Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina.
Background Dengue has propagated widely through the Americas. Most countries have not been able to maintain permanent larval mosquito control programs, and the long-term effects of control actions have rarely been documented. Methodology The study design was based on a before-and-after citywide asse...
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ftdoajarticles:oai:doaj.org/article:4d65293a854c49e29f2fec436f4d46c0 2023-05-15T15:14:33+02:00 Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. Ricardo E Gürtler Fernando M Garelli Héctor D Coto 2009-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000427 https://doaj.org/article/4d65293a854c49e29f2fec436f4d46c0 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19399168/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000427 https://doaj.org/article/4d65293a854c49e29f2fec436f4d46c0 PLoS Neglected Tropical Diseases, Vol 3, Iss 4, p e427 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000427 2022-12-31T07:09:42Z Background Dengue has propagated widely through the Americas. Most countries have not been able to maintain permanent larval mosquito control programs, and the long-term effects of control actions have rarely been documented. Methodology The study design was based on a before-and-after citywide assessment of Aedes aegypti larval indices and the reported incidence of dengue in Clorinda, northeastern Argentina, over 2003-2007. Interventions were mainly based on focal treatment with larvicides of every mosquito developmental site every four months (14 cycles), combined with limited source reduction efforts and ultra-low-volume insecticide spraying during emergency operations. The program conducted 120,000 house searches for mosquito developmental sites and 37,000 larvicide applications. Principal findings Random-effects regression models showed that Breteau indices declined significantly in nearly all focal cycles compared to pre-intervention indices clustered by neighborhood, after allowing for lagged effects of temperature and rainfall, baseline Breteau index, and surveillance coverage. Significant heterogeneity between neighborhoods was revealed. Larval indices seldom fell to 0 shortly after interventions at the same blocks. Large water-storage containers were the most abundant and likely to be infested. The reported incidence of dengue cases declined from 10.4 per 10,000 in 2000 (by DEN-1) to 0 from 2001 to 2006, and then rose to 4.5 cases per 10,000 in 2007 (by DEN-3). In neighboring Paraguay, the reported incidence of dengue in 2007 was 30.6 times higher than that in Clorinda. Conclusions Control interventions exerted significant impacts on larval indices but failed to keep them below target levels during every summer, achieved sustained community acceptance, most likely prevented new dengue outbreaks over 2003-2006, and limited to a large degree the 2007 outbreak. For further improvement, a shift is needed towards a multifaceted program with intensified coverage and source reduction efforts, lids or ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina PLoS Neglected Tropical Diseases 3 4 e427 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ricardo E Gürtler Fernando M Garelli Héctor D Coto Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Dengue has propagated widely through the Americas. Most countries have not been able to maintain permanent larval mosquito control programs, and the long-term effects of control actions have rarely been documented. Methodology The study design was based on a before-and-after citywide assessment of Aedes aegypti larval indices and the reported incidence of dengue in Clorinda, northeastern Argentina, over 2003-2007. Interventions were mainly based on focal treatment with larvicides of every mosquito developmental site every four months (14 cycles), combined with limited source reduction efforts and ultra-low-volume insecticide spraying during emergency operations. The program conducted 120,000 house searches for mosquito developmental sites and 37,000 larvicide applications. Principal findings Random-effects regression models showed that Breteau indices declined significantly in nearly all focal cycles compared to pre-intervention indices clustered by neighborhood, after allowing for lagged effects of temperature and rainfall, baseline Breteau index, and surveillance coverage. Significant heterogeneity between neighborhoods was revealed. Larval indices seldom fell to 0 shortly after interventions at the same blocks. Large water-storage containers were the most abundant and likely to be infested. The reported incidence of dengue cases declined from 10.4 per 10,000 in 2000 (by DEN-1) to 0 from 2001 to 2006, and then rose to 4.5 cases per 10,000 in 2007 (by DEN-3). In neighboring Paraguay, the reported incidence of dengue in 2007 was 30.6 times higher than that in Clorinda. Conclusions Control interventions exerted significant impacts on larval indices but failed to keep them below target levels during every summer, achieved sustained community acceptance, most likely prevented new dengue outbreaks over 2003-2006, and limited to a large degree the 2007 outbreak. For further improvement, a shift is needed towards a multifaceted program with intensified coverage and source reduction efforts, lids or ... |
format |
Article in Journal/Newspaper |
author |
Ricardo E Gürtler Fernando M Garelli Héctor D Coto |
author_facet |
Ricardo E Gürtler Fernando M Garelli Héctor D Coto |
author_sort |
Ricardo E Gürtler |
title |
Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. |
title_short |
Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. |
title_full |
Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. |
title_fullStr |
Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. |
title_full_unstemmed |
Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina. |
title_sort |
effects of a five-year citywide intervention program to control aedes aegypti and prevent dengue outbreaks in northern argentina. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000427 https://doaj.org/article/4d65293a854c49e29f2fec436f4d46c0 |
geographic |
Arctic Argentina |
geographic_facet |
Arctic Argentina |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 4, p e427 (2009) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19399168/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000427 https://doaj.org/article/4d65293a854c49e29f2fec436f4d46c0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000427 |
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PLoS Neglected Tropical Diseases |
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3 |
container_issue |
4 |
container_start_page |
e427 |
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1766344985607667712 |