An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants
Abstract Background Anopheles sinensis is an important vector for the spread of malaria in China. Olfactory-related behaviours, particularly oviposition site seeking, offer opportunities for disrupting the disease-transmission process. Results This is the first report of the identification and chara...
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ftdoajarticles:oai:doaj.org/article:4d12d5c714164c5eab71cff8673659fc 2023-05-15T15:05:14+02:00 An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants Hongmei Liu Luhong Liu Peng Cheng Xiaodan Huang Maoqing Gong 2018-10-01T00:00:00Z https://doi.org/10.1186/s12936-018-2501-4 https://doaj.org/article/4d12d5c714164c5eab71cff8673659fc EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2501-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2501-4 1475-2875 https://doaj.org/article/4d12d5c714164c5eab71cff8673659fc Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) Anopheles sinensis AsinOrco AsinOR10 3-Methylindole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2501-4 2022-12-31T10:24:04Z Abstract Background Anopheles sinensis is an important vector for the spread of malaria in China. Olfactory-related behaviours, particularly oviposition site seeking, offer opportunities for disrupting the disease-transmission process. Results This is the first report of the identification and characterization of AsinOrco and AsinOR10 in An. sinensis. AsinOrco and AsinOR10 share 97.49% and 90.37% amino acid sequence identity, respectively, with related sequences in Anopheles gambiae. A functional analysis demonstrated that AsinOrco- and AsinOR10-coexpressing HEK293 cells were highly sensitive to 3-methylindole, but showed no significant differences in response to other test odorants when compared to DMSO. Conclusions AsinOrco was characterized as a new member of the Orco ortholog subfamily. AsinOR10, which appears to be a member of the OR2-10 subfamily, is directly involved in identification of oviposition sites. This finding will help to elucidate the molecular mechanisms underlying olfactory signaling in An. sinensis and provide many more molecular targets for eco-friendly pest control. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Anopheles sinensis AsinOrco AsinOR10 3-Methylindole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Anopheles sinensis AsinOrco AsinOR10 3-Methylindole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hongmei Liu Luhong Liu Peng Cheng Xiaodan Huang Maoqing Gong An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants |
topic_facet |
Anopheles sinensis AsinOrco AsinOR10 3-Methylindole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Anopheles sinensis is an important vector for the spread of malaria in China. Olfactory-related behaviours, particularly oviposition site seeking, offer opportunities for disrupting the disease-transmission process. Results This is the first report of the identification and characterization of AsinOrco and AsinOR10 in An. sinensis. AsinOrco and AsinOR10 share 97.49% and 90.37% amino acid sequence identity, respectively, with related sequences in Anopheles gambiae. A functional analysis demonstrated that AsinOrco- and AsinOR10-coexpressing HEK293 cells were highly sensitive to 3-methylindole, but showed no significant differences in response to other test odorants when compared to DMSO. Conclusions AsinOrco was characterized as a new member of the Orco ortholog subfamily. AsinOR10, which appears to be a member of the OR2-10 subfamily, is directly involved in identification of oviposition sites. This finding will help to elucidate the molecular mechanisms underlying olfactory signaling in An. sinensis and provide many more molecular targets for eco-friendly pest control. |
format |
Article in Journal/Newspaper |
author |
Hongmei Liu Luhong Liu Peng Cheng Xiaodan Huang Maoqing Gong |
author_facet |
Hongmei Liu Luhong Liu Peng Cheng Xiaodan Huang Maoqing Gong |
author_sort |
Hongmei Liu |
title |
An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants |
title_short |
An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants |
title_full |
An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants |
title_fullStr |
An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants |
title_full_unstemmed |
An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants |
title_sort |
odorant receptor from anopheles sinensis in china is sensitive to oviposition attractants |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2501-4 https://doaj.org/article/4d12d5c714164c5eab71cff8673659fc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2501-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2501-4 1475-2875 https://doaj.org/article/4d12d5c714164c5eab71cff8673659fc |
op_doi |
https://doi.org/10.1186/s12936-018-2501-4 |
container_title |
Malaria Journal |
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17 |
container_issue |
1 |
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1766336978061623296 |