A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa
Abstract Background Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual. Methods A cross-sectional study among HIV-1 infected and uninfected...
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ftdoajarticles:oai:doaj.org/article:4f28754da91041488c8b18bbab433043 2023-05-15T15:12:01+02:00 A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa Noormahomed Emilia V Orlov Marika do Rosario Virgilio Petersen Brett W Guthrie Carly Badaro Roberto Schooley Robert T 2012-08-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-252 https://doaj.org/article/4f28754da91041488c8b18bbab433043 EN eng BMC http://www.malariajournal.com/content/11/1/252 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-252 1475-2875 https://doaj.org/article/4f28754da91041488c8b18bbab433043 Malaria Journal, Vol 11, Iss 1, p 252 (2012) Malaria P. falciparum HIV-1 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-252 2023-01-08T01:37:57Z Abstract Background Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual. Methods A cross-sectional study among HIV-1 infected and uninfected populations was recruited in Mocuba and Maputo, Mozambique to determine the prevalence of sub-clinical malarial parasitaemia using light microscopy and a nested PCR assay. Results The prevalence of sub-clinical P. falciparum parasitaemia was low in Maputo, whether determined by microscopy (0.4%) or PCR (1.9%), but substantially higher in Mocuba (7.6 and 14.7%, respectively). Nested PCR detected nearly 70% more cases of sub-clinical parasitaemia than microscopy, but differences occur by locality. HIV-1 infected persons were more likely to be sub-clinically parasitaemic than HIV-1 uninfected individuals recruited from the same geographic areas. Trimethoprim-sulphamethoxazole use did not substantially reduce sub-clinical parasitaemia. Conclusions Dried blood spots are a convenient and sensitive technique for detecting sub-clinical infection with P. falciparum by nested PCR . Prevalence of P. falciparum is substantially lower in Maputo where malaria control programmes have been more active than in the rural town of Mocuba. In Mocuba, among those presenting for HIV-1 counseling and testing, the prevalence of P. falciparum is substantially higher in those who test positive for HIV-1 than those without HIV-1 infection. The clinical implications of sub-clinical P. falciparum infection among HIV-1 infected persons warrant additional study . Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 252 |
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English |
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Malaria P. falciparum HIV-1 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria P. falciparum HIV-1 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Noormahomed Emilia V Orlov Marika do Rosario Virgilio Petersen Brett W Guthrie Carly Badaro Roberto Schooley Robert T A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa |
topic_facet |
Malaria P. falciparum HIV-1 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual. Methods A cross-sectional study among HIV-1 infected and uninfected populations was recruited in Mocuba and Maputo, Mozambique to determine the prevalence of sub-clinical malarial parasitaemia using light microscopy and a nested PCR assay. Results The prevalence of sub-clinical P. falciparum parasitaemia was low in Maputo, whether determined by microscopy (0.4%) or PCR (1.9%), but substantially higher in Mocuba (7.6 and 14.7%, respectively). Nested PCR detected nearly 70% more cases of sub-clinical parasitaemia than microscopy, but differences occur by locality. HIV-1 infected persons were more likely to be sub-clinically parasitaemic than HIV-1 uninfected individuals recruited from the same geographic areas. Trimethoprim-sulphamethoxazole use did not substantially reduce sub-clinical parasitaemia. Conclusions Dried blood spots are a convenient and sensitive technique for detecting sub-clinical infection with P. falciparum by nested PCR . Prevalence of P. falciparum is substantially lower in Maputo where malaria control programmes have been more active than in the rural town of Mocuba. In Mocuba, among those presenting for HIV-1 counseling and testing, the prevalence of P. falciparum is substantially higher in those who test positive for HIV-1 than those without HIV-1 infection. The clinical implications of sub-clinical P. falciparum infection among HIV-1 infected persons warrant additional study . |
format |
Article in Journal/Newspaper |
author |
Noormahomed Emilia V Orlov Marika do Rosario Virgilio Petersen Brett W Guthrie Carly Badaro Roberto Schooley Robert T |
author_facet |
Noormahomed Emilia V Orlov Marika do Rosario Virgilio Petersen Brett W Guthrie Carly Badaro Roberto Schooley Robert T |
author_sort |
Noormahomed Emilia V |
title |
A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa |
title_short |
A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa |
title_full |
A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa |
title_fullStr |
A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa |
title_full_unstemmed |
A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa |
title_sort |
cross-sectional study of sub-clinical plasmodium falciparum infection in hiv-1 infected and uninfected populations in mozambique, south-eastern africa |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-252 https://doaj.org/article/4f28754da91041488c8b18bbab433043 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 252 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/252 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-252 1475-2875 https://doaj.org/article/4f28754da91041488c8b18bbab433043 |
op_doi |
https://doi.org/10.1186/1475-2875-11-252 |
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Malaria Journal |
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11 |
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1 |
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252 |
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