Pharmacological characterization of rat paw edema induced by Naja haje arabica venom
This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10mug/paw) produced a dose and time-dependent increase in no...
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ftdoajarticles:oai:doaj.org/article:4d8ecc8a5bb8400cbafacb0914c0a426 2023-05-15T15:05:34+02:00 Pharmacological characterization of rat paw edema induced by Naja haje arabica venom A. K. Al-Asmari 2005-03-01T00:00:00Z https://doi.org/10.1590/S1678-91992005000100007 https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000100007 1678-9199 https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 1, Pp 51-67 (2005) rat paw edema Naja haje arabica venom inflammatory mediators inhibitor antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2005 ftdoajarticles https://doi.org/10.1590/S1678-91992005000100007 2022-12-31T01:19:04Z This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10mug/paw) produced a dose and time-dependent increase in non-hemorrhagic paw edema. The response to NhaV was maximal within 15 min and disappeared in 24 h. Five mug/paw of NhaV was chosen to test the effect of various drugs on the edema induced by this venom. Quinacrine (QNC), a phospholipase A2 (PLA2) inhibitor, and dipyridamole (DPM), an adenosine transport inhibitor, attenuated venom-induced edema in rat paw (P<0.001). Commercially available antivenom was ineffective when administered intravenously, whereas its local administration with NhaV attenuated the edema formation (P<0.001). In conclusion, NhaV-induced edema in rat paw involves PLA2 and adenosine mechanisms. Additionally, the use of polyspecific antivenom, intravenously, was ineffective in preventing NhaV-induced edema. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 11 1 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
rat paw edema Naja haje arabica venom inflammatory mediators inhibitor antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
rat paw edema Naja haje arabica venom inflammatory mediators inhibitor antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 A. K. Al-Asmari Pharmacological characterization of rat paw edema induced by Naja haje arabica venom |
topic_facet |
rat paw edema Naja haje arabica venom inflammatory mediators inhibitor antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10mug/paw) produced a dose and time-dependent increase in non-hemorrhagic paw edema. The response to NhaV was maximal within 15 min and disappeared in 24 h. Five mug/paw of NhaV was chosen to test the effect of various drugs on the edema induced by this venom. Quinacrine (QNC), a phospholipase A2 (PLA2) inhibitor, and dipyridamole (DPM), an adenosine transport inhibitor, attenuated venom-induced edema in rat paw (P<0.001). Commercially available antivenom was ineffective when administered intravenously, whereas its local administration with NhaV attenuated the edema formation (P<0.001). In conclusion, NhaV-induced edema in rat paw involves PLA2 and adenosine mechanisms. Additionally, the use of polyspecific antivenom, intravenously, was ineffective in preventing NhaV-induced edema. |
format |
Article in Journal/Newspaper |
author |
A. K. Al-Asmari |
author_facet |
A. K. Al-Asmari |
author_sort |
A. K. Al-Asmari |
title |
Pharmacological characterization of rat paw edema induced by Naja haje arabica venom |
title_short |
Pharmacological characterization of rat paw edema induced by Naja haje arabica venom |
title_full |
Pharmacological characterization of rat paw edema induced by Naja haje arabica venom |
title_fullStr |
Pharmacological characterization of rat paw edema induced by Naja haje arabica venom |
title_full_unstemmed |
Pharmacological characterization of rat paw edema induced by Naja haje arabica venom |
title_sort |
pharmacological characterization of rat paw edema induced by naja haje arabica venom |
publisher |
SciELO |
publishDate |
2005 |
url |
https://doi.org/10.1590/S1678-91992005000100007 https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 1, Pp 51-67 (2005) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000100007 1678-9199 https://doaj.org/article/4d8ecc8a5bb8400cbafacb0914c0a426 |
op_doi |
https://doi.org/10.1590/S1678-91992005000100007 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
11 |
container_issue |
1 |
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1766337244697722880 |