How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature

• Main Authors: El-Sheekh MM, AlKafaas SS, Rady HA, Abdelmoaty BE, Bedair HM, Ahmed AA, El-Saadony MT, AbuQamar SF, El-Tarabily KA
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2023
• Subjects: algae; metabolites; cancer therapy; green synthesis; medical applications; nanoparticles; Medicine (General); R5-920; sami
• Online Access: https://doaj.org/article/4e4a5590fd754b788df66e436d1d68d6

Mostafa M El-Sheekh,1 Samar Sami AlKafaas,2 Hadeer A Rady,1 Bassant E Abdelmoaty,2 Heba M Bedair,1 Abdelhamid A Ahmed,3 Mohamed T El-Saadony,4 Synan F AbuQamar,5 Khaled A El-Tarabily5 1Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 2Molecular Cell Biology Unit, Division of Biochemistry, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 3Plastic Surgery Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt; 4Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt; 5Department of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab EmiratesCorrespondence: Synan F AbuQamar; Khaled A El-Tarabily, Department of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab Emirates, Tel [phone] [phone], Fax [phone], Email [e-mail]; [e-mail]: The necessity to engineer sustainable nanomaterials for the environment and human health has recently increased. Due to their abundance, fast growth, easy cultivation, biocompatibility and richness of secondary metabolites, algae are valuable biological source for the green synthesis of nanoparticles (NPs). The aim of this review is to demonstrate the feasibility of using algal-based NPs for cancer treatment. Blue-green, brown, red and green micro- and macro-algae are the most commonly participating algae in the green synthesis of NPs. In this process, many algal bioactive compounds, such as proteins, carbohydrates, lipids, alkaloids, flavonoids and phenols, can catalyze the reduction of metal ions to NPs. In addition, many driving factors, including pH, temperature, duration, static conditions and substrate concentration, are involved to facilitate the green synthesis of algal-based NPs. Here, the biosynthesis, mechanisms and applications of algal-synthesized NPs in cancer therapy have been critically discussed. We also reviewed the ...