 2020. Results One hundred seventy-three patients aged 0-<1 year were hospitalized for congenital TORCH infections. Among infections with TORCH, hospitalization with congenital toxoplasmosis was the least common, with only five cases were reported (2.89%), while the LOS was the highest. The proportion of patients with congenital rubella syndrome (CRS) was 15.61%, and 86% of children hospitalized with CRS had cardiovascular malformations, and the economic burden was the highest. Congenital CMV infection cases accounted for the largest proportion (76.30%). Overall, 5.20% of ... |
format |
Article in Journal/Newspaper |
author |
Linlin Zhang Xinyu Wang Mengjia Liu Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie |
author_facet |
Linlin Zhang Xinyu Wang Mengjia Liu Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie |
author_sort |
Linlin Zhang |
title |
The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. |
title_short |
The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. |
title_full |
The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. |
title_fullStr |
The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. |
title_full_unstemmed |
The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. |
title_sort |
epidemiology and disease burden of congenital torch infections among hospitalized children in china: a national cross-sectional study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010861 https://doaj.org/article/4f79fc9b606c48cf84d817e84652567d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010861 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010861 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010861 https://doaj.org/article/4f79fc9b606c48cf84d817e84652567d |
op_doi |
https://doi.org/10.1371/journal.pntd.0010861 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
10 |
container_start_page |
e0010861 |
_version_ |
1766342993649860608 |