Genome-wide association testing in malaria studies in the presence of overdominance

• Published in: Malaria Journal
• Main Authors: Morine Akoth, John Odhiambo, Bernard Omolo
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2023
• Subjects: Allelic test; Case–control study; Genome-wide association; Malaria; MAX test; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Sickle
• Online Access: https://doi.org/10.1186/s12936-023-04533-2; https://doaj.org/article/4cbf58317c23400fa032cc75dc1b274e

Abstract Background In human genetics, heterozygote advantage (heterosis) has been detected in studies that focused on specific genes but not in genome-wide association studies (GWAS). For example, heterosis is believed to confer resistance to certain strains of malaria in patients heterozygous for...