Pharmacological characterization of rat paw edema induced by Naja haje arabica venom

This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10mug/paw) produced a dose and time-dependent increase in no...

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Published in:Journal of Venomous Animals and Toxins including Tropical Diseases
Main Author: A. K. Al-Asmari
Format: Article in Journal/Newspaper
Language:English
Published: SciELO 2005
Subjects:
Online Access:https://doi.org/10.1590/S1678-91992005000100007
https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426
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spelling ftdoajarticles:oai:doaj.org/article:4d8ecc8a5bb8400cbafacb0914c0a426 2023-05-15T15:05:34+02:00 Pharmacological characterization of rat paw edema induced by Naja haje arabica venom A. K. Al-Asmari 2005-03-01T00:00:00Z https://doi.org/10.1590/S1678-91992005000100007 https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000100007 1678-9199 https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 1, Pp 51-67 (2005) rat paw edema Naja haje arabica venom inflammatory mediators inhibitor antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2005 ftdoajarticles https://doi.org/10.1590/S1678-91992005000100007 2022-12-31T01:19:04Z This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10mug/paw) produced a dose and time-dependent increase in non-hemorrhagic paw edema. The response to NhaV was maximal within 15 min and disappeared in 24 h. Five mug/paw of NhaV was chosen to test the effect of various drugs on the edema induced by this venom. Quinacrine (QNC), a phospholipase A2 (PLA2) inhibitor, and dipyridamole (DPM), an adenosine transport inhibitor, attenuated venom-induced edema in rat paw (P<0.001). Commercially available antivenom was ineffective when administered intravenously, whereas its local administration with NhaV attenuated the edema formation (P<0.001). In conclusion, NhaV-induced edema in rat paw involves PLA2 and adenosine mechanisms. Additionally, the use of polyspecific antivenom, intravenously, was ineffective in preventing NhaV-induced edema. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 11 1
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic rat paw edema
Naja haje arabica venom
inflammatory mediators
inhibitor
antivenom
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
spellingShingle rat paw edema
Naja haje arabica venom
inflammatory mediators
inhibitor
antivenom
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
A. K. Al-Asmari
Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
topic_facet rat paw edema
Naja haje arabica venom
inflammatory mediators
inhibitor
antivenom
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
description This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10mug/paw) produced a dose and time-dependent increase in non-hemorrhagic paw edema. The response to NhaV was maximal within 15 min and disappeared in 24 h. Five mug/paw of NhaV was chosen to test the effect of various drugs on the edema induced by this venom. Quinacrine (QNC), a phospholipase A2 (PLA2) inhibitor, and dipyridamole (DPM), an adenosine transport inhibitor, attenuated venom-induced edema in rat paw (P<0.001). Commercially available antivenom was ineffective when administered intravenously, whereas its local administration with NhaV attenuated the edema formation (P<0.001). In conclusion, NhaV-induced edema in rat paw involves PLA2 and adenosine mechanisms. Additionally, the use of polyspecific antivenom, intravenously, was ineffective in preventing NhaV-induced edema.
format Article in Journal/Newspaper
author A. K. Al-Asmari
author_facet A. K. Al-Asmari
author_sort A. K. Al-Asmari
title Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
title_short Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
title_full Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
title_fullStr Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
title_full_unstemmed Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
title_sort pharmacological characterization of rat paw edema induced by naja haje arabica venom
publisher SciELO
publishDate 2005
url https://doi.org/10.1590/S1678-91992005000100007
https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 1, Pp 51-67 (2005)
op_relation http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100007
https://doaj.org/toc/1678-9199
doi:10.1590/S1678-91992005000100007
1678-9199
https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426
op_doi https://doi.org/10.1590/S1678-91992005000100007
container_title Journal of Venomous Animals and Toxins including Tropical Diseases
container_volume 11
container_issue 1
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