Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins suc...
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Online Access: | https://doi.org/10.3390/antibiotics10121481 https://doaj.org/article/4dd7e3893ec547edb7a7e95349d88e67 |
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ftdoajarticles:oai:doaj.org/article:4dd7e3893ec547edb7a7e95349d88e67 2023-05-15T18:07:47+02:00 Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection John Jairo Aguilera-Correa Sara Fernández-López Iskra Dennisse Cuñas-Figueroa Sandra Pérez-Rial Hanna-Leena Alakomi Liisa Nohynek Kirsi-Marja Oksman-Caldentey Juha-Pekka Salminen Jaime Esteban Juan Cuadros Riitta Puupponen-Pimiä Ramon Perez-Tanoira Teemu J. Kinnari 2021-12-01T00:00:00Z https://doi.org/10.3390/antibiotics10121481 https://doaj.org/article/4dd7e3893ec547edb7a7e95349d88e67 EN eng MDPI AG https://www.mdpi.com/2079-6382/10/12/1481 https://doaj.org/toc/2079-6382 doi:10.3390/antibiotics10121481 2079-6382 https://doaj.org/article/4dd7e3893ec547edb7a7e95349d88e67 Antibiotics, Vol 10, Iss 1481, p 1481 (2021) methicillin-resistant S. aureus biofilm cloudberry Rubus ellagitannin Therapeutics. Pharmacology RM1-950 article 2021 ftdoajarticles https://doi.org/10.3390/antibiotics10121481 2022-12-31T11:03:54Z Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. Article in Journal/Newspaper Rubus chamaemorus Directory of Open Access Journals: DOAJ Articles Antibiotics 10 12 1481 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
methicillin-resistant S. aureus biofilm cloudberry Rubus ellagitannin Therapeutics. Pharmacology RM1-950 |
spellingShingle |
methicillin-resistant S. aureus biofilm cloudberry Rubus ellagitannin Therapeutics. Pharmacology RM1-950 John Jairo Aguilera-Correa Sara Fernández-López Iskra Dennisse Cuñas-Figueroa Sandra Pérez-Rial Hanna-Leena Alakomi Liisa Nohynek Kirsi-Marja Oksman-Caldentey Juha-Pekka Salminen Jaime Esteban Juan Cuadros Riitta Puupponen-Pimiä Ramon Perez-Tanoira Teemu J. Kinnari Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
topic_facet |
methicillin-resistant S. aureus biofilm cloudberry Rubus ellagitannin Therapeutics. Pharmacology RM1-950 |
description |
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. |
format |
Article in Journal/Newspaper |
author |
John Jairo Aguilera-Correa Sara Fernández-López Iskra Dennisse Cuñas-Figueroa Sandra Pérez-Rial Hanna-Leena Alakomi Liisa Nohynek Kirsi-Marja Oksman-Caldentey Juha-Pekka Salminen Jaime Esteban Juan Cuadros Riitta Puupponen-Pimiä Ramon Perez-Tanoira Teemu J. Kinnari |
author_facet |
John Jairo Aguilera-Correa Sara Fernández-López Iskra Dennisse Cuñas-Figueroa Sandra Pérez-Rial Hanna-Leena Alakomi Liisa Nohynek Kirsi-Marja Oksman-Caldentey Juha-Pekka Salminen Jaime Esteban Juan Cuadros Riitta Puupponen-Pimiä Ramon Perez-Tanoira Teemu J. Kinnari |
author_sort |
John Jairo Aguilera-Correa |
title |
Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_short |
Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_full |
Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_fullStr |
Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_full_unstemmed |
Sanguiin H-6 Fractionated from Cloudberry ( Rubus chamaemorus ) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_sort |
sanguiin h-6 fractionated from cloudberry ( rubus chamaemorus ) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/antibiotics10121481 https://doaj.org/article/4dd7e3893ec547edb7a7e95349d88e67 |
genre |
Rubus chamaemorus |
genre_facet |
Rubus chamaemorus |
op_source |
Antibiotics, Vol 10, Iss 1481, p 1481 (2021) |
op_relation |
https://www.mdpi.com/2079-6382/10/12/1481 https://doaj.org/toc/2079-6382 doi:10.3390/antibiotics10121481 2079-6382 https://doaj.org/article/4dd7e3893ec547edb7a7e95349d88e67 |
op_doi |
https://doi.org/10.3390/antibiotics10121481 |
container_title |
Antibiotics |
container_volume |
10 |
container_issue |
12 |
container_start_page |
1481 |
_version_ |
1766180014005420032 |