Rickettsia felis identified in two fatal cases of acute meningoencephalitis.
Background Rickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly under...
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ftdoajarticles:oai:doaj.org/article:4b5bd57644fe4b3da09d41b717f2df94 2023-05-15T15:06:06+02:00 Rickettsia felis identified in two fatal cases of acute meningoencephalitis. Arthur H P Mawuntu Edison Johar Riane Anggraeni Feliana Feliana Janno B B Bernadus Dodi Safari Frilasita A Yudhaputri Rama Dhenni Yora P Dewi Cecilia Kato Ann M Powers Ronald Rosenberg Amin Soebandrio Khin S A Myint 2020-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007893 https://doaj.org/article/4b5bd57644fe4b3da09d41b717f2df94 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007893 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007893 https://doaj.org/article/4b5bd57644fe4b3da09d41b717f2df94 PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0007893 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007893 2022-12-31T13:55:47Z Background Rickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood. Methodology/principal findings We retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA. Conclusion/significance The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 2 e0007893 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Arthur H P Mawuntu Edison Johar Riane Anggraeni Feliana Feliana Janno B B Bernadus Dodi Safari Frilasita A Yudhaputri Rama Dhenni Yora P Dewi Cecilia Kato Ann M Powers Ronald Rosenberg Amin Soebandrio Khin S A Myint Rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Rickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood. Methodology/principal findings We retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA. Conclusion/significance The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases. |
format |
Article in Journal/Newspaper |
author |
Arthur H P Mawuntu Edison Johar Riane Anggraeni Feliana Feliana Janno B B Bernadus Dodi Safari Frilasita A Yudhaputri Rama Dhenni Yora P Dewi Cecilia Kato Ann M Powers Ronald Rosenberg Amin Soebandrio Khin S A Myint |
author_facet |
Arthur H P Mawuntu Edison Johar Riane Anggraeni Feliana Feliana Janno B B Bernadus Dodi Safari Frilasita A Yudhaputri Rama Dhenni Yora P Dewi Cecilia Kato Ann M Powers Ronald Rosenberg Amin Soebandrio Khin S A Myint |
author_sort |
Arthur H P Mawuntu |
title |
Rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
title_short |
Rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
title_full |
Rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
title_fullStr |
Rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
title_full_unstemmed |
Rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
title_sort |
rickettsia felis identified in two fatal cases of acute meningoencephalitis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0007893 https://doaj.org/article/4b5bd57644fe4b3da09d41b717f2df94 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0007893 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007893 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007893 https://doaj.org/article/4b5bd57644fe4b3da09d41b717f2df94 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007893 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
2 |
container_start_page |
e0007893 |
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1766337754045612032 |