The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti.
The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embry...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0006307 https://doaj.org/article/4de1c2eeb4b04fcebe3ad854f8a7cd4c |
id |
ftdoajarticles:oai:doaj.org/article:4de1c2eeb4b04fcebe3ad854f8a7cd4c |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:4de1c2eeb4b04fcebe3ad854f8a7cd4c 2023-05-15T15:06:30+02:00 The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. Chia-Hao Chang Yu-Ting Liu Shih-Che Weng I-Yi Chen Po-Nien Tsao Shin-Hong Shiao 2018-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006307 https://doaj.org/article/4de1c2eeb4b04fcebe3ad854f8a7cd4c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5854436?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006307 https://doaj.org/article/4de1c2eeb4b04fcebe3ad854f8a7cd4c PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006307 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006307 2022-12-31T05:44:55Z The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. However, functions of Notch signaling in Aedes aegypti, the major mosquito vector for dengue, are largely unknown. In this study, we identified a unique feature of A. aegypti Notch (AaNotch) in the control of the sterile-like phenotype in female mosquitoes. Silencing AaNotch with a reverse genetic approach significantly reduced the fecundity and fertility of the mosquito. Silencing AaNotch also resulted in the prevention of micropyle formation, which led to impaired fertilization. In addition, JNK phosphorylation (a signaling molecule in the non-canonical Notch signaling pathway) was inhibited in the absence of AaNotch. Furthermore, treatment with a JNK inhibitor in the mosquito resulted in impaired fecundity and fertility. Taken together, our results demonstrate that non-canonical Notch signaling is essential for controlling fertility in the A. aegypti mosquito. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 3 e0006307 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Chia-Hao Chang Yu-Ting Liu Shih-Che Weng I-Yi Chen Po-Nien Tsao Shin-Hong Shiao The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. However, functions of Notch signaling in Aedes aegypti, the major mosquito vector for dengue, are largely unknown. In this study, we identified a unique feature of A. aegypti Notch (AaNotch) in the control of the sterile-like phenotype in female mosquitoes. Silencing AaNotch with a reverse genetic approach significantly reduced the fecundity and fertility of the mosquito. Silencing AaNotch also resulted in the prevention of micropyle formation, which led to impaired fertilization. In addition, JNK phosphorylation (a signaling molecule in the non-canonical Notch signaling pathway) was inhibited in the absence of AaNotch. Furthermore, treatment with a JNK inhibitor in the mosquito resulted in impaired fecundity and fertility. Taken together, our results demonstrate that non-canonical Notch signaling is essential for controlling fertility in the A. aegypti mosquito. |
format |
Article in Journal/Newspaper |
author |
Chia-Hao Chang Yu-Ting Liu Shih-Che Weng I-Yi Chen Po-Nien Tsao Shin-Hong Shiao |
author_facet |
Chia-Hao Chang Yu-Ting Liu Shih-Che Weng I-Yi Chen Po-Nien Tsao Shin-Hong Shiao |
author_sort |
Chia-Hao Chang |
title |
The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. |
title_short |
The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. |
title_full |
The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. |
title_fullStr |
The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. |
title_full_unstemmed |
The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti. |
title_sort |
non-canonical notch signaling is essential for the control of fertility in aedes aegypti. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006307 https://doaj.org/article/4de1c2eeb4b04fcebe3ad854f8a7cd4c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006307 (2018) |
op_relation |
http://europepmc.org/articles/PMC5854436?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006307 https://doaj.org/article/4de1c2eeb4b04fcebe3ad854f8a7cd4c |
op_doi |
https://doi.org/10.1371/journal.pntd.0006307 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
3 |
container_start_page |
e0006307 |
_version_ |
1766338091274993664 |