Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response.
Background The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human...
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ftdoajarticles:oai:doaj.org/article:4d76b74a2aee4d979bdd97a87055a764 2023-05-15T15:15:36+02:00 Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. Michelle H F Dias Luiz F F Guimarães Matheus G Barcelos Eduardo U M Moreira Maria F A do Nascimento Taís N de Souza Camilla V Pires Talita A F Monteiro Jaap M Middeldorp Irene S Soares Cor J F Fontes Francis B Ntumngia John H Adams Flora S Kano Luzia H Carvalho 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010305 https://doaj.org/article/4d76b74a2aee4d979bdd97a87055a764 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010305 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010305 https://doaj.org/article/4d76b74a2aee4d979bdd97a87055a764 PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010305 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010305 2022-12-30T20:41:02Z Background The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human malaria parasites, the impact of EBV infection on the generation of human malaria immunity remains largely unexplored. Considering that this highly prevalent herpesvirus establishes a lifelong persistent infection on B-cells with possible influence on malaria immunity, we hypothesized that EBV co-infection could have impact on the naturally acquired antibody responses to P. vivax, the most widespread human malaria parasite. Methodology/principal findings The study design involved three cross-sectional surveys at six-month intervals (baseline, 6 and 12 months) among long-term P. vivax exposed individuals living in the Amazon rainforest. The approach focused on a group of malaria-exposed individuals whose EBV-DNA (amplification of balf-5 gene) was persistently detected in the peripheral blood (PersVDNA, n = 27), and an age-matched malaria-exposed group whose EBV-DNA could never be detected during the follow-up (NegVDNA, n = 29). During the follow-up period, the serological detection of EBV antibodies to lytic/ latent viral antigens showed that IgG antibodies to viral capsid antigen (VCA-p18) were significantly different between groups (PersVDNA > NegVDNA). A panel of blood-stage P. vivax antigens covering a wide range of immunogenicity confirmed that in general PersVDNA group showed low levels of antibodies as compared with NegVDNA. Interestingly, more significant differences were observed to a novel DBPII immunogen, named DEKnull-2, which has been associated with long-term neutralizing antibody response. Differences between groups were less pronounced with blood-stage antigens (such as MSP1-19) whose levels can fluctuate according to malaria transmission. Conclusions/significance In a proof-of-concept study we provide ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 8 e0010305 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Michelle H F Dias Luiz F F Guimarães Matheus G Barcelos Eduardo U M Moreira Maria F A do Nascimento Taís N de Souza Camilla V Pires Talita A F Monteiro Jaap M Middeldorp Irene S Soares Cor J F Fontes Francis B Ntumngia John H Adams Flora S Kano Luzia H Carvalho Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human malaria parasites, the impact of EBV infection on the generation of human malaria immunity remains largely unexplored. Considering that this highly prevalent herpesvirus establishes a lifelong persistent infection on B-cells with possible influence on malaria immunity, we hypothesized that EBV co-infection could have impact on the naturally acquired antibody responses to P. vivax, the most widespread human malaria parasite. Methodology/principal findings The study design involved three cross-sectional surveys at six-month intervals (baseline, 6 and 12 months) among long-term P. vivax exposed individuals living in the Amazon rainforest. The approach focused on a group of malaria-exposed individuals whose EBV-DNA (amplification of balf-5 gene) was persistently detected in the peripheral blood (PersVDNA, n = 27), and an age-matched malaria-exposed group whose EBV-DNA could never be detected during the follow-up (NegVDNA, n = 29). During the follow-up period, the serological detection of EBV antibodies to lytic/ latent viral antigens showed that IgG antibodies to viral capsid antigen (VCA-p18) were significantly different between groups (PersVDNA > NegVDNA). A panel of blood-stage P. vivax antigens covering a wide range of immunogenicity confirmed that in general PersVDNA group showed low levels of antibodies as compared with NegVDNA. Interestingly, more significant differences were observed to a novel DBPII immunogen, named DEKnull-2, which has been associated with long-term neutralizing antibody response. Differences between groups were less pronounced with blood-stage antigens (such as MSP1-19) whose levels can fluctuate according to malaria transmission. Conclusions/significance In a proof-of-concept study we provide ... |
format |
Article in Journal/Newspaper |
author |
Michelle H F Dias Luiz F F Guimarães Matheus G Barcelos Eduardo U M Moreira Maria F A do Nascimento Taís N de Souza Camilla V Pires Talita A F Monteiro Jaap M Middeldorp Irene S Soares Cor J F Fontes Francis B Ntumngia John H Adams Flora S Kano Luzia H Carvalho |
author_facet |
Michelle H F Dias Luiz F F Guimarães Matheus G Barcelos Eduardo U M Moreira Maria F A do Nascimento Taís N de Souza Camilla V Pires Talita A F Monteiro Jaap M Middeldorp Irene S Soares Cor J F Fontes Francis B Ntumngia John H Adams Flora S Kano Luzia H Carvalho |
author_sort |
Michelle H F Dias |
title |
Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. |
title_short |
Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. |
title_full |
Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. |
title_fullStr |
Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. |
title_full_unstemmed |
Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. |
title_sort |
impact of epstein-barr virus co-infection on natural acquired plasmodium vivax antibody response. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010305 https://doaj.org/article/4d76b74a2aee4d979bdd97a87055a764 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010305 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010305 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010305 https://doaj.org/article/4d76b74a2aee4d979bdd97a87055a764 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010305 |
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PLOS Neglected Tropical Diseases |
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16 |
container_issue |
8 |
container_start_page |
e0010305 |
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