Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia
Objective: To investigate the relationship between polymorphisms of rs1532624 and rs289741 loci in cholesteryl ester transfer protein (CETP) genes and atherosclerotic cerebral infarction (ACI). Methods: The CETP gene rs1532624 and rs289741 in 95 patients with ACI and 177 healthy subjects were genoty...
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ftdoajarticles:oai:doaj.org/article:4cd5a8b209b8497e85d9dd602e0dc050 2023-05-15T15:04:21+02:00 Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia Lin Huang Dan-Xin Wang Li-Min Zhou Tao Wang Hai-Ying Zhang Yun-Xia Zhang Yin-Dong Zhang 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.231473 https://doaj.org/article/4cd5a8b209b8497e85d9dd602e0dc050 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=4;spage=309;epage=312;aulast=Huang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.231473 https://doaj.org/article/4cd5a8b209b8497e85d9dd602e0dc050 Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 4, Pp 309-312 (2018) cholesteryl ester transfer protein gene atherosclerotic cerebral infarction gene polymorphism Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.231473 2022-12-30T21:05:15Z Objective: To investigate the relationship between polymorphisms of rs1532624 and rs289741 loci in cholesteryl ester transfer protein (CETP) genes and atherosclerotic cerebral infarction (ACI). Methods: The CETP gene rs1532624 and rs289741 in 95 patients with ACI and 177 healthy subjects were genotyped by MassARRAY mass spectrometry. Each locus genotype and allele frequency distributions were compared. Results: The difference of allele frequency distribution between the rs1532624 (χ2=1.723, P =0.189) and rs289741 (χ2=2.466, P =0.116) were not statistically significant. The frequency distribution of rs1532624 genotype between the cerebral infarction group and healthy control group was statistically significant (χ2=7.096, P =0.029), while rs289741 genotype frequency distribution between the two groups was not statistically significant (χ=2.906, P =0.234). Conclusion: ACI have a positive correlation with rs1532624 polymorphism, and AA genotype may be susceptible factors of ACI. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 4 309 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cholesteryl ester transfer protein gene atherosclerotic cerebral infarction gene polymorphism Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
cholesteryl ester transfer protein gene atherosclerotic cerebral infarction gene polymorphism Arctic medicine. Tropical medicine RC955-962 Lin Huang Dan-Xin Wang Li-Min Zhou Tao Wang Hai-Ying Zhang Yun-Xia Zhang Yin-Dong Zhang Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
topic_facet |
cholesteryl ester transfer protein gene atherosclerotic cerebral infarction gene polymorphism Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To investigate the relationship between polymorphisms of rs1532624 and rs289741 loci in cholesteryl ester transfer protein (CETP) genes and atherosclerotic cerebral infarction (ACI). Methods: The CETP gene rs1532624 and rs289741 in 95 patients with ACI and 177 healthy subjects were genotyped by MassARRAY mass spectrometry. Each locus genotype and allele frequency distributions were compared. Results: The difference of allele frequency distribution between the rs1532624 (χ2=1.723, P =0.189) and rs289741 (χ2=2.466, P =0.116) were not statistically significant. The frequency distribution of rs1532624 genotype between the cerebral infarction group and healthy control group was statistically significant (χ2=7.096, P =0.029), while rs289741 genotype frequency distribution between the two groups was not statistically significant (χ=2.906, P =0.234). Conclusion: ACI have a positive correlation with rs1532624 polymorphism, and AA genotype may be susceptible factors of ACI. |
format |
Article in Journal/Newspaper |
author |
Lin Huang Dan-Xin Wang Li-Min Zhou Tao Wang Hai-Ying Zhang Yun-Xia Zhang Yin-Dong Zhang |
author_facet |
Lin Huang Dan-Xin Wang Li-Min Zhou Tao Wang Hai-Ying Zhang Yun-Xia Zhang Yin-Dong Zhang |
author_sort |
Lin Huang |
title |
Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
title_short |
Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
title_full |
Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
title_fullStr |
Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
title_full_unstemmed |
Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
title_sort |
tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.231473 https://doaj.org/article/4cd5a8b209b8497e85d9dd602e0dc050 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 4, Pp 309-312 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=4;spage=309;epage=312;aulast=Huang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.231473 https://doaj.org/article/4cd5a8b209b8497e85d9dd602e0dc050 |
op_doi |
https://doi.org/10.4103/1995-7645.231473 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
4 |
container_start_page |
309 |
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1766336130692677632 |