Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice
The relationship among the phenotypes resistance to infection, virus replication in the brain and isotype production was investigated in genetically modified High (H) or Low (L) antibody responder mouse lines. Although they express the same innate susceptibility to rabies infection, these lines diff...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:4da5322c3f8342c7a3897aa0d0dd0a91 2023-05-15T15:10:05+02:00 Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice C. A. Consales C. A. Pereira E. C. Passos M. L. Carrieri N. M. F. Galina O. A. Sant'Anna 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000300007 https://doaj.org/article/4da5322c3f8342c7a3897aa0d0dd0a91 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000300007 1678-9199 https://doaj.org/article/4da5322c3f8342c7a3897aa0d0dd0a91 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 3, Pp 423-434 (2006) rabies infection isotypes nervous system Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000300007 2022-12-31T07:28:38Z The relationship among the phenotypes resistance to infection, virus replication in the brain and isotype production was investigated in genetically modified High (H) or Low (L) antibody responder mouse lines. Although they express the same innate susceptibility to rabies infection, these lines differ as to different viral replication rates in the central nervous system and L mice showed a higher permissible state. After intramuscular infection with the Pasteur rabies strain (PV), the H-L interline differences on the earlier stage of virus replication were 1000 and 80 folds on days 5 and 6, respectively. The isotype profile in sera of the experimentally infected mice reflected an interline difference of 25 folds for IgG2a throughout the infection period, and for the IgE production the H-L difference was highly significant only at the beginning of the process. These results confirm the multi-specific effect of antibody immune responsiveness and the general isotype distribution of antibodies in these genetically selected mice. Contrary to the clear correlation between antibody responsiveness and the acquired resistance to rabies infection, the present study demonstrates that the constitutive genetic character of High and Low responder individuals does not intervene in the degree of resistance following infection. Altogether, this study contributes to the knowledge of the protective role of the general innate responsiveness on the pathological pattern to rabies virus infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pasteur ENVELOPE(140.099,140.099,-66.625,-66.625) Journal of Venomous Animals and Toxins including Tropical Diseases 12 3 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
rabies infection isotypes nervous system Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
rabies infection isotypes nervous system Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 C. A. Consales C. A. Pereira E. C. Passos M. L. Carrieri N. M. F. Galina O. A. Sant'Anna Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
topic_facet |
rabies infection isotypes nervous system Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The relationship among the phenotypes resistance to infection, virus replication in the brain and isotype production was investigated in genetically modified High (H) or Low (L) antibody responder mouse lines. Although they express the same innate susceptibility to rabies infection, these lines differ as to different viral replication rates in the central nervous system and L mice showed a higher permissible state. After intramuscular infection with the Pasteur rabies strain (PV), the H-L interline differences on the earlier stage of virus replication were 1000 and 80 folds on days 5 and 6, respectively. The isotype profile in sera of the experimentally infected mice reflected an interline difference of 25 folds for IgG2a throughout the infection period, and for the IgE production the H-L difference was highly significant only at the beginning of the process. These results confirm the multi-specific effect of antibody immune responsiveness and the general isotype distribution of antibodies in these genetically selected mice. Contrary to the clear correlation between antibody responsiveness and the acquired resistance to rabies infection, the present study demonstrates that the constitutive genetic character of High and Low responder individuals does not intervene in the degree of resistance following infection. Altogether, this study contributes to the knowledge of the protective role of the general innate responsiveness on the pathological pattern to rabies virus infection. |
format |
Article in Journal/Newspaper |
author |
C. A. Consales C. A. Pereira E. C. Passos M. L. Carrieri N. M. F. Galina O. A. Sant'Anna |
author_facet |
C. A. Consales C. A. Pereira E. C. Passos M. L. Carrieri N. M. F. Galina O. A. Sant'Anna |
author_sort |
C. A. Consales |
title |
Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
title_short |
Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
title_full |
Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
title_fullStr |
Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
title_full_unstemmed |
Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
title_sort |
lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000300007 https://doaj.org/article/4da5322c3f8342c7a3897aa0d0dd0a91 |
long_lat |
ENVELOPE(140.099,140.099,-66.625,-66.625) |
geographic |
Arctic Pasteur |
geographic_facet |
Arctic Pasteur |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 3, Pp 423-434 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000300007 1678-9199 https://doaj.org/article/4da5322c3f8342c7a3897aa0d0dd0a91 |
op_doi |
https://doi.org/10.1590/S1678-91992006000300007 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
3 |
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1766341146667122688 |