Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination.
Outside of Africa, P. falciparum and P. vivax usually coexist. In such co-endemic regions, successful malaria control programs have a greater impact on reducing falciparum malaria, resulting in P. vivax becoming the predominant species of infection. Adding to the challenges of elimination, the dorma...
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ftdoajarticles:oai:doaj.org/article:4f1ce2242469491385bc4b068de25bc6 2023-05-15T15:15:17+02:00 Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. Rintis Noviyanti Farah Coutrier Retno A S Utami Hidayat Trimarsanto Yusrifar K Tirta Leily Trianty Andreas Kusuma Inge Sutanto Ayleen Kosasih Rita Kusriastuti William A Hawley Ferdinand Laihad Neil Lobo Jutta Marfurt Taane G Clark Ric N Price Sarah Auburn 2015-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003739 https://doaj.org/article/4f1ce2242469491385bc4b068de25bc6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4423885?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003739 https://doaj.org/article/4f1ce2242469491385bc4b068de25bc6 PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003739 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003739 2022-12-31T14:52:19Z Outside of Africa, P. falciparum and P. vivax usually coexist. In such co-endemic regions, successful malaria control programs have a greater impact on reducing falciparum malaria, resulting in P. vivax becoming the predominant species of infection. Adding to the challenges of elimination, the dormant liver stage complicates efforts to monitor the impact of ongoing interventions against P. vivax. We investigated molecular approaches to inform the respective transmission dynamics of P. falciparum and P. vivax and how these could help to prioritize public health interventions.Genotype data generated at 8 and 9 microsatellite loci were analysed in 168 P. falciparum and 166 P. vivax isolates, respectively, from four co-endemic sites in Indonesia (Bangka, Kalimantan, Sumba and West Timor). Measures of diversity, linkage disequilibrium (LD) and population structure were used to gauge the transmission dynamics of each species in each setting. Marked differences were observed in the diversity and population structure of P. vivax versus P. falciparum. In Bangka, Kalimantan and Timor, P. falciparum diversity was low, and LD patterns were consistent with unstable, epidemic transmission, amenable to targeted intervention. In contrast, P. vivax diversity was higher and transmission appeared more stable. Population differentiation was lower in P. vivax versus P. falciparum, suggesting that the hypnozoite reservoir might play an important role in sustaining local transmission and facilitating the spread of P. vivax infections in different endemic settings. P. vivax polyclonality varied with local endemicity, demonstrating potential utility in informing on transmission intensity in this species.Molecular approaches can provide important information on malaria transmission that is not readily available from traditional epidemiological measures. Elucidation of the transmission dynamics circulating in a given setting will have a major role in prioritising malaria control strategies, particularly against the relatively neglected ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sumba ENVELOPE(-6.712,-6.712,61.403,61.403) PLOS Neglected Tropical Diseases 9 5 e0003739 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rintis Noviyanti Farah Coutrier Retno A S Utami Hidayat Trimarsanto Yusrifar K Tirta Leily Trianty Andreas Kusuma Inge Sutanto Ayleen Kosasih Rita Kusriastuti William A Hawley Ferdinand Laihad Neil Lobo Jutta Marfurt Taane G Clark Ric N Price Sarah Auburn Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Outside of Africa, P. falciparum and P. vivax usually coexist. In such co-endemic regions, successful malaria control programs have a greater impact on reducing falciparum malaria, resulting in P. vivax becoming the predominant species of infection. Adding to the challenges of elimination, the dormant liver stage complicates efforts to monitor the impact of ongoing interventions against P. vivax. We investigated molecular approaches to inform the respective transmission dynamics of P. falciparum and P. vivax and how these could help to prioritize public health interventions.Genotype data generated at 8 and 9 microsatellite loci were analysed in 168 P. falciparum and 166 P. vivax isolates, respectively, from four co-endemic sites in Indonesia (Bangka, Kalimantan, Sumba and West Timor). Measures of diversity, linkage disequilibrium (LD) and population structure were used to gauge the transmission dynamics of each species in each setting. Marked differences were observed in the diversity and population structure of P. vivax versus P. falciparum. In Bangka, Kalimantan and Timor, P. falciparum diversity was low, and LD patterns were consistent with unstable, epidemic transmission, amenable to targeted intervention. In contrast, P. vivax diversity was higher and transmission appeared more stable. Population differentiation was lower in P. vivax versus P. falciparum, suggesting that the hypnozoite reservoir might play an important role in sustaining local transmission and facilitating the spread of P. vivax infections in different endemic settings. P. vivax polyclonality varied with local endemicity, demonstrating potential utility in informing on transmission intensity in this species.Molecular approaches can provide important information on malaria transmission that is not readily available from traditional epidemiological measures. Elucidation of the transmission dynamics circulating in a given setting will have a major role in prioritising malaria control strategies, particularly against the relatively neglected ... |
format |
Article in Journal/Newspaper |
author |
Rintis Noviyanti Farah Coutrier Retno A S Utami Hidayat Trimarsanto Yusrifar K Tirta Leily Trianty Andreas Kusuma Inge Sutanto Ayleen Kosasih Rita Kusriastuti William A Hawley Ferdinand Laihad Neil Lobo Jutta Marfurt Taane G Clark Ric N Price Sarah Auburn |
author_facet |
Rintis Noviyanti Farah Coutrier Retno A S Utami Hidayat Trimarsanto Yusrifar K Tirta Leily Trianty Andreas Kusuma Inge Sutanto Ayleen Kosasih Rita Kusriastuti William A Hawley Ferdinand Laihad Neil Lobo Jutta Marfurt Taane G Clark Ric N Price Sarah Auburn |
author_sort |
Rintis Noviyanti |
title |
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. |
title_short |
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. |
title_full |
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. |
title_fullStr |
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. |
title_full_unstemmed |
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. |
title_sort |
contrasting transmission dynamics of co-endemic plasmodium vivax and p. falciparum: implications for malaria control and elimination. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003739 https://doaj.org/article/4f1ce2242469491385bc4b068de25bc6 |
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ENVELOPE(-6.712,-6.712,61.403,61.403) |
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Arctic Sumba |
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Arctic Sumba |
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Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003739 (2015) |
op_relation |
http://europepmc.org/articles/PMC4423885?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003739 https://doaj.org/article/4f1ce2242469491385bc4b068de25bc6 |
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https://doi.org/10.1371/journal.pntd.0003739 |
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PLOS Neglected Tropical Diseases |
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