Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children
Abstract Background It is important to establish whether or not the presence of malaria parasites in peripheral blood of asymptomatic individuals is a predictor of future clinical mild malaria attacks (MMA). The aim of this study was to determine how an asymptomatic positive thick blood smear could...
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ftdoajarticles:oai:doaj.org/article:4dde862e754547d79fca2d14cdce8ec6 2023-05-15T15:16:07+02:00 Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children Migot-Nabias Florence Gaye Oumar Etard Jean-François Cot Michel Le Port Agnès Garcia André 2008-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-193 https://doaj.org/article/4dde862e754547d79fca2d14cdce8ec6 EN eng BMC http://www.malariajournal.com/content/7/1/193 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-193 1475-2875 https://doaj.org/article/4dde862e754547d79fca2d14cdce8ec6 Malaria Journal, Vol 7, Iss 1, p 193 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-193 2022-12-30T22:25:28Z Abstract Background It is important to establish whether or not the presence of malaria parasites in peripheral blood of asymptomatic individuals is a predictor of future clinical mild malaria attacks (MMA). The aim of this study was to determine how an asymptomatic positive thick blood smear could be related to the occurrence of a MMA during the nine following days. Methods The study was conducted in a cohort of 569 Senegalese children, who were investigated for Plasmodium falciparum asymptomatic carriage at two different times of the transmission season, the beginning (September) and the end (November). The occurrence of MMA was investigated in asymptomatic carriers and non-carriers, every three days for nine consecutive days. Survival analysis was performed and risk estimates were calculated by Cox proportional hazards model. Results At the beginning of the transmission season, 27.8% (147/529) of the children were asymptomatic carriers (ACs) and 5.4% (8/147) of MMA occurred among these, versus 1% (4/382) among non-carriers (RR = 5.32; IC = [1.56–18.15], p = 0.008). At the end of the transmission season, the frequency of asymptomatic carriers was similar to that observed at the beginning of the season (31.9%, p = 0.15), but no MMA was detected during this period. Conclusion A significant association between P. falciparum asymptomatic carriage and the occurrence of MMA at the beginning of the transmission season was demonstrated, with a five-fold increase in the risk of developing a MMA in ACs. In the context of a possible distribution of IPTc in the future, drug strategies may have dramatic consequences due to the existence of ACs (both long term and short term), as they seem to play an important role in the individual protection to malaria, in the most exposed age groups. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Migot-Nabias Florence Gaye Oumar Etard Jean-François Cot Michel Le Port Agnès Garcia André Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background It is important to establish whether or not the presence of malaria parasites in peripheral blood of asymptomatic individuals is a predictor of future clinical mild malaria attacks (MMA). The aim of this study was to determine how an asymptomatic positive thick blood smear could be related to the occurrence of a MMA during the nine following days. Methods The study was conducted in a cohort of 569 Senegalese children, who were investigated for Plasmodium falciparum asymptomatic carriage at two different times of the transmission season, the beginning (September) and the end (November). The occurrence of MMA was investigated in asymptomatic carriers and non-carriers, every three days for nine consecutive days. Survival analysis was performed and risk estimates were calculated by Cox proportional hazards model. Results At the beginning of the transmission season, 27.8% (147/529) of the children were asymptomatic carriers (ACs) and 5.4% (8/147) of MMA occurred among these, versus 1% (4/382) among non-carriers (RR = 5.32; IC = [1.56–18.15], p = 0.008). At the end of the transmission season, the frequency of asymptomatic carriers was similar to that observed at the beginning of the season (31.9%, p = 0.15), but no MMA was detected during this period. Conclusion A significant association between P. falciparum asymptomatic carriage and the occurrence of MMA at the beginning of the transmission season was demonstrated, with a five-fold increase in the risk of developing a MMA in ACs. In the context of a possible distribution of IPTc in the future, drug strategies may have dramatic consequences due to the existence of ACs (both long term and short term), as they seem to play an important role in the individual protection to malaria, in the most exposed age groups. |
format |
Article in Journal/Newspaper |
author |
Migot-Nabias Florence Gaye Oumar Etard Jean-François Cot Michel Le Port Agnès Garcia André |
author_facet |
Migot-Nabias Florence Gaye Oumar Etard Jean-François Cot Michel Le Port Agnès Garcia André |
author_sort |
Migot-Nabias Florence |
title |
Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children |
title_short |
Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children |
title_full |
Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children |
title_fullStr |
Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children |
title_full_unstemmed |
Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children |
title_sort |
relation between plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of senegalese children |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-193 https://doaj.org/article/4dde862e754547d79fca2d14cdce8ec6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 193 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/193 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-193 1475-2875 https://doaj.org/article/4dde862e754547d79fca2d14cdce8ec6 |
op_doi |
https://doi.org/10.1186/1475-2875-7-193 |
container_title |
Malaria Journal |
container_volume |
7 |
container_issue |
1 |
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1766346418836996096 |