Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1).
Highly pathogenic avian influenza virus (HPAIV) continues to threaten human health. Non-human primate infection models of human influenza are desired. To establish an animal infection model with more natural transmission and to determine the pathogenicity of HPAIV isolated from a wild water bird in...
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Online Access: | https://doi.org/10.1371/journal.pone.0083551 https://doaj.org/article/4f08ff26056f4d4e978e5cd527117f64 |
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ftdoajarticles:oai:doaj.org/article:4f08ff26056f4d4e978e5cd527117f64 2023-05-15T18:44:12+02:00 Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). Tomoko Fujiyuki Misako Yoneda Fumihiko Yasui Takeshi Kuraishi Shosaku Hattori Hyun-Jeong Kwon Keisuke Munekata Yuri Kiso Hiroshi Kida Michinori Kohara Chieko Kai 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0083551 https://doaj.org/article/4f08ff26056f4d4e978e5cd527117f64 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3867452?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0083551 https://doaj.org/article/4f08ff26056f4d4e978e5cd527117f64 PLoS ONE, Vol 8, Iss 12, p e83551 (2013) Medicine R Science Q article 2013 ftdoajarticles https://doi.org/10.1371/journal.pone.0083551 2022-12-31T10:44:43Z Highly pathogenic avian influenza virus (HPAIV) continues to threaten human health. Non-human primate infection models of human influenza are desired. To establish an animal infection model with more natural transmission and to determine the pathogenicity of HPAIV isolated from a wild water bird in primates, we administered a Japanese isolate of HPAIV (A/whooper swan/Hokkaido/1/2008, H5N1 clade 2.3.2.1) to rhesus and cynomolgus monkeys, in droplet form, via the intratracheal route. Infection of the lower and upper respiratory tracts and viral shedding were observed in both macaques. Inoculation of rhesus monkeys with higher doses of the isolate resulted in stronger clinical symptoms of influenza. Our results demonstrate that HPAIV isolated from a water bird in Japan is pathogenic in monkeys by experimental inoculation, and provide a new method for HPAIV infection of non-human primate hosts, a good animal model for investigation of HPAIV pathogenicity. Article in Journal/Newspaper Whooper Swan Directory of Open Access Journals: DOAJ Articles PLoS ONE 8 12 e83551 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Tomoko Fujiyuki Misako Yoneda Fumihiko Yasui Takeshi Kuraishi Shosaku Hattori Hyun-Jeong Kwon Keisuke Munekata Yuri Kiso Hiroshi Kida Michinori Kohara Chieko Kai Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). |
topic_facet |
Medicine R Science Q |
description |
Highly pathogenic avian influenza virus (HPAIV) continues to threaten human health. Non-human primate infection models of human influenza are desired. To establish an animal infection model with more natural transmission and to determine the pathogenicity of HPAIV isolated from a wild water bird in primates, we administered a Japanese isolate of HPAIV (A/whooper swan/Hokkaido/1/2008, H5N1 clade 2.3.2.1) to rhesus and cynomolgus monkeys, in droplet form, via the intratracheal route. Infection of the lower and upper respiratory tracts and viral shedding were observed in both macaques. Inoculation of rhesus monkeys with higher doses of the isolate resulted in stronger clinical symptoms of influenza. Our results demonstrate that HPAIV isolated from a water bird in Japan is pathogenic in monkeys by experimental inoculation, and provide a new method for HPAIV infection of non-human primate hosts, a good animal model for investigation of HPAIV pathogenicity. |
format |
Article in Journal/Newspaper |
author |
Tomoko Fujiyuki Misako Yoneda Fumihiko Yasui Takeshi Kuraishi Shosaku Hattori Hyun-Jeong Kwon Keisuke Munekata Yuri Kiso Hiroshi Kida Michinori Kohara Chieko Kai |
author_facet |
Tomoko Fujiyuki Misako Yoneda Fumihiko Yasui Takeshi Kuraishi Shosaku Hattori Hyun-Jeong Kwon Keisuke Munekata Yuri Kiso Hiroshi Kida Michinori Kohara Chieko Kai |
author_sort |
Tomoko Fujiyuki |
title |
Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). |
title_short |
Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). |
title_full |
Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). |
title_fullStr |
Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). |
title_full_unstemmed |
Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). |
title_sort |
experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (h5n1). |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pone.0083551 https://doaj.org/article/4f08ff26056f4d4e978e5cd527117f64 |
genre |
Whooper Swan |
genre_facet |
Whooper Swan |
op_source |
PLoS ONE, Vol 8, Iss 12, p e83551 (2013) |
op_relation |
http://europepmc.org/articles/PMC3867452?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0083551 https://doaj.org/article/4f08ff26056f4d4e978e5cd527117f64 |
op_doi |
https://doi.org/10.1371/journal.pone.0083551 |
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PLoS ONE |
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8 |
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12 |
container_start_page |
e83551 |
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1766234791082983424 |